Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Anne E. O'Connor"'
Autor:
Brendan J. Houston, Joseph Nguyen, D. Jo Merriner, Anne E. O’Connor, Alexandra M. Lopes, Liina Nagirnaja, Corinna Friedrich, Sabine Kliesch, Frank Tüttelmann, Kenneth I. Aston, Donald F. Conrad, Robin M. Hobbs, Jessica E. M. Dunleavy, Moira K. O’Bryan
Publikováno v:
Cell Death and Disease, Vol 15, Iss 7, Pp 1-14 (2024)
Abstract Dynein complexes are large, multi-unit assemblies involved in many biological processes via their critical roles in protein transport and axoneme motility. Using next-generation sequencing of infertile men presenting with low or no sperm in
Externí odkaz:
https://doaj.org/article/38d67cff45b24f41b04e0df254fa2667
Autor:
Brendan J. Houston, Manon S. Oud, Daniel M. Aguirre, D. Jo Merriner, Anne E. O’Connor, Ozlem Okutman, Stéphane Viville, Richard Burke, Joris A. Veltman, Moira K. O’Bryan
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 12, Pp 4449-4457 (2020)
Externí odkaz:
https://doaj.org/article/a7a59dd16d164fee95bf95fa6b6d41d2
Autor:
Avinash S. Gaikwad, Amanda L. Anderson, D. Jo Merriner, Anne E. O’Connor, Brendan J. Houston, R. John Aitken, Moira K. O’Bryan, Brett Nixon
Publikováno v:
BMC Biology, Vol 17, Iss 1, Pp 1-18 (2019)
Abstract Background The sperm protein IZUMO1 (Izumo sperm-egg fusion 1) and its recently identified binding partner on the oolemma, IZUMO1R, are among the first ligand-receptor pairs shown to be essential for gamete recognition and adhesion. However,
Externí odkaz:
https://doaj.org/article/c0dd1d0c4ccf4482bcdb143e83fca199
Autor:
Avinash S. Gaikwad, Ashwin Nandagiri, David L. Potter, Reza Nosrati, Anne E. O’Connor, Sameer Jadhav, Julio Soria, Ranganathan Prabhakar, Moira K. O’Bryan
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Fertilization requires sperm to travel long distances through the complex environment of the female reproductive tract. Despite the strong association between poor motility and infertility, the kinetics of sperm tail movement and the role individual
Externí odkaz:
https://doaj.org/article/9208e1ecf74d43ef878a887dfc9a928e
Autor:
Almas R. Juma, Sylvia V. H. Grommen, Moira K. O’Bryan, Anne E. O’Connor, D. Jo Merriner, Nathan E. Hall, Stephen R. Doyle, Pauliina E. Damdimopoulou, Daniel Barriga, Adam H. Hart, Wim J. M. Van de Ven, Bert De Groef
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Deficiency in pleomorphic adenoma gene 1 (PLAG1) leads to reduced fertility in male mice, but the mechanism by which PLAG1 contributes to reproduction is unknown. To investigate the involvement of PLAG1 in testicular function, we determined
Externí odkaz:
https://doaj.org/article/f9a9c5dca672498dbf31f37666823195
Autor:
Brendan J. Houston, Alexandra M. Lopes, Maris Laan, Liina Nagirnaja, Anne E. O'Connor, D. Jo Merriner, Joseph Nguyen, Margus Punab, Antoni Riera-Escamilla, Csilla Krausz, Kenneth Ivan Aston, Donald F. Conrad, Moira K. O'Bryan
Publikováno v:
DEVELOPMENTAL BIOLOGY
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Male infertility is a common condition affecting at least 7% of men worldwide and is often genetic in origin. Using whole exome sequencing, we recently discovered three hemizygous, likely damaging variants in DDB1- and CUL4-associated factor 12-like
Autor:
Samuel R. Cheers, Anne E. O’Connor, Travis K. Johnson, D. Jo Merriner, Moira K. O’Bryan, Jessica E. M. Dunleavy
Publikováno v:
Development. 150
The development and function of male gametes is critically dependent on a dynamic microtubule network, yet how this is regulated remains poorly understood. We have recently shown that microtubule severing, via the action of the meiotic AAA ATPase pro
Autor:
Brendan J. Houston, D. Jo Merriner, G. Gemma Stathatos, Anne E. O’Connor, Alexandra M. Lopes, Donald F. Conrad, Mark Baker, Jessica E.M. Dunleavy, Moira K. O’Bryan
The transition zone is a specialised gate at the base of cilia/flagella, which segregates the ciliary compartment from the cytoplasm and strictly regulates protein entry. In this study, we have identified CEP76 as an essential germ cell transition zo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::079320534b1c4bfab755a5b6ba87487f
https://doi.org/10.1101/2023.03.08.531794
https://doi.org/10.1101/2023.03.08.531794
Autor:
Jessica EM Dunleavy, Maddison Graffeo, Kathryn Wozniak, Anne E O’Connor, D. Jo Merriner, Joseph Nguyen, Ralf B Schittenhelm, Brendan J Houston, Moira K O’Bryan
SummaryKatanin microtubule severing enzymes are potent M-phase regulators in oocytes and somatic cells. How the complex, and evolutionarily critical, male mammalian meiotic spindle is sculpted remains unknown. Here, using multiple single and double g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1756166c7c1b055cbd32c16be5e97771
https://doi.org/10.1101/2022.11.11.516072
https://doi.org/10.1101/2022.11.11.516072
Autor:
Richard Burke, Manon S. Oud, Anne E O'Connor, Ozlem Okutman, Daniel M Aguirre, Brendan J Houston, Moira K O'Bryan, Stéphane Viville, Joris A. Veltman, D. Jo Merriner
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 12, Pp 4449-4457 (2020)
G3: Genes|Genomes|Genetics
G3, 10, 12, pp. 4449-4457
G3, 10, 4449-4457
G3: Genes|Genomes|Genetics
G3, 10, 12, pp. 4449-4457
G3, 10, 4449-4457
Contains fulltext : 229297.pdf (Publisher’s version ) (Open Access) Globozoospermia is a rare form of male infertility where men produce round-headed sperm that are incapable of fertilizing an oocyte naturally. In a previous study where we undertoo