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pro vyhledávání: '"Anne K. Merritt"'
Publikováno v:
Molecular and biochemical parasitology. 146(2)
0 d ondii is a widespread disease affecting primarily immunocomromised and pregnant individuals [1]. Atovaquone is a recently ntroduced anti-malarial compound with broad spectrum activty against various apicomplexan parasites [2–5] including T. ond
Autor:
Philip Hill, Kevin H. Ha, Anne K. Merritt, Brigitte Meunier, Jacques J. Kessl, Steven R. Meshnick, Bernard L. Trumpower, Benjamin B. Lange
Publikováno v:
The Journal of biological chemistry. 280(17)
Atovaquone is a new anti-malarial agent that specifically targets the cytochrome bc1 complex and inhibits parasite respiration. A growing number of failures of this drug in the treatment of malaria have been genetically linked to point mutations in t