Benzalkonium Chloride-Preserved Anti-Glaucomatous Eye Drops and Their Effect on Human Conjunctival Goblet Cells in vitro

Autor: Anne Hedengran, Xenia Begun, Olivia Müllertz, Zaynab Mouhammad, Rupali Vohra, Jeffrey Bair, Darlene A. Dartt, Barbara Cvenkel, Steffen Heegaard, Goran Petrovski, Miriam Kolko

Publikováno v: Biomedicine Hub, Vol 6, Iss 2, Pp 69-76 (2021)

Introduction: Most intraocular pressure (IOP)-lowering eye drops are preserved with benzalkonium chloride (BAK). This can increase side effects and decrease adherence. Particularly, damage to the mucin-producing conjunctival goblet cells may be an is

Externí odkaz: https://doaj.org/article/19a5c41ecea94a248fb02d450673908d

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Adverse effects and Safety in Glaucoma Patients - Agreement on Clinical Trial Outcomes for Reports on Eye Drops (ASGARD) - A Delphi Consensus Statement

Autor: Anna-Sophie Thein, Anne Hedengran, Augusto Azuara-Blanco, Reiko Arita, Barbara Cvenkel, Gus Gazzard, Steffen Heegaard, Cintia S. de Paiva, Goran Petrovski, Verena Prokosch-Willing, Tor P. Utheim, Gianni Virgili, Miriam Kolko

Publikováno v: Thein, A-S, Hedengran, A, Azuara-Blanco, A, Arita, R, Cvenkel, B, Gazzard, G, Heegaard, S, de Paiva, C S, Petrovski, G, Prokosch-Willing, V, Utheim, T P, Virgili, G & Kolko, M 2022, ' Adverse effects and Safety in Glaucoma Patients-Agreement on Clinical Trial Outcomes for Reports on Eye Drops (ASGARD)-A Delphi Consensus Statement ', American journal of ophthalmology, vol. 241, pp. 190-197 . https://doi.org/10.1016/j.ajo.2022.05.007
Thein, A S, Hedengran, A, Azuara-Blanco, A, Arita, R, Cvenkel, B, Gazzard, G, Heegaard, S, de Paiva, C S, Petrovski, G, Prokosch-Willing, V, Utheim, T P, Virgili, G & Kolko, M 2022, ' Adverse Effects and Safety in Glaucoma Patients : Agreement on Clinical Trial Outcomes for Reports on Eye Drops (ASGARD)—A Delphi Consensus Statement ', American Journal of Ophthalmology, vol. 241, pp. 190-197 . https://doi.org/10.1016/j.ajo.2022.05.007

Purpose: The purpose of this study is to establish consensus among experts on outcomes and methods to be used in clinical trials to assess adverse effects of anti-glaucomatous eye drops. Design: Modified Delphi method. Methods: Clinical experts from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad0b6882b047fa955979ef7e4c86685f
https://pure.qub.ac.uk/en/publications/ac7601d7-f6e3-43bf-b642-33dcf4330d72

Generic benzalkonium chloride-preserved travoprost eye drops are not identical to the branded polyquarternium-1-preserved travoprost eye drop: Effect on cultured human conjunctival goblet cells and their physicochemical properties

Autor: Anne Hedengran, Josefine Clement Freiberg, Pernille May Hansen, Jette Jacobsen, Susan Weng Larsen, Stine Harloff‐Helleberg, Kristine Freude, Gerard Boix‐Lemonche, Goran Petrovski, Steffen Heegaard, Miriam Kolko

Publikováno v: Hedengran, A, Freiberg, J C, Hansen, P M, Jacobsen, J, Larsen, S W, Harloff-helleberg, S, Freude, K, Boix-lemonche, G, Petrovski, G, Heegaard, S & Kolko, M 2022, ' Generic benzalkonium chloride-preserved travoprost eye drops are not identical to the branded polyquarternium-1-preserved travoprost eye drop : Effect on cultured human conjunctival goblet cells and their physicochemical properties ', Acta Ophthalmologica, vol. 100, no. 7, pp. 819-827 . https://doi.org/10.1111/aos.15163

PurposeTo investigate the effect of polyquaternium-1 (PQ)-preserved and benzalkonium chloride (BAK)-preserved travoprost eye drops on viability of primary human conjunctival goblet cell (GC) cultures and on secretion of mucin and cytokines. Furthermo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db0a4c27f499aa3ab7df49f36de52e4d
https://pubmed.ncbi.nlm.nih.gov/35527390

ASGARD – Adverse events and safety in glaucoma patients: assessing reports on eye drops

Autor: Anna‐Sophie Thein, Anne Hedengran, Reiko Arita, Barbara Cvenkel, Gus Gazzard, Steffen Heegaard, Cintia De Paiva, Goran Petrovski, Verena Prokosch‐Willing, Tor P. Utheim, Gianni Virgili, Augusto Azuara‐Blanco, Miriam Kolko

Publikováno v: Acta Ophthalmologica. 100

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce9f5ce1823ba663bd586156d478fcf9
https://doi.org/10.1111/j.1755-3768.2022.103