Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Anne Grahl"'
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Signal transmission and regulation of G-protein-coupled receptors (GPCRs) by ligands occurs via modulation of complex conformational equilibria. Here authors quantify these equilibria and their dynamics in the β1-adrenergic receptor in its apo form
Externí odkaz:
https://doaj.org/article/8bb35a77f6744d2dbe67f65cb91afeaf
Autor:
Layara Akemi Abiko, Raphael Dias Teixeira, Sylvain Engilberge, Anne Grahl, Tobias Mühlethaler, Timothy Sharpe, Stephan Grzesiek
Recent high-pressure NMR results indicate that the preactive conformation of the β 1 -adrenergic receptor (β 1 AR) harbours completely empty cavities of ~100 Å 3 volume, which disappear in the active conformation of the receptor. Here we have loca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a64f5fec5a3eef7248a5a0c3898a111c
https://edoc.unibas.ch/90103/
https://edoc.unibas.ch/90103/
Proteins often contain cavities, which are usually assumed to be water-filled. Recent high-pressure NMR results indicate that the preactive conformation of the β1-adrenergic receptor (β1AR) contains completely empty cavities (dry voids) of about
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd56aac1efeff289b104658a6294e2af
https://doi.org/10.1101/2021.08.30.457941
https://doi.org/10.1101/2021.08.30.457941
Autor:
Layara Akemi, Abiko, Raphael, Dias Teixeira, Sylvain, Engilberge, Anne, Grahl, Tobias, Mühlethaler, Timothy, Sharpe, Stephan, Grzesiek
Publikováno v:
Nature chemistry. 14(10)
Recent high-pressure NMR results indicate that the preactive conformation of the β
Publikováno v:
Journal of the American Chemical Society. 141:16663-16670
G protein-coupled receptors (GPCRs) are versatile chemical sensors, which transmit the signal of an extracellular binding event across the plasma membrane to the intracellular side. This function is achieved via the modulation of highly dynamical equ
Autor:
Nikolaus Dietz, Kenneth N. Goldie, Ching-Ju Tsai, Stephan Grzesiek, Ramon Guixà-González, Oliver Hartley, Polina Isaikina, Xavier Deupi, Henning Stahlberg, Gebhard F. X. Schertler, Anne Grahl, Timm Maier, Filip Pamula
The human CC chemokine receptor 5 (CCR5) is a G protein-coupled receptor (GPCR) that plays a major role in inflammation and is involved in the pathology of cancer, HIV, and COVID-19. Despite its significance as a drug target, the activation mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::843ed9171efef0fb6518cb4af265eaa9
https://doi.org/10.1101/2020.11.27.401117
https://doi.org/10.1101/2020.11.27.401117
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2127
NMR spectroscopy is a method of choice to characterize structure, function, and dynamics of integral membrane proteins at atomic resolution. Here, we describe protocols for sample preparation and characterization by NMR spectroscopy of two integral m
Publikováno v:
Methods in Molecular Biology ISBN: 9781071603727
NMR spectroscopy is a method of choice to characterize structure, function, and dynamics of integral membrane proteins at atomic resolution. Here, we describe protocols for sample preparation and characterization by NMR spectroscopy of two integral m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33adf329b07969100ed456e7846ed5f9
https://doi.org/10.1007/978-1-0716-0373-4_24
https://doi.org/10.1007/978-1-0716-0373-4_24
Autor:
Alvar D. Gossert, Shin Isogai, Leonildo Delgado, Anne Grahl, Christian Opitz, Stephan Grzesiek, Bastian Franke
Publikováno v:
Journal of Biomolecular NMR. 71:173-184
Baculovirus-infected insect cells have become a powerful tool to express recombinant proteins for structural and functional studies by NMR spectroscopy. This article provides an introduction into the insect cell/baculovirus expression system and its
Publikováno v:
Journal of the American Chemical Society. 141(42)
G protein-coupled receptors (GPCRs) are versatile chemical sensors, which transmit the signal of an extracellular binding event across the plasma membrane to the intracellular side. This function is achieved via the modulation of highly dynamical equ