Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Anne Gatignol"'
Publikováno v:
Retrovirology, Vol 21, Iss 1, Pp 1-20 (2024)
Abstract Human immunodeficiency virus (HIV) and human T cell leukemia virus (HTLV) have replicative and latent stages of infection. The status of the viruses is dependent on the cells that harbour them and on different events that change the transcri
Externí odkaz:
https://doaj.org/article/18956beaf97b4d17ad061a534a53541a
Autor:
Ryan P. Goguen, Olivier Del Corpo, Camille M.G. Malard, Aïcha Daher, Sergio P. Alpuche-Lazcano, Michelle J. Chen, Robert J. Scarborough, Anne Gatignol
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 23, Iss , Pp 1020-1034 (2021)
The expression of short hairpin RNAs (shRNAs) in cells has many potential therapeutic applications, including as a functional cure for HIV. The RNA polymerase III promoters H1, 7SK, and U6 have all been used to express shRNAs. However, there have bee
Externí odkaz:
https://doaj.org/article/5c5eb089f6c0434f859658bd9d510f3c
Autor:
Olivier Del Corpo, Ryan P. Goguen, Camille M.G. Malard, Aïcha Daher, Susan Colby-Germinario, Robert J. Scarborough, Anne Gatignol
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 18, Iss , Pp 815-830 (2019)
U1 interference (U1i) RNAs can be designed to correct splicing defects and target pathogenic RNA, such as HIV-1 RNA. In this study, we show that U1i RNAs that enhance HIV-1 RNA splicing are more effective at inhibiting HIV-1 production compared to to
Externí odkaz:
https://doaj.org/article/206069a0580241bc868024ce2fed03c8
Autor:
Sergio P Alpuche-Lazcano, James Saliba, Vivian V Costa, Gabriel H Campolina-Silva, Fernanda M Marim, Lucas S Ribeiro, Volker Blank, Andrew J Mouland, Mauro M Teixeira, Anne Gatignol
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 5, p e0009425 (2021)
Zika virus (ZIKV) infection of neurons leads to neurological complications and congenital malformations of the brain of neonates. To date, ZIKV mechanism of infection and pathogenesis is not entirely understood and different studies on gene regulatio
Externí odkaz:
https://doaj.org/article/435c988ad546417cb6504fb2c5fd46d2
Publikováno v:
Retrovirology, Vol 14, Iss 1, Pp 1-14 (2017)
Externí odkaz:
https://doaj.org/article/f217e09fbe1b410fbc1c9fc16ada5a02
Autor:
Robert J. Scarborough, Anne Gatignol
Publikováno v:
Viruses, Vol 10, Iss 1, p 8 (2017)
HIV-1 drug therapies can prevent disease progression but cannot eliminate HIV-1 viruses from an infected individual. While there is hope that elimination of HIV-1 can be achieved, several approaches to reach a functional cure (control of HIV-1 replic
Externí odkaz:
https://doaj.org/article/49b43cc6afd84590a72198e44df1ca50
Autor:
Robert J Scarborough, Michel V Lévesque, Etienne Boudrias-Dalle, Ian C Chute, Sylvanne M Daniels, Rodney J Ouellette, Jean-Pierre Perreault, Anne Gatignol
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 3, Iss C (2014)
Antisense-based molecules targeting HIV-1 RNA have the potential to be used as part of gene or drug therapy to treat HIV-1 infection. In this study, HIV-1 RNA was screened to identify more conserved and accessible target sites for ribozymes based on
Externí odkaz:
https://doaj.org/article/0d19bd4acfa544378dbcabd3f120b122
Autor:
Noëlla Arnaud, Stéphanie Dabo, Patrick Maillard, Agata Budkowska, Katerina I Kalliampakou, Penelope Mavromara, Dominique Garcin, Jacques Hugon, Anne Gatignol, Daisuke Akazawa, Takaji Wakita, Eliane F Meurs
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10575 (2010)
Hepatitis C virus is a poor inducer of interferon (IFN), although its structured viral RNA can bind the RNA helicase RIG-I, and activate the IFN-induction pathway. Low IFN induction has been attributed to HCV NS3/4A protease-mediated cleavage of the
Externí odkaz:
https://doaj.org/article/bed02c5ca7014576bb11fe7b1fbd733a
Autor:
Damien Vitour, Sébastien Nisole, Nicolas Lévêque, Aure Saulnier, Noël Tordo, Anne Gatignol, David Gilmer
Publikováno v:
Virologie. 26:405-408
Publikováno v:
Expert Opinion on Drug Discovery. 18:163-179
Long-term control of HIV-1 infection can potentially be achieved using autologous stem cell transplants with gene-modified cells. Non-coding RNAs represent a diverse class of therapeutic agents including ribozymes, RNA aptamers and decoys, small inte