Rescue of inhibitory synapse strength following developmental hearing loss.

Autor: Vibhakar C Kotak, Anne E Takesian, Patricia C MacKenzie, Dan H Sanes

Publikováno v: PLoS ONE, Vol 8, Iss 1, p e53438 (2013)

Inhibitory synapse dysfunction may contribute to many developmental brain disorders, including the secondary consequences of sensory deprivation. In fact, developmental hearing loss leads to a profound reduction in the strength of inhibitory postsyna

Externí odkaz: https://doaj.org/article/c20929455f864b3a92d664e1d2b3e160

Sensitive period-regulating genetic pathways and exposure to adversity shape risk for depression

Autor: Kathryn A. Davis, Jordan W. Smoller, Anne E. Takesian, Juan Carlos Ramírez-Tapia, Alexandre A. Lussier, Takao K. Hensch, Katherine Crawford, Min-Jung Wang, Christiaan de Leeuw, Yiwen Zhu, Erin C. Dunn

Publikováno v: Neuropsychopharmacology
Neuropsychopharmacology, 47(2), 497-506. Nature Publishing Group
Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium 2022, ' Sensitive period-regulating genetic pathways and exposure to adversity shape risk for depression ', Neuropsychopharmacology, vol. 47, no. 2, pp. 497-506 . https://doi.org/10.1038/s41386-021-01172-6
Zhu, Y, Wang, M-J, Crawford, K M, Ramírez-Tapia, J C, Lussier, A A, Davis, K A, de Leeuw, C, Takesian, A E, Hensch, T K, Smoller, J W, Dunn, E C & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium 2022, ' Sensitive period-regulating genetic pathways and exposure to adversity shape risk for depression ', Neuropsychopharmacology, vol. 47, no. 2, pp. 497-506 . https://doi.org/10.1038/s41386-021-01172-6

Animal and human studies have documented the existence of developmental windows (or sensitive periods) when experience can have lasting effects in shaping brain structure or function, behavior, and disease risk. Sensitive periods for depression likel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51261dd331a370fabb9657c8bcdc0093
https://europepmc.org/articles/PMC8674315/

Regulation of auditory plasticity during critical periods and following hearing loss

Autor: Dora Persic, David K. Ryugo, Sonja J. Pyott, Vassilis Pelekanos, Maryse E. Thomas, Katrin Krumbholz, Anne E. Takesian

Publikováno v: Hearing Research

Sensory input has profound effects on neuronal organization and sensory maps in the brain. The mechanisms regulating plasticity of the auditory pathway have been revealed by examining the consequences of altered auditory input during both development

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c290becaf858ae4b83be750d12082608

NMDA 2A receptors in parvalbumin cells mediate sex-specific rapid ketamine response on cortical activity

Autor: Michela Fagiolini, Anne E. Takesian, Takao K. Hensch, Nathalie Picard

Publikováno v: Molecular Psychiatry

Ketamine has emerged as a widespread treatment for a variety of psychiatric disorders when used at sub-anesthetic doses, but the neural mechanisms underlying its acute action remain unclear. Here, we identified NMDA receptors containing the 2A subuni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0b48172c8b582b7407455d0ec4ea0ea
https://pubmed.ncbi.nlm.nih.gov/30696941

Inhibitory circuit gating of auditory critical-period plasticity

Autor: Jeff W. Lichtman, Luke J Bogart, Takao K. Hensch, Anne E. Takesian

Publikováno v: Nature neuroscience

Cortical sensory maps are remodeled during early life to adapt to the surrounding environment. Both sensory and contextual signals are important for induction of this plasticity, but how these signals converge to sculpt developing thalamocortical cir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d198c6b5f21ba6561272b1721cfc298
https://pubmed.ncbi.nlm.nih.gov/29915196