Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Anne Haberkorn"'
Autor:
Huai-Xiang Hao, Morvarid Mohseni, Giordano Caponigro, Peter S. Hammerman, Jeffrey A. Engelman, Susan E. Moody, Saskia M. Brachmann, Eusebio Manchado, Eric Billy, Anne Haberkorn, Malika Kazic-Legueux, Lukas Manuel Dunkl, Hongyun Wang, Roberto Velazquez, Chen Liu, Hengyu Lu
Schematic illustration of MEKi-induced MAPK pathway feedback activation, SHP099 dose-dependent reduction of p-MEK induction by MEKi, and MEKi-induced p-AKT levels.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab33e010e3ab7eccd5822273f9c9b791
https://doi.org/10.1158/1535-7163.22506412
https://doi.org/10.1158/1535-7163.22506412
Autor:
Huai-Xiang Hao, Morvarid Mohseni, Giordano Caponigro, Peter S. Hammerman, Jeffrey A. Engelman, Susan E. Moody, Saskia M. Brachmann, Eusebio Manchado, Eric Billy, Anne Haberkorn, Malika Kazic-Legueux, Lukas Manuel Dunkl, Hongyun Wang, Roberto Velazquez, Chen Liu, Hengyu Lu
Evaluation of the in vitro synergy in anti-proliferation and the MAPK pathway suppression of MEK and SHP2, PI3K, or RTK inhibitors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::660e4d6468aaa320a2141ef18295a229
https://doi.org/10.1158/1535-7163.22506403
https://doi.org/10.1158/1535-7163.22506403
Autor:
Huai-Xiang Hao, Morvarid Mohseni, Giordano Caponigro, Peter S. Hammerman, Jeffrey A. Engelman, Susan E. Moody, Saskia M. Brachmann, Eusebio Manchado, Eric Billy, Anne Haberkorn, Malika Kazic-Legueux, Lukas Manuel Dunkl, Hongyun Wang, Roberto Velazquez, Chen Liu, Hengyu Lu
FGFR1 was recently shown to be activated as part of a compensatory response to prolonged treatment with the MEK inhibitor trametinib in several KRAS-mutant lung and pancreatic cancer cell lines. We hypothesize that other receptor tyrosine kinases (RT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb37e86fd9fce1d8e8b84e82f0895deb
https://doi.org/10.1158/1535-7163.c.6538387.v1
https://doi.org/10.1158/1535-7163.c.6538387.v1
Autor:
Huai-Xiang Hao, Morvarid Mohseni, Giordano Caponigro, Peter S. Hammerman, Jeffrey A. Engelman, Susan E. Moody, Saskia M. Brachmann, Eusebio Manchado, Eric Billy, Anne Haberkorn, Malika Kazic-Legueux, Lukas Manuel Dunkl, Hongyun Wang, Roberto Velazquez, Chen Liu, Hengyu Lu
mRNA levels (TPM, transcripts per million reads in RNAseq) of SHP2, RTKs, and their ligands in all cell lines tested.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb76ba04ff665a541405d5ba87ccb38
https://doi.org/10.1158/1535-7163.22506388
https://doi.org/10.1158/1535-7163.22506388
Autor:
Huai-Xiang Hao, Morvarid Mohseni, Giordano Caponigro, Peter S. Hammerman, Jeffrey A. Engelman, Susan E. Moody, Saskia M. Brachmann, Eusebio Manchado, Eric Billy, Anne Haberkorn, Malika Kazic-Legueux, Lukas Manuel Dunkl, Hongyun Wang, Roberto Velazquez, Chen Liu, Hengyu Lu
Quantification of p-MEK and tubulin levels and percentages of p-MEK reduction in the MEKi combination group normalized to tubulin in all cell lines tested.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a55407540f6d444bd5511f15ded794b
https://doi.org/10.1158/1535-7163.22506391.v1
https://doi.org/10.1158/1535-7163.22506391.v1
Autor:
Huai-Xiang Hao, Morvarid Mohseni, Giordano Caponigro, Peter S. Hammerman, Jeffrey A. Engelman, Susan E. Moody, Saskia M. Brachmann, Eusebio Manchado, Eric Billy, Anne Haberkorn, Malika Kazic-Legueux, Lukas Manuel Dunkl, Hongyun Wang, Roberto Velazquez, Chen Liu, Hengyu Lu
Validation of HRAS/NRAS double knock-out clones and the contribution of mutant KRAS to the feedback activation in NCI-H358 and MIA PaCa-2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c27a004abd1fec7a8b122158ae53362f
https://doi.org/10.1158/1535-7163.22506409.v1
https://doi.org/10.1158/1535-7163.22506409.v1
Autor:
Huai-Xiang Hao, Morvarid Mohseni, Giordano Caponigro, Peter S. Hammerman, Jeffrey A. Engelman, Susan E. Moody, Saskia M. Brachmann, Eusebio Manchado, Eric Billy, Anne Haberkorn, Malika Kazic-Legueux, Lukas Manuel Dunkl, Hongyun Wang, Roberto Velazquez, Chen Liu, Hengyu Lu
A list of KRAS mutant cell lines in the study with lineages, zygosity determined by RNAseq, and percentages of p-MEK reduction by 5 micromolar SHP099 in the MEKi combination group.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77b50f9d879ab7ef9d2b327ff110c4ac
https://doi.org/10.1158/1535-7163.22506394
https://doi.org/10.1158/1535-7163.22506394
Autor:
Huai-Xiang Hao, Morvarid Mohseni, Giordano Caponigro, Peter S. Hammerman, Jeffrey A. Engelman, Susan E. Moody, Saskia M. Brachmann, Eusebio Manchado, Eric Billy, Anne Haberkorn, Malika Kazic-Legueux, Lukas Manuel Dunkl, Hongyun Wang, Roberto Velazquez, Chen Liu, Hengyu Lu
Changes in phospho-SHP2 levels following MEKi treatment in studied KRAS mutant lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08eb335f1334c84b5ede5f57cf58305c
https://doi.org/10.1158/1535-7163.22506397.v1
https://doi.org/10.1158/1535-7163.22506397.v1
Autor:
Huai-Xiang Hao, Morvarid Mohseni, Giordano Caponigro, Peter S. Hammerman, Jeffrey A. Engelman, Susan E. Moody, Saskia M. Brachmann, Eusebio Manchado, Eric Billy, Anne Haberkorn, Malika Kazic-Legueux, Lukas Manuel Dunkl, Hongyun Wang, Roberto Velazquez, Chen Liu, Hengyu Lu
Evaluation of the in vivo combination benefit and the MAPK pathway suppression of MEK and SHP2 inhibitors in MIA PaCa-2 xenograft and a colon cancer PDX model.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28b11cd871cf995cfbefd65b8284f9df
https://doi.org/10.1158/1535-7163.22506400.v1
https://doi.org/10.1158/1535-7163.22506400.v1
Autor:
Dominik Pistorius, Kathrin Buntin, Eric Weber, Etienne Richard, Caroline Bouquet, Séverine Wollbrett, Hugo Regenass, Victor Peón, Marcel Böhm, Régis Kessler, Thomas Gempeler, Anne Haberkorn, Laurin Wimmer, Christian Lanshoeft, John Davis, Dominik Hainzl, Joseph Anthony D'Alessio, Eusebio Manchado, Frank Petersen
Publikováno v:
Chemistry – A European Journal. 28
Access to the cyclic depsipeptide FR900359 (FR), a selective G