Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Anne G. Rowlands"'
Autor:
Dennis J. Hlasta, Virendra Kumar, Kenneth C. Cundy, Malcolm R. Bell, Chakrapani Subramanyam, Alan L. Maycock, Ranjit C. Desai, E. Ferguson, A. J. Mura, C. A. Franke, Dunlap Richard Paul, Anne G. Rowlands, Robert J. Gordon, Shari L. Eiff, John J. Court
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:331-336
The lead compound for this SAR study, benzisothiazolone 1a, was a 15 nM inhibitor of HLE, but was unstable in human blood ( t 1 2 min). The introduction of lipophilic substituents at the R4-position such as ethyl or isopropyl and modulation of the el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea1155374a07808b26361338d78aa314
https://doi.org/10.1016/0960-894x(95)00030-w
https://doi.org/10.1016/0960-894x(95)00030-w
Autor:
Dennis J. Hlasta, E. Ferguson, Ranjit C. Desai, Chakrapani Subramanyam, Alan L. Maycock, Dunlap Richard Paul, Shari L. Eiff, A. J. Mura, Robert J. Gordon, Anne G. Rowlands, Kenneth C. Cundy, Malcolm R. Bell, John J. Court, C. A. Franke, Virendra Kumar
Publikováno v:
ChemInform. 26
The lead compound for this SAR study, benzisothiazolone 1a, was a 15 nM inhibitor of HLE, but was unstable in human blood ( t 1 2 min). The introduction of lipophilic substituents at the R4-position such as ethyl or isopropyl and modulation of the el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15be6cc92564170d7f96d0366aba8a08
https://doi.org/10.1002/chin.199529160
https://doi.org/10.1002/chin.199529160
Autor:
Sandhya Subramanian, Virendra Kumar, Catherine A. Franke, Dunlap Richard Paul, Dennis J. Hlasta, Malcolm R. Bell, Edward Ferguson, Anne G. Rowlands, Judith A. Johnson, John J. Court, David Robinson, Manohar Saindane, Marion L. Drozd, Chakrapani Subramanyam, Alan L. Maycock, Karl R. Mueller, W. Mark Eickhoff, Paul J. Silver, Albert J. Mura, Edward D. Pagani, Robert J. Gordon, Ranjit C. Desai, Philip M. Carabateas
Publikováno v:
Journal of medicinal chemistry. 38(5)
Human leukocyte elastase (HLE) has been proposed as a primary mediator of pulmonary emphysema and other inflammatory airway diseases. HLE is capable of cleaving many proteins, including elastin, other components of connective tissue, certain compleme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cd72bd054d626ee601414321d310026
https://pubmed.ncbi.nlm.nih.gov/7877139
https://pubmed.ncbi.nlm.nih.gov/7877139
Publikováno v:
European journal of biochemistry. 175(1)
Previously, we have shown that phosphorylation of the eukaryotic initiation factor eIF-2 alpha increases under several physiological stresses in which protein synthesis is inhibited in Ehrlich ascites tumor cells. As phosphorylated eIF-2 [eIF-2(alpha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99677e826d503d729d05418ee1cce7e5
https://pubmed.ncbi.nlm.nih.gov/3402451
https://pubmed.ncbi.nlm.nih.gov/3402451