Predicted Loop Regions Promote Aggregation: A Study of Amyloidogenic Domains in the Functional Amyloid FapC

Autor: Brian S. Vad, Jan Skov Pedersen, Andreas Bøggild, Madhu Nagaraj, Mumdooh Ahmed, Jeppe Lyngsø, Anne Fillipsen, Daniel E. Otzen, Ümit Akbey

Publikováno v: Nagaraj, M, Ahmed, M, Lyngsø, J, Vad, B S, Bøggild, A, Fillipsen, A, Pedersen, J S, Otzen, D E & Akbey, Ü 2020, ' Predicted Loop Regions Promote Aggregation : A Study of Amyloidogenic Domains in the Functional Amyloid FapC ', Journal of Molecular Biology, vol. 432, no. 7, pp. 2232-2252 . https://doi.org/10.1016/j.jmb.2020.01.044

Protein fibrillation is traditionally associated with misfolding, loss of functional phenotype, and gain of toxicity in neurodegenerative diseases. However, many organisms exploit fibrils in the form of functional amyloids (FA), as seen in bacteria,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0f60043b5fcda772fa980ff6e8364c
https://doi.org/10.1016/j.jmb.2020.01.044