Data from Relevance of Molecular Groups in Children with Newly Diagnosed Atypical Teratoid Rhabdoid Tumor: Results from Prospective St. Jude Multi-institutional Trials

Autor: Amar Gajjar, David W. Ellison, Marcel Kool, Thomas E. Merchant, Frederick A. Boop, Kim E. Nichols, Daniel J. Indelicato, Zoltan Patay, Paul Klimo, Robert P. Sanders, Roya Mostafavi, Sridharan Gururangan, Eric Bouffet, Murali Chintagumpala, John R. Crawford, Paul G. Fisher, Sonia Partap, Tim Hassall, Anne E. Bendel, Gregory T. Armstrong, Anna Vinitsky, Ibrahim Qaddoumi, Alberto Broniscer, Ashok Srinivasan, Sandeep Kumar Dhanda, Ruth G. Tatevossian, Catherine A. Billups, Gang Wu, Pascal Johann, Brent A. Orr, Arzu Onar-Thomas, Giles W. Robinson, Santhosh A. Upadhyaya

Purpose:Report relevance of molecular groups to clinicopathologic features, germline SMARCB1/SMARCA4 alterations (GLA), and survival of children with atypical teratoid rhabdoid tumor (ATRT) treated in two multi-institutional clinical trials.Materials

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b29fb4f16e48c14f46b5194fc53bbec
https://doi.org/10.1158/1078-0432.c.6530039

Phase II study of alisertib as a single agent for treating recurrent or progressive atypical teratoid/rhabdoid tumor

Autor: Santhosh A Upadhyaya, Olivia Campagne, Catherine A Billups, Brent A Orr, Arzu Onar-Thomas, Ruth G Tatevossian, Roya Mostafavi, Jason R Myers, Anna Vinitsky, Daniel C Moreira, Holly B Lindsay, Lindsay Kilburn, Patricia Baxter, Amy Smith, John R Crawford, Sonia Partap, Anne E Bendel, Dolly G Aguilera, Kim E Nichols, Evadnie Rampersaud, David W Ellison, Paul Klimo, Zoltan Patay, Giles W Robinson, Alberto Broniscer, Clinton F Stewart, Cynthia Wetmore, Amar Gajjar

Publikováno v: Neuro Oncol

Background Recurrent atypical teratoid/rhabdoid tumor (AT/RT) is, most often, a fatal pediatric malignancy with limited curative options. Methods We conducted a phase II study of Aurora kinase A inhibitor alisertib in patients aged Results SD (n = 8)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c400220e0abaea4f5202360fbc76cf7
https://europepmc.org/articles/PMC9925713/

HGG-11. Clinical characteristics and clinical evolution of a large cohort of pediatric patients with primary central nervous system (CNS) tumors and tropomyosin receptor kinase (TRK) fusion

Autor: Audrey-Anne Lamoureux, Michael Fisher, Lauriane Lemelle, Elke Pfaff, Christof Kramm, Bram De Wilde, Bernarda Kazanowska, Caroline Hutter, Stefan M Pfister, Dominik Sturm, David Jones, Daniel Orbach, Gaëlle Pierron, Scott Raskin, Alexander Drilon, Eli Diamond, Guilherme Harada, Michal Zapotocky, Benjamin Ellezam, Alexander G Weil, Dominic Venne, Marc Barritault, Pierre Leblond, Hallie Coltin, Rawan Hammad, Uri Tabori, Cynthia Hawkins, Jordan R Hansford, Deborah Meyran, Craig Erker, Kathryn McFadden, Mariko Sato, Nicholas G Gottardo, Hetal Dholaria, Dorte Schou Nørøxe, Hiroaki Goto, David S Ziegler, Frank Y Lin, Donald Williams Parsons, Holly Lindsay, Tai-Tong Wong, Yen-Lin Liu, Kuo-Sheng Wu, Andrea Flynn Franson, Eugene Hwang, Ana Aguilar-Bonilla, Sylvia Cheng, Chantel Cacciotti, Maura Massimino, Elisabetta Schiavello, Paul Wood, Lindsey M Hoffman, Andréa Cappellano, Alvaro Lassaletta, An Van Damme, Anna Llort, Nicolas U Gerber, Mariella Spalato Ceruso, Anne E Bendel, Maggie Skrypek, Dima Hamideh, Naureen Mushtaq, Andrew Walter, Nada Jabado, Aysha Alsahlawi, Jean-Pierre Farmer, Christina Coleman Abadi, Sabine Mueller, Claire Mazewski, Dolly Aguilera, Nathan Robison, Katrina O’Halloran, Samuel Abbou, Pablo Berlanga, Birgit Geoerger, Ingrid Øra, Christopher L Moertel, Evangelia D Razis, Anastasia Vernadou, François Doz, Theodore W Laetsch, Sébastien Perreault

Publikováno v: Neuro-Oncology. 24:i61-i62

BACKGROUND: TRK fusions are detected in less than 3% of CNS tumors. Given their rarity, there are limited data on the clinical course of these patients. METHODS: We contacted 166 oncology centers worldwide to retrieve data on patients with TRK fusion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::70f58214dd53291eeabc1636fa6629a8
https://doi.org/10.1093/neuonc/noac079.226

Morphoproteomic confirmation of constitutively activated mTOR, ERK, and NF-kappaB pathways in Ewing family of tumors

Autor: Maryam J, Zenali, Ping L, Zhang, Anne E, Bendel, Robert E, Brown

Publikováno v: Annals of clinical and laboratory science. 39(2)

In 3 patients with the Ewing family of tumors (EFT), morphoproteomic analyses of the tumors revealed constitutive activation of the mTOR, ERK, and NF-kappaB pathways, as evidenced by: (a) expression of phosphorylated (p)-mTOR, p-p70S6K, p-ERK 1/2, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f8621115da93c1b4b0c178ee5983f8aa
https://pubmed.ncbi.nlm.nih.gov/19429803