Vaginal dysbiosis seems associated with hrHPV infection in women attending the Dutch Cervical Cancer Screening Program

Autor: Anne J. M. Loonen, Femke Verhagen, Ilse Luijten-de Vrije, Marjolein Lentjes-Beer, Cornelis J. Huijsmans, Adriaan J. C. van den Brule

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)

Human papillomavirus (HPV) is a sexually transmitted virus, which infects approximately 80% of all men and women at some time in their lives. Usually, the infection is resolved successfully by the body’s immune system. Persistent infection with hig

Externí odkaz: https://doaj.org/article/39deac7544334d9b801e52f1e65a4fd6

Glow-in-the-Dark Infectious Disease Diagnostics Using CRISPR-Cas9-Based Split Luciferase Complementation

Autor: Harmen J. van der Veer, Eva A. van Aalen, Claire M. S. Michielsen, Eva T. L. Hanckmann, Jeroen Deckers, Marcel M. G. J. van Borren, Jacky Flipse, Anne J. M. Loonen, Joost P. H. Schoeber, Maarten Merkx

Publikováno v: ACS Central Science, 9(4), 657-667. American Chemical Society

Nucleic acid detection methods based on CRISPR and isothermal amplification techniques show great potential for point-of-care diagnostic applications. However, most current methods rely on fluorescent or lateral flow assay readout, requiring external

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97ff6ed1cbe7036906f9c69b0edd1ebc
https://research.tue.nl/nl/publications/9f750d16-fe8c-467c-bd9d-446ab20d2b01

Comprehensive analytical and clinical evaluation of a RNA extraction-free saliva-based molecular assay for SARS-CoV-2

Autor: Joost P. H. Schoeber, Juliëtte M. Schlaghecke, Britt M. J. Meuwissen, Mara van Heertum, Adriaan J. C. van den Brule, Anne J. M. Loonen

Publikováno v: PLOS ONE. PLOS
PLOS ONE

Standard SARS-CoV-2 testing protocols using nasopharyngeal/throat (NP/T) swabs are invasive and require trained medical staff for reliable sampling. In addition, it has been shown that PCR is more sensitive as compared to antigen-based tests. Here we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b8c729756e1275769d05429e1c9692d
https://doi.org/10.1371/journal.pone.0268082

Biomarkers and molecular analysis to improve bloodstream infection diagnostics in an emergency care unit.

Autor: Anne J M Loonen, Cornelis P C de Jager, Janna Tosserams, Ron Kusters, Mirrian Hilbink, Peter C Wever, Adriaan J C van den Brule

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e87315 (2014)

Molecular pathogen detection from blood is still expensive and the exact clinical value remains to be determined. The use of biomarkers may assist in preselecting patients for immediate molecular testing besides blood culture. In this study, 140 pati

Externí odkaz: https://doaj.org/article/3c1c0699173941998a1b276c30544e28

The utility of peripheral blood leucocyte ratios as biomarkers in infectious diseases:a systematic review and meta-analysis

Autor: Philipp Schuetz, Hugo J. Gale, Anne J. M. Loonen, Clark D Russell, Naomi S. Bulteel, Arun Parajuli, Georgios Merekoulias, J Kenneth Baillie, Cornelis P.C. de Jager

Publikováno v: Russell, C D, Parajuli, A, Gale, H J, Bulteel, N S, Schuetz, P, de Jager, C P C, Loonen, A J M, Merekoulias, G I & Baillie, J 2019, ' The utility of peripheral blood leucocyte ratios as biomarkers in infectious diseases : a systematic review and meta-analysis ', Journal of Infection . https://doi.org/10.1016/j.jinf.2019.02.006

OBJECTIVES: To assess the utility of the neutrophil:lymphocyte (NLR), lymphocyte:monocyte (LMR) and platelet:lymphocyte ratios (PLR) as infection biomarkers.METHODS: PubMed/MEDLINE, Embase and Cochrane databases were searched to identify eligible art

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70ec66dbe8c3365ff0650b71dda20b97
https://hdl.handle.net/20.500.11820/cc44f036-fdf4-49c7-a372-ad7d8f39b972