Widespread overexpression from the four DNA hypermethylated HOX clusters in aggressive (IDHwt) glioma is associated with H3K27me3 depletion and alternative promoter usage

Autor: Elisa Le Boiteux, Franck Court, Pierre‐Olivier Guichet, Catherine Vaurs‐Barrière, Isabelle Vaillant, Emmanuel Chautard, Pierre Verrelle, Bruno M. Costa, Lucie Karayan‐Tapon, Anne Fogli, Philippe Arnaud

Publikováno v: Molecular Oncology, Vol 15, Iss 8, Pp 1995-2010 (2021)

In human, the 39 coding HOX genes and 18 referenced noncoding antisense transcripts are arranged in four genomic clusters named HOXA, B, C, and D. This highly conserved family belongs to the homeobox class of genes that encode transcription factors r

Externí odkaz: https://doaj.org/article/fed95548f2564556b60979aca372b0ee

The Long Non-Coding RNA HOXA-AS2 Promotes Proliferation of Glioma Stem Cells and Modulates Their Inflammation Pathway Mainly through Post-Transcriptional Regulation

Autor: Elisa Le Boiteux, Pierre-Olivier Guichet, Konstantin Masliantsev, Bertille Montibus, Catherine Vaurs-Barriere, Céline Gonthier-Gueret, Emmanuel Chautard, Pierre Verrelle, Lucie Karayan-Tapon, Anne Fogli, Franck Court, Philippe Arnaud

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 9, p 4743 (2022)

Glioblastomas represent approximatively half of all gliomas and are the most deadly and aggressive form. Their therapeutic resistance and tumor relapse rely on a subpopulation of cells that are called Glioma Stem Cells (GSCs). Here, we investigated t

Externí odkaz: https://doaj.org/article/eaa16bcefe1a4cf78d9d79e9ad983d0e

Developmental splicing deregulation in leukodystrophies related to EIF2B mutations.

Autor: Aurélia Huyghe, Laetitia Horzinski, Alain Hénaut, Marina Gaillard, Enrico Bertini, Raphael Schiffmann, Diana Rodriguez, Yann Dantal, Odile Boespflug-Tanguy, Anne Fogli

Publikováno v: PLoS ONE, Vol 7, Iss 6, p e38264 (2012)

Leukodystrophies (LD) are rare inherited disorders that primarily affect the white matter (WM) of the central nervous system. The large heterogeneity of LD results from the diversity of the genetically determined defects that interfere with glial cel

Externí odkaz: https://doaj.org/article/5be6a3cc0b9947c2b6c49ec84b1bb74c

Eukaryotic initiation factor 2B (eIF2B) GEF activity as a diagnostic tool for EIF2B-related disorders.

Autor: Laetitia Horzinski, Aurélia Huyghe, Marie-Céleste Cardoso, Céline Gonthier, Lemlih Ouchchane, Raphael Schiffmann, Pierre Blanc, Odile Boespflug-Tanguy, Anne Fogli

Publikováno v: PLoS ONE, Vol 4, Iss 12, p e8318 (2009)

BACKGROUND:In recent years, the phenotypes of leukodystrophies linked to mutations in the eukaryotic initiation factor 2B genes have been extended, classically called CACH/VWM (Childhood ataxia with cntral hypomyélination/vanishing white matter diso

Externí odkaz: https://doaj.org/article/d760b38a1a4c42c48667ec3ef1b6fec1

Transcriptional alterations in glioma result primarily from DNA methylation–independent mechanisms

Autor: Mélanie Müller-Barthélémy, Elisa Le Boiteux, Franck Court, Julian Biau, Lucie Karayan-Tapon, Toufic Khalil, Pierre Verrelle, Philippe Arnaud, Jean-Louis Kemeny, Anne Fogli, Catherine Vaurs-Barrière, Bruno Pereira, Emmanuel Chautard

Publikováno v: Genome Research
Genome Research, 2019, 29 (10), pp.1605-1621. ⟨10.1101/gr.249219.119⟩
Genome Research, Cold Spring Harbor Laboratory Press, 2019, 29 (10), pp.1605-1621. ⟨10.1101/gr.249219.119⟩

In cancer cells, aberrant DNA methylation is commonly associated with transcriptional alterations, including silencing of tumor suppressor genes. However, multiple epigenetic mechanisms, including polycomb repressive marks, contribute to gene deregul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a976cd21f9127bb91cbb3859bc871cd6
https://doi.org/10.1101/gr.249219.119