Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Anne Houdusse"'
Autor:
Daniel Auguin, Julien Robert-Paganin, Stéphane Réty, Carlos Kikuti, Amandine David, Gabriele Theumer, Arndt W. Schmidt, Hans-Joachim Knölker, Anne Houdusse
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Inherited cardiomyopathies are common cardiac diseases worldwide, leading in the late stage to heart failure and death. The most promising treatments against these diseases are small molecules directly modulating the force produced by β-car
Externí odkaz:
https://doaj.org/article/363d3a02b7d54aa8bbcb3c56b4a01f3f
Autor:
Mingyue Sun, Olena Pylypenko, Zhe Zhou, Mingqian Xu, Qinghong Li, Anne Houdusse, Sven C.D. van IJzendoorn
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 6, Pp 983-1005 (2024)
Microvillus inclusion disease (MVID) is a rare condition that is present from birth and affects the digestive system. People with MVID experience severe diarrhea that is difficult to control, cannot absorb dietary nutrients, and struggle to grow and
Externí odkaz:
https://doaj.org/article/c65a3f8bf8c842dabe04a6095fe2e333
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 4, p e1012005 (2024)
Myosin motors use the energy of ATP to produce force and directed movement on actin by a swing of the lever-arm. ATP is hydrolysed during the off-actin re-priming transition termed recovery stroke. To provide an understanding of chemo-mechanical tran
Externí odkaz:
https://doaj.org/article/47400e179e0f4109ad671695026e751c
Autor:
Louise Canon, Carlos Kikuti, Vicente J. Planelles-Herrero, Tianming Lin, Franck Mayeux, Helena Sirkia, Young il Lee, Leila Heidsieck, Léonid Velikovsky, Amandine David, Xiaoyan Liu, Dihia Moussaoui, Emma Forest, Peter Höök, Karl J. Petersen, Tomos E. Morgan, Aurélie Di Cicco, Julia Sirés-Campos, Emmanuel Derivery, Daniel Lévy, Cédric Delevoye, H. Lee Sweeney, Anne Houdusse
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Myosin VI (Myo6) is the only minus-end directed nanomotor on actin, allowing it to uniquely contribute to numerous cellular functions. As for other nanomotors, the proper functioning of Myo6 relies on precise spatiotemporal control of motor
Externí odkaz:
https://doaj.org/article/9c1a197ee24d4bfc8261601e8244d9ad
Autor:
Dihia Moussaoui, James P. Robblee, Julien Robert-Paganin, Daniel Auguin, Fabio Fisher, Patricia M. Fagnant, Jill E. Macfarlane, Julia Schaletzky, Eddie Wehri, Christoph Mueller-Dieckmann, Jake Baum, Kathleen M. Trybus, Anne Houdusse
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Malaria results in more than 500,000 deaths per year and the causative Plasmodium parasites continue to develop resistance to all known agents, including different antimalarial combinations. The class XIV myosin motor PfMyoA is part of a cor
Externí odkaz:
https://doaj.org/article/649b74fa0af0445585a6975102ee7c70
Autor:
Alessandro Grinzato, Daniel Auguin, Carlos Kikuti, Neha Nandwani, Dihia Moussaoui, Divya Pathak, Eaazhisai Kandiah, Kathleen M. Ruppel, James A. Spudich, Anne Houdusse, Julien Robert-Paganin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract To save energy and precisely regulate cardiac contractility, cardiac muscle myosin heads are sequestered in an ‘off’ state that can be converted to an ‘on’ state when exertion is increased. The ‘off’ state is equated with a folde
Externí odkaz:
https://doaj.org/article/0c05293899494749a2e39fe8e07c3200
Autor:
Fanomezana Moutse Ranaivoson, Vincent Crozet, Matthieu P. M. H. Benoit, Amna Abdalla Mohammed Khalid, Carlos Kikuti, Helena Sirkia, Ahmed El Marjou, Stéphanie Miserey-Lenkei, Ana B. Asenjo, Hernando Sosa, Christoph F. Schmidt, Steven S. Rosenfeld, Anne Houdusse
Publikováno v:
Open Biology, Vol 13, Iss 9 (2023)
KIF20A is a critical kinesin for cell division and a promising anti-cancer drug target. The mechanisms underlying its cellular roles remain elusive. Interestingly, unusual coupling between the nucleotide- and microtubule-binding sites of this kinesin
Externí odkaz:
https://doaj.org/article/d507f9c467904d2fad8c1e25083b89b1
Autor:
Julien Robert-Paganin, Xiao-Ping Xu, Mark F. Swift, Daniel Auguin, James P. Robblee, Hailong Lu, Patricia M. Fagnant, Elena B. Krementsova, Kathleen M. Trybus, Anne Houdusse, Niels Volkmann, Dorit Hanein
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Plasmodium falciparum moves by an atypical process called gliding motility which comprises of atypical myosin A (PfMyoA) and filaments of the dynamic and divergent PfActin-1 (PfAct1). Here authors present the cryo-EM structure of PfMyoA bound to fila
Externí odkaz:
https://doaj.org/article/1e9f084757d3479aa82cffe48fcd9158
Publikováno v:
eLife, Vol 10 (2021)
The molecular motor myosin undergoes a series of major structural transitions during its force-producing motor cycle. The underlying mechanism and its coupling to ATP hydrolysis and actin binding are only partially understood, mostly due to sparse st
Externí odkaz:
https://doaj.org/article/7a02ba89d5714ea9b1e6fe77d851f4db
Autor:
Lara Katharina Krüger, Matthieu Gélin, Liang Ji, Carlos Kikuti, Anne Houdusse, Manuel Théry, Laurent Blanchoin, Phong T Tran
Publikováno v:
eLife, Vol 10 (2021)
Mitotic spindle function depends on the precise regulation of microtubule dynamics and microtubule sliding. Throughout mitosis, both processes have to be orchestrated to establish and maintain spindle stability. We show that during anaphase B spindle
Externí odkaz:
https://doaj.org/article/5e8cfa0e216d4ab2b63cacf0a66832a1