A Combined 1 H/6 Li NMR DOSY Strategy Finally Uncovers the Structure of Isopropyllithium in THF

Autor: Hassan Oulyadi, Ghanem Hamdoun, Catherine Fressigné, Anne Harrison-Marchand, Jacques Maddaluno, Gabriella Barozzino-Consiglio

Publikováno v: Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2017, 23 (51), pp.12475-12479. ⟨10.1002/chem.201702990⟩

International audience; Despite its common use in synthesis, the structure of isopropylliyhium in THF has never been determined, a dimer being generally proposed but not supported. This paper fills this data gap through a sophisticated NMR study that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b641c0363a5b97e1b44b283deb425a3
https://doi.org/10.1002/chem.201702990

Chiral Lithium Amido Aryl Zincates: Simple and Efficient Chemo- and Enantio-Selective Aryl Transfer Reagents

Autor: Amel Ben Abdeladhim, Gabriella Barozzino-Consiglio, Pauline Chaumont-Olive, Mathieu Rouen, Anne Harrison-Marchand, Jacques Maddaluno

Publikováno v: Angewandte Chemie International Edition
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2019, 58 (10), pp.3193-3197. ⟨10.1002/anie.201813510⟩

International audience; An enantioselective aryl transfer is promoted using chiral tricoordinated lithium amido aryl zincates that are easily accessible reagents and whose chiral appendage is simply recovered for reuse. The arylation reaction is run

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad06b66b207535cce7de0ad48356b264
https://pubmed.ncbi.nlm.nih.gov/30653791

Access to Anti or Syn 2-Amino-1,3-diol Scaffolds from a Common Decarboxylative Aldol Adduct

Autor: Jacques Rouden, Anne Harrison-Marchand, Jacques Maddaluno, Pauline Chaumont, Jérôme Baudoux

Publikováno v: Journal of Organic Chemistry
Journal of Organic Chemistry, American Chemical Society, 2018, 83 (15), pp.8081-8091. ⟨10.1021/acs.joc.8b00901⟩

International audience; A straightforward synthetic pathway allowing the access to anti or syn 2-amino-1,3-diol scaffolds is presented. The strategy relies on a diastereoselective organocatalyzed decarboxylative aldol reaction of a N-Boc-hemimalonate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61fe1a4a76ee4646a7fe3ed71d5b15ed
https://pubmed.ncbi.nlm.nih.gov/29953234

Alkyllithium Mixed Aggregates: Dynamic Behavior and Comprehensive Analysis of NMR 2J7Li–7Li Spin–Spin Coupling

Autor: Laurent Joubert, Hassan Oulyadi, Jacques Maddaluno, Vincent Tognetti, Muriel Sebban, Anne Harrison-Marchand, Ghanem Hamdoun

Publikováno v: Organometallics
Organometallics, American Chemical Society, 2015, 34 (10), pp.1932-1941. ⟨10.1021/acs.organomet.5b00162⟩

International audience; The measurement and assignment of scalar couplings in NMR spectra have, of course, been of interest to chemists for a long time because of the useful structural and dynamic information that can be provided. In the case of orga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::852b18598a5afd6d711ecf797e67d9f6
https://doi.org/10.1021/acs.organomet.5b00162

Chiral Lithium Amides: Tuning Asymmetric Synthesis on the Basis of Structural Parameters

Autor: Anne Harrison-Marchand, Jacques Maddaluno, Gabriella Barozzino-Consiglio

Publikováno v: Chemical Record
Chemical Record, Chemical Society of Japan, 2017, 17 (6), pp.622-639. ⟨10.1002/tcr.201600115⟩

International audience; An overview on the structural arrangements adopted by Chiral Lithium Amides (CLAs), alone or in mixed complexes, is presented. These species are important reagents for asymmetric synthesis and understanding their organization

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10cb317e69963395fe87480cf99f14a7
https://hal.archives-ouvertes.fr/hal-02019166