Biomarkers and molecular analysis to improve bloodstream infection diagnostics in an emergency care unit.

Autor: Anne J M Loonen, Cornelis P C de Jager, Janna Tosserams, Ron Kusters, Mirrian Hilbink, Peter C Wever, Adriaan J C van den Brule

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e87315 (2014)

Molecular pathogen detection from blood is still expensive and the exact clinical value remains to be determined. The use of biomarkers may assist in preselecting patients for immediate molecular testing besides blood culture. In this study, 140 pati

Externí odkaz: https://doaj.org/article/3c1c0699173941998a1b276c30544e28

Vaginal dysbiosis seems associated with hrHPV infection in women attending the Dutch Cervical Cancer Screening Program

Autor: Anne J. M. Loonen, Femke Verhagen, Ilse Luijten-de Vrije, Marjolein Lentjes-Beer, Cornelis J. Huijsmans, Adriaan J. C. van den Brule

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)

Human papillomavirus (HPV) is a sexually transmitted virus, which infects approximately 80% of all men and women at some time in their lives. Usually, the infection is resolved successfully by the body’s immune system. Persistent infection with hig

Externí odkaz: https://doaj.org/article/39deac7544334d9b801e52f1e65a4fd6

Fast bioluminescent nucleic acid detection using one-pot isothermal amplification and dCas9-based split luciferase complementation

Autor: Harmen J. van der Veer, Eva A. van Aalen, Claire M. S. Michielsen, Eva T. L. Hanckmann, Jeroen Deckers, Marcel M. G. J. van Borren, Jacky Flipse, Anne J. M. Loonen, Joost P. H. Schoeber, Maarten Merkx

Nucleic acid detection methods based on isothermal amplification techniques show great potential for point-of-care diagnostic applications. However, most current methods rely on fluorescent or lateral flow assay readout, requiring external excitation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0fbd9190530a07ca4aa640c3c939ed9c
https://doi.org/10.1101/2022.09.12.507659

The utility of peripheral blood leucocyte ratios as biomarkers in infectious diseases:a systematic review and meta-analysis

Autor: Philipp Schuetz, Hugo J. Gale, Anne J. M. Loonen, Clark D Russell, Naomi S. Bulteel, Arun Parajuli, Georgios Merekoulias, J Kenneth Baillie, Cornelis P.C. de Jager

Publikováno v: Russell, C D, Parajuli, A, Gale, H J, Bulteel, N S, Schuetz, P, de Jager, C P C, Loonen, A J M, Merekoulias, G I & Baillie, J 2019, ' The utility of peripheral blood leucocyte ratios as biomarkers in infectious diseases : a systematic review and meta-analysis ', Journal of Infection . https://doi.org/10.1016/j.jinf.2019.02.006

OBJECTIVES: To assess the utility of the neutrophil:lymphocyte (NLR), lymphocyte:monocyte (LMR) and platelet:lymphocyte ratios (PLR) as infection biomarkers.METHODS: PubMed/MEDLINE, Embase and Cochrane databases were searched to identify eligible art

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70ec66dbe8c3365ff0650b71dda20b97
https://hdl.handle.net/20.500.11820/cc44f036-fdf4-49c7-a372-ad7d8f39b972

Conditional Pten knock-out mice: a model for metastatic phaeochromocytoma

Autor: Angelique C.J. Ziel-van der Made, Anne J M Loonen, Ronald R. de Krijger, Francien H van Nederveen, Suzanne Corvers, Winand N.M. Dinjens, Esther Korpershoek, Jan Trapman, Xiaoqian Ma, Hanneke Korsten, Jos Jonkers

Publikováno v: Journal of Pathology, 217(4), 597-604. John Wiley & Sons Ltd.

Phaeochromocytomas (PCCs) are neuro-endocrine tumours of the adrenal medulla that are usually benign, but approximately 10% of patients develop metastases. Malignant PCCs can only be diagnosed with certainty if metastases are present. Here we describ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7cb139ad997b19352427bb9843d745b
https://pure.eur.nl/en/publications/80687719-9a59-4d61-aa98-09c14f2d0be1