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pro vyhledávání: '"Anne E. Mercier"'
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 1, Pp n/a-n/a (2024)
Abstract The generation of tissue from stem cells is an alluring concept as it holds a number of potential applications in clinical therapeutics and regenerative medicine. Mesenchymal stromal/stem cells (MSCs) can be isolated from a number of differe
Externí odkaz:
https://doaj.org/article/16897b10e3754a66b6d702c40b42b8a5
Autor:
Scott D. Hargrave, Anna M. Joubert, Barry V. L. Potter, Wolfgang Dohle, Sumari Marais, Anne E. Mercier
Publikováno v:
Molecules, Vol 27, Iss 12, p 3819 (2022)
A tetrahydroisoquinoline (THIQ) core is able to mimic the A and B rings of 2-methoxyestradiol (2ME2), an endogenous estrogen metabolite that demonstrates promising anticancer properties primarily by disrupting microtubule dynamic instability paramete
Externí odkaz:
https://doaj.org/article/2684b04f1f7c4b30b6276ffafcb5e169
Autor:
Anne E. Mercier, Renaud Prudent, Michael S. Pepper, Leanne De Koning, Elsie Nolte, Lauralie Peronne, Marcel Nel, Laurence Lafanechère, Anna M. Joubert
Publikováno v:
Molecules, Vol 26, Iss 3, p 706 (2021)
The search for novel anti-cancer compounds which can circumvent chemotherapeutic drug resistance and limit systemic toxicity remains a priority. 2-Ethyl-3-O-sulphamoyl-estra-1,3,5(10)15-tetraene-3-ol-17one (ESE-15-one) and 2-ethyl-3-O-sulphamoyl-estr
Externí odkaz:
https://doaj.org/article/01728ee26385460c91981320dc8a7c59
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 10, p 2887 (2018)
Following exposure of cells to gamma-radiation, a cascade of intracellular consequences may be observed in a semitemporal manner. This includes deoxyribonucleic acid (DNA) damage and reactive oxygen species (ROS) accumulation initially, with conseque
Externí odkaz:
https://doaj.org/article/a04eca2730b44f2b90c3440c5df8ee47
Publikováno v:
Advances in experimental medicine and biology. 1083
The recurrence and/or lack of response of certain tumors to radio- and chemotherapy has been attributed to a small subpopulation of cells termed cancer stem cells (CSCs). CSCs have been identified in many tumors (including solid and hematological tum