Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Anne Hautala"'
Publikováno v:
Clinical therapeutics. 38(4)
Purpose: The cost-effectiveness of first-line chronic lymphocytic leukemia treatments was assessed among patients unsuitable for full doses of fludarabine. Methods: The study's key outcome was the life-time incremental cost-effectiveness ratio (ICER)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b4eda98d83f90d9fd3097a511068f00
https://pubmed.ncbi.nlm.nih.gov/26970696
https://pubmed.ncbi.nlm.nih.gov/26970696
Autor:
Jaana Kantola, Kaj Räty, Juha Hakala, Tero Kunnari, Sirke Torkkell, Kristiina Ylihonko, Anne Hautala, Pekka Mäntsälä
Publikováno v:
The Journal of Antibiotics. 56:143-153
This paper focuses on study of second and third ring cyclization in anthracycline biosynthesis by a heterologous gene expression. Firstly, anthracycline non-producing Streptomyces peucetius mutant, D2 was heterologously complemented to produce daunom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d30aaaf0b1b4b63c3184093c2a31a4ae
https://doi.org/10.7164/antibiotics.56.143
https://doi.org/10.7164/antibiotics.56.143
Autor:
Jaana Kantola, Kaj Räty, Pekka Mäntsälä, Kristiina Ylihonko, Juha Hakala, Anne Hautala, Sirke Torkkell
Publikováno v:
Microbiology. 148:3375-3384
In this study a set of Streptomyces galilaeus ATCC 31615 mutants was characterized, which are incapable of synthesizing some or all of the deoxyhexose sugars of aclacinomycin A. Complementation experiments with the the mutant strains H026, H038, H039
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a572d97a595a765ee6e865ea3673ad58
https://doi.org/10.1099/00221287-148-11-3375
https://doi.org/10.1099/00221287-148-11-3375
Publikováno v:
Gene. 293:115-122
We have cloned and sequenced polyketide synthase (PKS) genes from the aclacinomycin producer Streptomyces galilaeus ATCC 31,615. The sequenced 13.5-kb region contained 13 complete genes. Their organization as well as their protein sequences showed hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f73f5b590bcbe59835c90e743a6db9ef
https://doi.org/10.1016/s0378-1119(02)00699-6
https://doi.org/10.1016/s0378-1119(02)00699-6
Publikováno v:
Microbiology. 146:155-163
The anthracycline skeleton is biosynthesized by aromatic (type II) polyketide synthases. Furthermore, three post-polyketide steps are needed to form the basic aglycone of anthracyclines. Auramycinone was produced in Streptomyces lividans by introduci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9652e20f370edaca1951b5197c2f8b71
https://doi.org/10.1099/00221287-146-1-155
https://doi.org/10.1099/00221287-146-1-155
Autor:
Jaana, Kantola, Tero, Kunnari, Anne, Hautala, Juha, Hakala, Kristiina, Ylihonko, Pekka, Mäntsälä
Publikováno v:
Microbiology (Reading, England). 146
The anthracycline skeleton is biosynthesized by aromatic (type II) polyketide synthases. Furthermore, three post-polyketide steps are needed to form the basic aglycone of anthracyclines. Auramycinone was produced in Streptomyces lividans by introduci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0ba8c2b3f0aeb9cc174e07b28c0b037a
https://pubmed.ncbi.nlm.nih.gov/10658662
https://pubmed.ncbi.nlm.nih.gov/10658662
Autor:
Juha Hakala, Kristiina Ylihonko, Pekka Mäntsälä, Mikko Metsä-Ketelä, Laura Halo, Anne Hautala, Virpi Salo
Publikováno v:
FEMS microbiology letters. 180(1)
Degenerated oligonucleotide primers were designed to amplify fragments of ketosynthase genes from polyketide antibiotics producing Streptomyces spp. and bacterial strains enriched from soil samples. Cell lysates were used as templates in amplificatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66f963ee4e3722cccb17b6927cf679ce
https://pubmed.ncbi.nlm.nih.gov/10547437
https://pubmed.ncbi.nlm.nih.gov/10547437
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(18)
Compounds produced by the polyketide ketoreductase deficient Streptomyces mutants HO61 and P67 are described. The structures of the compounds indicate that ketoreductase activity is required for correct condensation of the polyketide chain in the bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::029372d74bd3628b8b0579749bfa5857
https://pubmed.ncbi.nlm.nih.gov/10509907
https://pubmed.ncbi.nlm.nih.gov/10509907
Autor:
Carmen Méndez, Juha Hakala, Jaana Kantola, Gloria Blanco, Kristiina Ylihonko, Tero Kunnari, Pekka Mäntsälä, Anne Hautala, José A. Salas
Publikováno v:
Scopus-Elsevier
Background: Mithramycin, nogalamycin and aclacinomycins are aromatic polyketide antibiotics that exhibit antitumour activity. The precursors of these antibiotics are formed via a polyketide biosynthetic pathway in which acetate (for mithramycinone an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e0043b8388593cd5093d4ee6cecf9e4
https://pubmed.ncbi.nlm.nih.gov/9375253
https://pubmed.ncbi.nlm.nih.gov/9375253
Publikováno v:
The Journal of antibiotics. 50(6)
Streptomyces steffisburgensis (NRRL 3193, ATCC 27466) is described as a steffimycin producer. Steffimycin belongs to the anthracycline group of aromatic polyketide antibiotics. The structural analysis of the products accumulated by the wild type ATCC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df2e54631a4229605e339b7ba1ad1a88
https://pubmed.ncbi.nlm.nih.gov/9268006
https://pubmed.ncbi.nlm.nih.gov/9268006