Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Anne Jämsä"'
Autor:
Marco Heestermans, Clément Naudin, Reiner K. Mailer, Sandra Konrath, Kristin Klaetschke, Anne Jämsä, Maike Frye, Carsten Deppermann, Giordano Pula, Piotr Kuta, Manuel A. Friese, Mathias Gelderblom, Albert Sickmann, Roger J. S. Preston, Jerzy-Roch Nofer, Stefan Rose-John, Lynn M. Butler, Ophira Salomon, Evi X. Stavrou, Thomas Renné
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Blood coagulation is started by contact to surfaces and this is the principle for a commonly used diagnostic clotting test, aPTT. Here, the authors identify the structure in coagulation factor XII that initiates surface-driven coagulation and use the
Externí odkaz:
https://doaj.org/article/23842f92b8124cd4863e0db2254038e6
Autor:
Lynn M. Butler, Roger J. S. Preston, Mathias Gelderblom, Evi X. Stavrou, Sandra Konrath, Thomas Renné, Stefan Rose-John, Carsten Deppermann, Giordano Pula, Clément Naudin, Anne Jämsä, Piotr Kuta, Marco Heestermans, Kristin Klaetschke, Albert Sickmann, Jerzy-Roch Nofer, Manuel A. Friese, Reiner K. Mailer, Ophira Salomon, Maike Frye
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Contact activation refers to the process of surface-induced activation of factor XII (FXII), which initiates blood coagulation and is captured by the activated partial thromboplastin time (aPTT) assay. Here, we show the mechanism and diagnostic impli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c140e35cb0d93ee1c6b189fe22da7a
https://doaj.org/article/23842f92b8124cd4863e0db2254038e6
https://doaj.org/article/23842f92b8124cd4863e0db2254038e6
Autor:
Con Panousis, Anne Jämsä, Ingo Pragst, Patricia Hedenqvist, Marion Fries, Jenny Björkqvist, Matthew P. Hardy, Michael J. Wilson, Michael Broomé, Andrew D. Nash, Marc W. Nolte, Magnus Larsson, Katrin F. Nickel, Stefan Schmidbauer, Thomas Renné, Gerhard Dickneite, Veronika Rayzman
Publikováno v:
Science Translational Medicine. 6
Currently used anticoagulants prevent thrombosis but increase bleeding. We show an anticoagulation therapy without bleeding risk based on a plasma protease factor XII function-neutralizing antibody. We screened for antibodies against activated factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d8bacd6b0303b54061e3ab81a4b472
https://doi.org/10.1126/scitranslmed.3006804
https://doi.org/10.1126/scitranslmed.3006804
Autor:
Antonio Di Gennaro, Ulrich Hassiepen, Katrin F. Nickel, Tobias A. Fuchs, Olga Luengo, Andy T. Long, Evi X. Stavrou, Thomas Renné, Thorsten Krieger, Ellinor Kenne, Hartmut Schlüter, Keith R. McCrae, Stefanie Flohr, Riccardo Senter, Mar Guilarte, Moisés Labrador, Jenny Björkqvist, Lynn M. Butler, Anne Jämsä, Frederic Cumin, Anna Sala-Cunill, Victoria Cardona, Linda Labberton, Parvin Kumar, Coen Maas
Publikováno v:
Journal of Allergy and Clinical Immunology, 135(4), 1031. Mosby Inc.
BASE-Bielefeld Academic Search Engine
Europe PubMed Central
BASE-Bielefeld Academic Search Engine
Europe PubMed Central
Background Anaphylaxis is an acute, potentially lethal, multisystem syndrome resulting from the sudden release of mast cell–derived mediators into the circulation. Objectives and Methods We report here that a plasma protease cascade, the factor XII
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::127db8bc1237ca5bc8815fe2139c5e55
https://pubmed.ncbi.nlm.nih.gov/25240785
https://pubmed.ncbi.nlm.nih.gov/25240785
Autor:
Christer Sylvén, Viktor Drvota, Pontus Blomberg, Nondita Sarkar, Khalid B. Islam, Anne Jämsä, Eva Wärdell
Publikováno v:
Journal of Thrombosis and Thrombolysis. 12:151-156
Therapeutic myocardial angiogenesis by means of transient overexpression of angiogenic growth factors is a potential treatment modality for severe ischemic heart disease. This study was undertaken in the rat to examine effects of phVEGF-A165 myocardi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54a2affd0e381eeff76de110f4abf9e2
https://doi.org/10.1023/a:1012971421128
https://doi.org/10.1023/a:1012971421128
Publikováno v:
Thrombosis and haemostasis. 110(3)
SummaryPlasma prekallikrein is the liver-derived precursor of the trypsin-like serine protease plasma kallikrein (PK) and circulates in plasma bound to high molecular weight kininogen. The zymogen is converted to PK by activated factor XII. PK drives
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0d12a53972ee2220e68e97d7dfb9b66
https://pubmed.ncbi.nlm.nih.gov/23846131
https://pubmed.ncbi.nlm.nih.gov/23846131
Publikováno v:
Journal of Biomedical Science
Journal of Biomedical Science, Vol 18, Iss 1, p 76 (2011)
Journal of Biomedical Science, Vol 18, Iss 1, p 76 (2011)
Background Accumulation of amyloid β-peptide (Aβ) in the plaques is one of the major pathological features in Alzheimer's disease (AD). Sequential cleavage of amyloid precursor protein (APP) by β-site APP cleaving enzyme 1 (BACE-1) and γ-secretas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b962b3d5dfc20fd3002a5d86460934
https://pubmed.ncbi.nlm.nih.gov/22018341
https://pubmed.ncbi.nlm.nih.gov/22018341
Autor:
Gösta Hiller, Jan Ottervald, Gang Liu, Ann-Cathrin Radesäter, Mervi Vasänge, Karin Agerman, Anne Jämsä, Jonas Malmström
Publikováno v:
Journal of Biomedical Science
Journal of Biomedical Science, Vol 16, Iss 1, p 55 (2009)
Journal of Biomedical Science, Vol 16, Iss 1, p 55 (2009)
Background Deregulated activation of cyclin-dependent kinase-5 (Cdk5) is implicated in neurodegenerative disorders such as Alzheimer's disease. One of the restricting factors for developing specific Cdk5 inhibitors is the lack of reproducible and wel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e50a3f6daa3e9a255d9b34f974fa00aa
https://pubmed.ncbi.nlm.nih.gov/19534817
https://pubmed.ncbi.nlm.nih.gov/19534817
Publikováno v:
Neuroreport. 17(9)
The hallmarks of Alzheimer's disease include extracellular plaques primarily consisting of amyloid-beta peptide and intracellular neurofibrillary tangles composed of highly phosphorylated tau protein. We report that exposure of organotypic hippocampa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10925f2418a1f2e56da4cdcac931640b
https://pubmed.ncbi.nlm.nih.gov/16738486
https://pubmed.ncbi.nlm.nih.gov/16738486
Glutamate treatment and p25 transfection increase Cdk5 mediated tau phosphorylation in SH-SY5Y cells
Autor:
Nodi Dehvari, Anders Bäckström, Elin Gustafsson, Richard F. Cowburn, Gösta Hiller, Anne Jämsä, Mervi Vasänge
Publikováno v:
Biochemical and biophysical research communications. 345(1)
Neurofibrillary tangles (NFT) of hyperphosphorylated tau protein are a major pathological hallmark of Alzheimer’s disease (AD). One of the tau phosphorylating kinases with pathological relevance in AD has been suggested to be the cyclin-dependent k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daa50fda37fcdaa3c1cf2a74b7b7cc4c
https://pubmed.ncbi.nlm.nih.gov/16678793
https://pubmed.ncbi.nlm.nih.gov/16678793