Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Anne Gigout"'
Autor:
Anne Gigout, Donata Harazin, Louise M. Topping, Didier Merciris, Sven Lindemann, Christian Brenneis, Ahuva Nissim
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-11 (2021)
Abstract Background Osteoarthritis (OA) is a disease of the whole joint, with articular cartilage breakdown as a major characteristic. Inflammatory mediators, proteases, and oxidants produced by chondrocytes are known to be responsible for driving ca
Externí odkaz:
https://doaj.org/article/e5482f8d14654940b82769ea2ce6dc76
Autor:
Ditte Reker, Cecilie F. Kjelgaard-Petersen, Anne Sofie Siebuhr, Martin Michaelis, Anne Gigout, Morten A. Karsdal, Christoph Ladel, Anne C. Bay-Jensen
Publikováno v:
Journal of Translational Medicine, Vol 15, Iss 1, Pp 1-12 (2017)
Abstract Background Sprifermin (recombinant human fibroblast growth factor 18) is in clinical development as a potential disease-modifying osteoarthritis drug (DMOAD). In vitro studies have shown that cartilage regenerative properties of sprifermin i
Externí odkaz:
https://doaj.org/article/0395c88151af4cf6841e97940a9f6699
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 2, p 531 (2020)
The environment surrounding chondrocytes changes drastically in osteoarthritis (OA). For instance, the osmolarity in cartilage (ranging from 350 to 460 mOsm in healthy tissue) decreases during the progression of OA, reaching 270 mOsm. The objective o
Externí odkaz:
https://doaj.org/article/ddc47284c8ce4c20a272281c25422037
Autor:
Anne Gigout, Daniela Werkmann, Stephanie Menges, Christian Brenneis, Frances Henson, Kyra J. Cowan, Djordje Musil, Christian S. Thudium, Hans Gühring, Martin Michaelis, Kerstin Kleinschmidt‐Doerr
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.)REFERENCES.
To preclinically characterize a mutant form of growth and differentiation factor 5, R399E, with reduced osteogenic properties as a potential disease-modifying osteoarthritis (OA) drug.Cartilage, synovium, and meniscus samples from patients with OA we
Publikováno v:
Journal of Cellular and Molecular Medicine
The growth and differentiation factor 5 (GDF‐5) is known to play a key role in cartilage morphogenesis and homeostasis, and a single‐nucleotide polymorphism in its promoter sequence was found to be associated with osteoarthritis (OA). In addition
Autor:
Julie DeMartino, Jeff Kraines, Hugues Dolgos, Kerstin Kleinschmidt-Dörr, Robert Townsend, Anne Gigout, Flavie Moreau, Kyra J. Cowan
Publikováno v:
Drug Discovery Today. 25:1054-1064
Osteoarthritis (OA) is a common disease worldwide with large unmet medical needs. To bring innovative treatments to OA patients, we at Merck have implemented a comprehensive strategy for drug candidate evaluation. We have a clear framework for decisi
Publikováno v:
BioResearch Open Access
For cartilage repair in vivo or evaluation of new therapeutic approaches in vitro, the generation of functional cartilage tissue is of crucial importance and can only be achieved if the phenotype of the chondrocytes is preserved. Three-dimensional (3
Autor:
Christian Brenneis, Donata Harazin, Didier Merciris, Anne Gigout, Sven Lindemann, Ahuva Nissim, Louise M. Topping
Publikováno v:
Arthritis Research & Therapy
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-11 (2021)
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-11 (2021)
Background Osteoarthritis (OA) is a disease of the whole joint, with articular cartilage breakdown as a major characteristic. Inflammatory mediators, proteases, and oxidants produced by chondrocytes are known to be responsible for driving cartilage d
Autor:
Thorbjørn Gantzel, D. Reker, Anne Sofie Siebuhr, Anders Aspberg, Anne-Christine Bay-Jensen, Morten A. Karsdal, Christoph Ladel, Anne Gigout, Christian S. Thudium, M. Michaelis, M. W. Berchtold
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Reker, D, Siebuhr, A S, Thudium, C S, Gantzel, T, Ladel, C, Michaelis, M, Aspberg, A, Berchtold, M W, Karsdal, M A, Gigout, A & Bay-Jensen, A C 2020, ' Sprifermin (rhFGF18) versus vehicle induces a biphasic process of extracellular matrix remodeling in human knee OA articular cartilage ex vivo ', Scientific Reports, vol. 10, 6011 . https://doi.org/10.1038/s41598-020-63216-z
Scientific Reports
Reker, D, Siebuhr, A S, Thudium, C S, Gantzel, T, Ladel, C, Michaelis, M, Aspberg, A, Berchtold, M W, Karsdal, M A, Gigout, A & Bay-Jensen, A C 2020, ' Sprifermin (rhFGF18) versus vehicle induces a biphasic process of extracellular matrix remodeling in human knee OA articular cartilage ex vivo ', Scientific Reports, vol. 10, 6011 . https://doi.org/10.1038/s41598-020-63216-z
Scientific Reports
Sprifermin, recombinant human fibroblast growth factor 18 (rhFGF18), induces cartilage regeneration in knees of patients with osteoarthritis (OA). We hypothesized that a temporal multiphasic process of extracellular matrix (ECM) degradation and forma
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 2, p 531 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 2
International Journal of Molecular Sciences
Volume 21
Issue 2
The environment surrounding chondrocytes changes drastically in osteoarthritis (OA). For instance, the osmolarity in cartilage (ranging from 350 to 460 mOsm in healthy tissue) decreases during the progression of OA, reaching 270 mOsm. The objective o