Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Anne Grapin-Botton"'
Autor:
Keiichi Katsumoto, Siham Yennek, Chunguang Chen, Luis Fernando Delgadillo Silva, Sofia Traikov, Dror Sever, Ajuna Azad, Jingdong Shan, Seppo Vainio, Nikolay Ninov, Stephan Speier, Anne Grapin-Botton
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Diabetes is characterized by loss or dysfunction of pancreatic β-cells. Here the authors show that the signalling protein WNT4 is heterogeneously activated by β-cells during their postnatal maturation with WNT4 positive cells being more mature, and
Externí odkaz:
https://doaj.org/article/4a0ca094e5a94a2bbe4ee3371e323f93
Autor:
Carla A. Gonçalves, Michael Larsen, Sascha Jung, Johannes Stratmann, Akiko Nakamura, Marit Leuschner, Lena Hersemann, Rashmiparvathi Keshara, Signe Perlman, Lene Lundvall, Lea Langhoff Thuesen, Kristine Juul Hare, Ido Amit, Anne Jørgensen, Yung Hae Kim, Antonio del Sol, Anne Grapin-Botton
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
From single-cell transcriptome analyses to defining culture media for spheroids, the authors provide a census of information to understand the development of human pancreatic progenitors. This approach identifies signalling pathways (EGF and FGF) reg
Externí odkaz:
https://doaj.org/article/4dd4448416d0483cbbb89a084390dda1
Autor:
Mads Borries, Younes Farhangi Barooji, Siham Yennek, Anne Grapin-Botton, Kirstine Berg-Sørensen, Lene B. Oddershede
Publikováno v:
Frontiers in Physics, Vol 8 (2020)
The biophysical properties of polymer based gels, for instance the commonly used Matrigel, crucially depend on polymer concentration. Only certain polymer concentrations will produce a gel optimal for a specific purpose, for instance for organoid dev
Externí odkaz:
https://doaj.org/article/0cda9a5121d94514a5b1dfaad9c2eb27
Autor:
Lydie Flasse, Siham Yennek, Cédric Cortijo, Irene Seijo Barandiaran, Marine R.-C. Kraus, Anne Grapin-Botton
Publikováno v:
Cell Reports, Vol 31, Iss 8, Pp - (2020)
Summary: Cell polarity is essential for the architecture and function of numerous epithelial tissues. Here, we show that apical restriction of planar cell polarity (PCP) components is necessary for the maintenance of epithelial integrity. Using the m
Externí odkaz:
https://doaj.org/article/c13ce84ab00d46ee9bb4872205b3d93c
Autor:
Violeta Georgieva Tsonkova, Fredrik Wolfhagen Sand, Xenia Asbæk Wolf, Lars Groth Grunnet, Anna Kirstine Ringgaard, Camilla Ingvorsen, Louise Winkel, Mark Kalisz, Kevin Dalgaard, Christine Bruun, Johannes Josef Fels, Charlotte Helgstrand, Sven Hastrup, Fredrik Kryh Öberg, Erik Vernet, Michael Paolo Bastner Sandrini, Allan Christian Shaw, Carsten Jessen, Mads Grønborg, Jacob Hald, Hanni Willenbrock, Dennis Madsen, Rasmus Wernersson, Lena Hansson, Jan Nygaard Jensen, Annette Plesner, Tomas Alanentalo, Maja Borup Kjær Petersen, Anne Grapin-Botton, Christian Honoré, Jonas Ahnfelt-Rønne, Jacob Hecksher-Sørensen, Philippe Ravassard, Ole D. Madsen, Claude Rescan, Thomas Frogne
Publikováno v:
Molecular Metabolism, Vol 8, Iss , Pp 144-157 (2018)
Objective: To characterize the EndoC-βH1 cell line as a model for human beta cells and evaluate its beta cell functionality, focusing on insulin secretion, proliferation, apoptosis and ER stress, with the objective to assess its potential as a scree
Externí odkaz:
https://doaj.org/article/87dc16429b2843beab1b7a3a86b28d77
Autor:
Maja Borup Kjær Petersen, Ajuna Azad, Camilla Ingvorsen, Katja Hess, Mattias Hansson, Anne Grapin-Botton, Christian Honoré
Publikováno v:
Stem Cell Reports, Vol 9, Iss 4, Pp 1246-1261 (2017)
The production of insulin-producing β cells from human embryonic stem cells (hESCs) in vitro represents a promising strategy for a cell-based therapy for type 1 diabetes mellitus. To explore the cellular heterogeneity and temporal progression of end
Externí odkaz:
https://doaj.org/article/ea2f1e8739d4437ca9cbb7b7e47b2db2
Autor:
Hjalte List Larsen, Laura Martín-Coll, Alexander Valentin Nielsen, Christopher V. E. Wright, Ala Trusina, Yung Hae Kim, Anne Grapin-Botton
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
The pancreas arises from a small population of cells but how individual cells contribute to organ formation is unclear. Here, the authors deconstruct pancreas organogenesis into clonal units, showing that single progenitors give rise to heterogeneous
Externí odkaz:
https://doaj.org/article/5617ac1576cd4daf93bca36ae542b223
Autor:
Svend Bertel Dahl-Jensen, Siham Yennek, Lydie Flasse, Hjalte List Larsen, Dror Sever, Gopal Karremore, Ivana Novak, Kim Sneppen, Anne Grapin-Botton
Publikováno v:
PLoS Biology, Vol 16, Iss 7, p e2002842 (2018)
The mammalian pancreas is a branched organ that does not exhibit stereotypic branching patterns, similarly to most other glands. Inside branches, it contains a network of ducts that undergo a transition from unconnected microlumen to a mesh of interc
Externí odkaz:
https://doaj.org/article/f991fcaf992d4c06a7866c73ce22ac95
Publikováno v:
Cell Reports, Vol 2, Iss 6, Pp 1593-1606 (2012)
Planar cell polarity (PCP) refers to the collective orientation of cells within the epithelial plane. We show that progenitor cells forming the ducts of the embryonic pancreas express PCP proteins and exhibit an active PCP pathway. Planar polarity pr
Externí odkaz:
https://doaj.org/article/816818efe59f42849cda4b811d00abae
Autor:
Palle Serup, Carsten Gustavsen, Tino Klein, Leah A. Potter, Robert Lin, Nandita Mullapudi, Ewa Wandzioch, Angela Hines, Ashley Davis, Christine Bruun, Nina Engberg, Dorthe R. Petersen, Janny M. L. Peterslund, Raymond J. MacDonald, Anne Grapin-Botton, Mark A. Magnuson, Kenneth S. Zaret
Publikováno v:
Disease Models & Mechanisms, Vol 5, Iss 6, Pp 956-966 (2012)
SUMMARY Extracellular signals in development, physiology, homeostasis and disease often act by regulating transcription. Herein we describe a general method and specific resources for determining where and when such signaling occurs in live animals a
Externí odkaz:
https://doaj.org/article/63f5b0186d674ef187de317844c569e5