Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Anne Heald"'
Autor:
Andrew C. Kitchener, Ashley C. Banyard, Anna Meredith, Michael McDonald, Georg Hantke, Caroline Millins, Kari-Anne Heald, Katherine A. Sainsbury
Publikováno v:
MAMMALIAN BIOLOGY
The European polecat (Mustela putorius) almost became extinct in Britain in the early twentieth century, but populations are now recovering. As seen in other endangered carnivore populations, disease is one potential threat to recovery. This study as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::918a2da2a348fa9952a2d2168771cd1f
https://doi.org/10.1007/s42991-020-00046-6
https://doi.org/10.1007/s42991-020-00046-6
Autor:
Jamil I. Bacha, George McAllister, Heather A. Skynner, Tim Bonnert, Paul C. Guest, Kamran Salim, Julie Kerby, Hector Urien-Rodriguez, Margaret S. Beer, Anne Heald, Tim R. Fenton, Emma Watts
Publikováno v:
Journal of Biological Chemistry. 277:15482-15485
Recent studies have shown that G-protein-coupled receptors (GPCRs) can assemble as high molecular weight homo- and hetero-oligomeric complexes. This can result in altered receptor-ligand binding, signaling, or intracellular trafficking. We have co-tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::745eed80c5d9cc20d61cdeb70a7a087f
https://doi.org/10.1074/jbc.m201539200
https://doi.org/10.1074/jbc.m201539200
Autor:
Alan P. Watt, Angus Murray Macleod, Russell J. Mortishire-Smith, Margaret S. Beer, Peter W. Hunt, Desmond O'Connor, Castro Jl, Laure Hitzel, Monique Bodil Van Niel, Anne Heald, David C. Evans, Susan K. F. Cheng
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:3243-3248
A solution phase synthesis for the preparation of 3-aryloxy-2-propanolamine libraries has been developed. This resulted in the identification of 5 as a ligand with dual affinity for 5-HT 1 A and serotonin re-uptake receptors which shows excellent pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05755bfadad1a9e7c1fe97455c47d029
https://doi.org/10.1016/s0960-894x(99)00570-3
https://doi.org/10.1016/s0960-894x(99)00570-3
Autor:
Ian Collins, M. B. Van Niel, Michael G. N. Russell, Michael Rowley, Karen L Locker, Desmond O'Connor, Denise Morrison, Susan Koon-Fung Cheng, Christopher Moyes, Josephine A. Stanton, Hugh M. Verrier, Simon Charles Goodacre, Anne Heald, Bindi Sohal, Andrew Pike, Angus Murray Macleod, Howard B. Broughton, Steve Thomas, Margaret S. Beer, Castro Jl, A. P. Watt
Publikováno v:
Journal of Medicinal Chemistry. 42:2087-2104
It has previously been reported that a 3-(3-(piperazin-1-yl)propyl)indole series of 5-HT1D receptor ligands have pharmacokinetic advantages over the corresponding 3-(3-(piperidin-1-yl)propyl)indole series and that the reduced pKa of the piperazines c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a1f087a3d8ab5ce7a9aa3e51393c3b5
https://doi.org/10.1021/jm981133m
https://doi.org/10.1021/jm981133m
Autor:
Austin John Reeve, Josephine A. Stanton, Margaret S. Beer, Anne Heald, Leslie J. Street, Bindi Sohal, A. P. Watt, Alexander Richard Guiblin, Victor G. Matassa, Francine Sternfeld, Richard Alexander Jelley, Peter Alan Hunt
Publikováno v:
Journal of Medicinal Chemistry. 42:677-690
The design, synthesis, and biological evaluation of a novel series of 3-[2-(pyrrolidin-1-yl)ethyl]indoles with excellent selectivity for h5-HT1D (formerly 5-HT1Dalpha) receptors over h5-HT1B (formerly 5-HT1Dbeta) receptors are described. Clinically e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66e5620fadeaf03fbf2a02b13529de5b
https://doi.org/10.1021/jm9805687
https://doi.org/10.1021/jm9805687
Publikováno v:
European Journal of Pharmacology. 264:213-216
This study, carried out in pig caudate membranes, characterises the radioligand binding site labelled with [ 3 H]L-694,247 (2-[5-[3-(4-methylsulphonylamino)benzyl-1,2,4-oxadiazol-5-yl]-1 H -indole-3-yl]ethylamine). The affinities of 27 standard compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a9171e8b8ad5297069171debe4c4e80
https://doi.org/10.1016/0014-2999(94)00527-3
https://doi.org/10.1016/0014-2999(94)00527-3
Autor:
Margaret S. Beer, Josephine A. Stanton, Michael G. N. Russell, Anne Heald, Howard B. Broughton, Kate Scholey, José L. Castro, Victor G. Matassa
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:1207-1212
The syntheses of the benzofuran ( 1 ) and dihydrobenzofuran ( 10 ) analogues of 5-carboxamidotryptamine ( 5-CT ) were accomplished utilising a Horner-Emmons reaction on a benzofuranone. Compound 1 was a relatively potent 5-HT 1D agonist, although les
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15e6a549b86e20ebf0a3415a638c7688
https://doi.org/10.1016/s0960-894x(01)80331-0
https://doi.org/10.1016/s0960-894x(01)80331-0
Publikováno v:
Annals of the New York Academy of Sciences. 713
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72fc0adc0d573efabe76a3f1af289163
https://pubmed.ncbi.nlm.nih.gov/8185188
https://pubmed.ncbi.nlm.nih.gov/8185188
Publikováno v:
European journal of pharmacology. 253(3)
In the present study we have described an ex vivo binding assay in mice to measure the central nervous system (CNS) activity of systemically administered CCKB receptor antagonists. This assay incorporated a transcardiac perfusion step to remove the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c5d1abdde09e76d5a31ea66bed8fcca
https://pubmed.ncbi.nlm.nih.gov/8200418
https://pubmed.ncbi.nlm.nih.gov/8200418