Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Anne E Kiltie"'
Autor:
Anne E Kiltie, Fatima Asim, Lowenna Clarke, Elizabeth Donnelly, Fouzia Rahana Jamal, Lucrezia Maria Piccicacchi, Mahanoor Qadir, Nain Tara Raja, Cyrus Samadi, Chee Kin Then
Publikováno v:
BMJ Oncology, Vol 2, Iss 1 (2023)
Cancer remains one of the leading causes of death worldwide, despite advances in treatments such as surgery, chemotherapy, radiotherapy and immunotherapy. The role of the gut microbiota in human health and disease, particularly in relation to cancer
Externí odkaz:
https://doaj.org/article/f9e684992bc64bfe9b82562afdf5feee
Autor:
Edward C Ottley, Robert Pell, Benedict Brazier, Julianne Hollidge, Christiana Kartsonaki, Lisa Browning, Eric O'Neill, Anne E Kiltie
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 6, Iss 4, Pp 238-251 (2020)
Abstract Approximately 75% of bladder cancers are non‐muscle invasive (NMIBC). Of these, up to 53% of cases progress to life‐threatening muscle‐invasive bladder cancer (MIBC). Patients with high‐grade stage T1 (HGT1) NMIBC frequently undergo
Externí odkaz:
https://doaj.org/article/63751b5357d0404a90b79fbc7bbc3d86
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 29, Iss , Pp 11-19 (2021)
Background and purpose: Pelvic radiotherapy (RT) often results in gastrointestinal toxicity and clinical trials have demonstrated a potential benefit of dietary supplements in alleviating acute effects. However, no prophylactic agents have been appro
Externí odkaz:
https://doaj.org/article/b68ae72b469d40178db5f9868249759f
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-5 (2021)
Externí odkaz:
https://doaj.org/article/31b9b4bfc2cd4b18ab4009f1bbd49cdc
Autor:
Juri Na, Joseph A. Newman, Chee Kin Then, Junetha Syed, Iolanda Vendrell, Ignacio Torrecilla, Sophie Ellermann, Kristijan Ramadan, Roman Fischer, Anne E. Kiltie
Publikováno v:
Cell Death and Disease, Vol 12, Iss 2, Pp 1-17 (2021)
Abstract The human MRE11/RAD50/NBS1 (MRN) complex plays a crucial role in sensing and repairing DNA DSB. MRE11 possesses dual 3′−5′ exonuclease and endonuclease activity and forms the core of the multifunctional MRN complex. We previously ident
Externí odkaz:
https://doaj.org/article/3103fd513d43413eb4a4915b79d69200
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-16 (2020)
Abstract Background Patients with pelvic malignancies often receive radiosensitising chemotherapy with radiotherapy to improve survival; however, this is at the expense of increased normal tissue toxicity, particularly in elderly patients. Here, we e
Externí odkaz:
https://doaj.org/article/77a272ce5bf44432af56ed568e95b14c
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100978- (2021)
Summary: DNA end resection converts broken ends of double-stranded DNA (dsDNA) to 3′-single-stranded DNA (3′-ssDNA). The extent of resection regulates DNA double-strand break (DSB) repair pathway choice and thereby genomic stability. Here, we cha
Externí odkaz:
https://doaj.org/article/df88efb6bb6f41ffabbd89d98ecc3a22
Autor:
Anne E. Kiltie, Martin Kerr, Cheryl L. Scudamore, Ester M. Hammond, Sarah J. Jevons, Michael R.L. Stratford, James Thompson, Selvakumar Anbalagan, Jacqueline Kelly, Judith Nicholson, Jessica Gorrill, Helen Scott, Jia-Ling Ruan, Blaz Groselj
Treating mice vertically head-down in the SARRP. Preliminary experiments on freshly dead mice, irradiated then immediately subjected to autopsy, demonstrated that small bowel is at a safe distance from the field edge.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::370152db82cd00a460bcf27dfb019c46
https://doi.org/10.1158/1535-7163.22505328.v1
https://doi.org/10.1158/1535-7163.22505328.v1
Autor:
Anne E. Kiltie, Martin Kerr, Cheryl L. Scudamore, Ester M. Hammond, Sarah J. Jevons, Michael R.L. Stratford, James Thompson, Selvakumar Anbalagan, Jacqueline Kelly, Judith Nicholson, Jessica Gorrill, Helen Scott, Jia-Ling Ruan, Blaz Groselj
Panobinostat levels following IP and IV administration. Six h after injection of PAN 10 mg/kg IP or IV, plasma and selected organs were removed and PAN concentrations determined using HPLC.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d7f7f5aa1dfe53b5a6642093ff1b8aa
https://doi.org/10.1158/1535-7163.22505313
https://doi.org/10.1158/1535-7163.22505313
Autor:
Anne E. Kiltie, Martin Kerr, Cheryl L. Scudamore, Ester M. Hammond, Sarah J. Jevons, Michael R.L. Stratford, James Thompson, Selvakumar Anbalagan, Jacqueline Kelly, Judith Nicholson, Jessica Gorrill, Helen Scott, Jia-Ling Ruan, Blaz Groselj
As the population ages, more elderly patients require radiotherapy-based treatment for their pelvic malignancies, including muscle-invasive bladder cancer, as they are unfit for major surgery. Therefore, there is an urgent need to find radiosensitizi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81936d3c4bbc6917bb40d3d57a695170
https://doi.org/10.1158/1535-7163.c.6538026.v1
https://doi.org/10.1158/1535-7163.c.6538026.v1