Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Anne E. Fray"'
Publikováno v:
Neuroscience. 109:27-44
A monoclonal antibody to excitatory amino acid transporter 1 (EAAT1) has been generated which robustly stains paraffin-embedded, formaldehyde-fixed as well as snap-frozen human post-mortem brain tissue. We have used this antibody to map the distribut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b61b64cd6738ead7cc432d6dbc62c16
https://doi.org/10.1016/s0306-4522(01)00437-7
https://doi.org/10.1016/s0306-4522(01)00437-7
Publikováno v:
Molecular Brain Research. 94:131-136
The expression and activity of the enzyme glutamine synthetase (GS) were examined in the G93A/SOD-1 transgenic mouse model of progressive motor neuronopathy to investigate the mechanisms underlying degeneration of the motor neurones. Clinical signs a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e8562f25963bb25c29f58d3ace77de
https://doi.org/10.1016/s0169-328x(01)00228-5
https://doi.org/10.1016/s0169-328x(01)00228-5
Autor:
Ian D. Milton, Mark R. Cookson, Steven J. Banner, Pamela J. Shaw, Philip A. Usher, Paul G. Ince, Anne E. Fray
Publikováno v:
European Journal of Neuroscience. 10:2481-2489
Emerging evidence suggests that a disturbance of the glutamate neurotransmitter system may be a contributory factor to motor neuron injury in motor neuron disease. Previous autoradiographic and immunoblotting studies have suggested that there may be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1812e7a17713a3e3cdea8653894539ee
https://doi.org/10.1046/j.1460-9568.1998.00273.x
https://doi.org/10.1046/j.1460-9568.1998.00273.x
Publikováno v:
The Journal of Physiology. 504:721-726
1. Steady-state and time-resolved quantitative microdialysis was used to measure dialysate concentration, extracellular concentration and the in vivo recovery of glucose in rat striatum. 2. The extracellular concentration of glucose, determined by th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e2cd42c3a7e42a4486fb8b2b37b702d
https://doi.org/10.1111/j.1469-7793.1997.721bd.x
https://doi.org/10.1111/j.1469-7793.1997.721bd.x
Cultured glial cells are resistant to the effects of motor neurone disease-associated SOD1 mutations
Autor:
Denise A. Figlewicz, Anne E. Fray, Pamela J. Shaw, Fiona M. Menzies, Phillip M. Manning, Mark R. Cookson, Rebecca Williams
Publikováno v:
Neuroscience letters. 302(2-3)
Free radical damage has been implicated in the pathophysiology of motor neurone disease (MND); mutations have been identified in the gene encoding Cu/Zn superoxide dismutase (SOD1). There is evidence that glial cell dysfunction may contribute to moto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3edfeea2533c829b27d6d392f861d25b
https://pubmed.ncbi.nlm.nih.gov/11290408
https://pubmed.ncbi.nlm.nih.gov/11290408
Autor:
Paul G. Ince, Georg Grön, Anne E. Fray, Birgit Schwalenstöcker, Christoph Münch, Thomas Meyer, Pamela J. Shaw, Stefan Stamm, Andrea Fromm, Albert C. Ludolph
Publikováno v:
Journal of the neurological sciences. 170(1)
Impaired re-uptake of synaptic glutamate, and a reduced expression of the glutamate transporter EAAT2 have been found in the motor cortex of patients with amyotrophic lateral sclerosis (ALS). Two splice forms of the EAAT2 RNA resulting from retention
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de41a055ea8d500bae8e6304f49345be
https://pubmed.ncbi.nlm.nih.gov/10540035
https://pubmed.ncbi.nlm.nih.gov/10540035
Autor:
Pamela J. Shaw, Paul G. Ince, N.M. Thatcher, C. H. W. Horne, Steven J. Banner, Anne E. Fray, I. D. Milton, Nigel H. Piggott
Publikováno v:
Brain research. Molecular brain research. 52(1)
Glutamate transporters play an essential role in terminating the excitatory glutamatergic signal at post-synaptic receptors and in protecting neurones from excitotoxic effects, as well as replenishing the neurotransmitter supply at glutamatergic syna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c6a8bf984a2c6874fa3bbe9cc923959
https://pubmed.ncbi.nlm.nih.gov/9450673
https://pubmed.ncbi.nlm.nih.gov/9450673