Zobrazeno 1 - 10 of 38 pro vyhledávání: '"Anne Jokilammi"'
1
Akademický článek
An extracellular receptor tyrosine kinase motif orchestrating intracellular STAT activation
Autor: Katri Vaparanta, Anne Jokilammi, Mahlet Tamirat, Johannes A. M. Merilahti, Kari Salokas, Markku Varjosalo, Johanna Ivaska, Mark S. Johnson, Klaus Elenius
Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Specificity in signaling activated by receptor tyrosine kinases is typically attributed to characteristics of their intracellular domains. Here, the authors demonstrate that an extracellular receptor sequence motif controls intracellular signaling as
Externí odkaz: https://doaj.org/article/a1f72bfdc3b24f3ba724cff785319be7
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2
Akademický článek
Combined genetic and chemical screens indicate protective potential for EGFR inhibition to cardiomyocytes under hypoxia
Autor: Juho Heliste, Anne Jokilammi, Katri Vaparanta, Ilkka Paatero, Klaus Elenius
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract The return of blood flow to ischemic heart after myocardial infarction causes ischemia–reperfusion injury. There is a clinical need for novel therapeutic targets to treat myocardial ischemia–reperfusion injury. Here we screened for targe
Externí odkaz: https://doaj.org/article/b109947235e848e48d77e2e461549237
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3
Akademický článek
Receptor tyrosine kinase profiling of ischemic heart identifies ROR1 as a potential therapeutic target
Autor: Juho Heliste, Anne Jokilammi, Ilkka Paatero, Deepankar Chakroborty, Christoffer Stark, Timo Savunen, Maria Laaksonen, Klaus Elenius
Publikováno v: BMC Cardiovascular Disorders, Vol 18, Iss 1, Pp 1-12 (2018)
Abstract Background Receptor tyrosine kinases (RTK) are potential targets for the treatment of ischemic heart disease. The human RTK family consists of 55 members, most of which have not yet been characterized for expression or activity in the ischem
Externí odkaz: https://doaj.org/article/b98fc177bf2f4048905ea8749e1310a8
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9
STAT5b is a key effector of NRG-1/ERBB4-mediated cardiomyocyte growth
Autor: Katri Vaparanta, Anne Jokilammi, Ilkka Paatero, Johannes A. Merilahti, Juho Heliste, Karthik Amudhala Hemanthakumar, Riikka Kivelä, Kari Alitalo, Pekka Taimen, Klaus Elenius
The growth factor neuregulin-1 (NRG-1) regulates hypertrophic and hyperplastic myocardial growth and is currently under clinical investigation as a treatment for heart failure. We have previously demonstrated that an isoform of the NRG-1 receptor ERB
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f12e98cd02f75ab16b18d37c58c28d9
https://doi.org/10.1101/2022.10.05.510958
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10
Combined genetic and chemical screens indicate protective potential for EGFR inhibition to cardiomyocytes under hypoxia
Autor: Anne Jokilammi, Katri Vaparanta, Juho Heliste, Klaus Elenius, Ilkka Paatero
Publikováno v: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
The return of blood flow to ischemic heart after myocardial infarction causes ischemia–reperfusion injury. There is a clinical need for novel therapeutic targets to treat myocardial ischemia–reperfusion injury. Here we screened for targets for th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd078cca83e70e995088c962234e1372
https://pubmed.ncbi.nlm.nih.gov/34404849
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