A platform for glycoengineering a polyvalent pneumococcal bioconjugate vaccine using E. coli as a host

Autor: Christian M. Harding, Mohamed A. Nasr, Nichollas E. Scott, Guillaume Goyette-Desjardins, Harald Nothaft, Anne E. Mayer, Sthefany M. Chavez, Jeremy P. Huynh, Rachel L. Kinsella, Christine M. Szymanski, Christina L. Stallings, Mariela Segura, Mario F. Feldman

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)

Bioconjugation is a promising process to manufacture conjugate vaccines, but currently employed enzymes cannot generate the full spectrum of bacterial glycoproteins. Here, the authors use an O-linking oligosaccharyltransferase to generate a polyvalen

Externí odkaz: https://doaj.org/article/def4f3d9176a44dbb8129ca597b1866c

Noroviruses Co-opt the Function of Host Proteins VAPA and VAPB for Replication via a Phenylalanine–Phenylalanine-Acidic-Tract-Motif Mimic in Nonstructural Viral Protein NS1/2

Autor: Broc T. McCune, Wei Tang, Jia Lu, James B. Eaglesham, Lucy Thorne, Anne E. Mayer, Emily Condiff, Timothy J. Nice, Ian Goodfellow, Andrzej M. Krezel, Herbert W. Virgin

Publikováno v: mBio, Vol 8, Iss 4 (2017)

ABSTRACT The Norovirus genus contains important human pathogens, but the role of host pathways in norovirus replication is largely unknown. Murine noroviruses provide the opportunity to study norovirus replication in cell culture and in small animals

Externí odkaz: https://doaj.org/article/c14f5cf474dd4ad49e80a9614b687337

A promising bioconjugate vaccine against hypervirulent Klebsiella pneumoniae

Autor: Feldman, Mario F., Bridwell, Anne E. Mayer, Scott, Nichollas E., Vinogradov, Evgeny, McKee, Samuel R., Chavez, Sthefany M., Twentyman, Joy, Stallings, Christina L., Rosen, David A., Harding, Christian M.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2019 Sep 01. 116(37), 18655-18663.

Externí odkaz: https://www.jstor.org/stable/26851956

A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells

Autor: Dong Hee Chung, Partha Karmakar, Michael A Tartell, Andrea M. Klingler, Vishnu C. Damalanka, Markus Hoffmann, Cassandra E Thompson, Sean P. J. Whelan, Matthew Mahoney, Stefan Pöhlmann, Paul W. Rothlauf, Melody Lee, Jorine Voss, Anthony J. O’Donoghue, André Luiz Lourenço, Charles S. Craik, Christina L. Stallings, Marc E. Rothenberg, James W. Janetka, Nurit P. Azouz, Anne E. Mayer Bridwell, Dustin Pwee, Lidija Klampfer

Publikováno v: bioRxiv
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 43
Proceedings of the National Academy of Sciences of the United States of America

Significance MM3122 represents an advanced lead candidate for clinical development as a novel antiviral drug for COVID-19. In addition to being novel drugs, these selective TMRSS2 inhibitors can be used as valuable chemical probes to help elucidate m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375bc698f0a068ad5bcd60e5bac8a49a
https://europepmc.org/articles/PMC8204910/

Identification of 4-Amino-Thieno[2,3- Mycobacterium tuberculosis

Autor: Rachel L. Kinsella, Scott A. Wildman, Marvin J. Meyers, Kelly Flentie, Margaret Gaggioli, Megh Singh, Leslie A. Weiss, Janessa S. Aneke, Christina L. Stallings, Miranda E. Schene, Anne E. Mayer Bridwell, Gregory A. Harrison, Keshav Jayaraman, Samantha D. Solomon

Publikováno v: mSphere, Vol 4, Iss 5 (2019)
mSphere, Vol 4, Iss 5, p e00606-19 (2019)
mSphere

The global tuberculosis (TB) epidemic has been exacerbated by the rise in drug-resistant TB cases worldwide. To tackle this crisis, it is necessary to identify new vulnerable drug targets in Mycobacterium tuberculosis, the causative agent of TB, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d6285d8cd99eafdaf5c8e6d40ec5001
https://journals.asm.org/doi/10.1128/mSphere.00606-19