Zobrazeno 1 - 10
of 203
pro vyhledávání: '"Anne E, Willis"'
Autor:
Ionel Sandovici, Denise S. Fernandez-Twinn, Niamh Campbell, Wendy N. Cooper, Yoichi Sekita, Ilona Zvetkova, David Ferland-McCollough, Haydn M. Prosser, Lila M. Oyama, Lucas C. Pantaleão, Danilo Cimadomo, Karina Barbosa de Queiroz, Cecilia S.K. Cheuk, Nicola M. Smith, Richard G. Kay, Robin Antrobus, Katharina Hoelle, Marcella K.L. Ma, Noel H. Smith, Stefan H. Geyer, Lukas F. Reissig, Wolfgang J. Weninger, Kenneth Siddle, Anne E. Willis, Brian Y.H. Lam, Martin Bushell, Susan E. Ozanne, Miguel Constância
Publikováno v:
Cell Reports, Vol 43, Iss 9, Pp 114750- (2024)
Summary: Mir483 is a conserved and highly expressed microRNA in placental mammals, embedded within the Igf2 gene. Its expression is dysregulated in a number of human diseases, including metabolic disorders and certain cancers. Here, we investigate th
Externí odkaz:
https://doaj.org/article/abbc32c9c19d41bf953422abe96dc435
Autor:
Mie Monti, Reyme Herman, Leonardo Mancini, Charlotte Capitanchik, Karen Davey, Charlotte S Dawson, Jernej Ule, Gavin H Thomas, Anne E Willis, Kathryn S Lilley, Eneko Villanueva
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 5, Pp 573-589 (2024)
Abstract Characterising RNA–protein interaction dynamics is fundamental to understand how bacteria respond to their environment. In this study, we have analysed the dynamics of 91% of the Escherichia coli expressed proteome and the RNA-interaction
Externí odkaz:
https://doaj.org/article/76a13b8e569f4c31bb10fc845610029f
Autor:
Yakinthi Chrisochoidou, Rajat Roy, Pooyeh Farahmand, Guadalupe Gonzalez, Jennifer Doig, Lukas Krasny, Ella F. Rimmer, Anne E Willis, Marion MacFarlane, Paul H. Huang, Neil O. Carragher, Alison F. Munro, Daniel J. Murphy, Kirill Veselkov, Michael J. Seckl, Miriam F. Moffatt, William O. C. Cookson, Olivier E. Pardo
Publikováno v:
Cell Death and Disease, Vol 14, Iss 11, Pp 1-20 (2023)
Abstract Mesothelioma is an aggressive cancer of the mesothelial layer associated with an extensive fibrotic response. The latter is in large part mediated by cancer-associated fibroblasts which mediate tumour progression and poor prognosis. However,
Externí odkaz:
https://doaj.org/article/aaf6d7ac3e1a4d1b86de96ee85ac0b92
Autor:
Juan Carlos Yam-Puc, Zhaleh Hosseini, Emily C. Horner, Pehuén Pereyra Gerber, Nonantzin Beristain-Covarrubias, Robert Hughes, Aleksei Lulla, Maria Rust, Rebecca Boston, Magda Ali, Katrin Fischer, Edward Simmons-Rosello, Martin O’Reilly, Harry Robson, Lucy H. Booth, Lakmini Kahanawita, Andrea Correa-Noguera, David Favara, Lourdes Ceron-Gutierrez, Baerbel Keller, Andrew Craxton, Georgina S. F. Anderson, Xiao-Ming Sun, Anne Elmer, Caroline Saunders, Areti Bermperi, Sherly Jose, Nathalie Kingston, Thomas E. Mulroney, Lucia P. G. Piñon, CITIID-NIHR COVID−19 BioResource Collaboration, Michael A. Chapman, Sofia Grigoriadou, Marion MacFarlane, Anne E. Willis, Kiran R. Patil, Sarah Spencer, Emily Staples, Klaus Warnatz, Matthew S. Buckland, Florian Hollfelder, Marko Hyvönen, Rainer Döffinger, Christine Parkinson, Sara Lear, Nicholas J. Matheson, James E. D. Thaventhiran
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Age-associated B cells (ABC) accumulate with age and in individuals with different immunological disorders, including cancer patients treated with immune checkpoint blockade and those with inborn errors of immunity. Here, we investigate whet
Externí odkaz:
https://doaj.org/article/6ba7520f8a864e5db48cb0eaab277223
Autor:
David P. O'Loughlin, Molly J. Haugen, Jason Day, Andrew S. Brown, Emma C. Braysher, Nick Molden, Anne E. Willis, Marion MacFarlane, Adam M. Boies
Publikováno v:
Environment International, Vol 178, Iss , Pp 108047- (2023)
The purpose of this study was to identify a characteristic elemental tyre fingerprint that can be utilised in atmospheric source apportionment calculations. Currently zinc is widely used as a single element tracer to quantify tyre wear, however sever
Externí odkaz:
https://doaj.org/article/cfc590f7c4984b26bf3cc05cd7f2c279
Autor:
Tobias von der Haar, Thomas E. Mulroney, Fabio Hedayioglu, Sathishkumar Kurusamy, Maria Rust, Kathryn S. Lilley, James E. Thaventhiran, Anne E. Willis, C. Mark Smales
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
In vitro transcribed, modified messenger RNAs (IVTmRNAs) have been used to vaccinate billions of individuals against the SARS-CoV-2 virus, and are currently being developed for many additional therapeutic applications. IVTmRNAs must be translated int
Externí odkaz:
https://doaj.org/article/a6fe20fc312948cb980fb2feac3e94c1
Publikováno v:
PLoS ONE, Vol 18, Iss 6, p e0286741 (2023)
Most of the small-molecule drugs approved for the treatment of cancer over the past 40 years are based on natural compounds. Bacteria provide an extensive reservoir for the development of further anti-cancer therapeutics to meet the challenges posed
Externí odkaz:
https://doaj.org/article/fdacae6b13064ec4936ff0bd3ed84753
Autor:
Anca Nastase, Amit Mandal, Shir Kiong Lu, Hima Anbunathan, Deborah Morris-Rosendahl, Yu Zhi Zhang, Xiao-Ming Sun, Spyridon Gennatas, Robert C. Rintoul, Matthew Edwards, Alex Bowman, Tatyana Chernova, Tim Benepal, Eric Lim, Anthony Newman Taylor, Andrew G. Nicholson, Sanjay Popat, Anne E. Willis, Marion MacFarlane, Mark Lathrop, Anne M. Bowcock, Miriam F. Moffatt, William O. C. M. Cookson
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Pleural mesothelioma is an aggressive malignancy with limited effective therapies. In order to identify therapeutic targets, we integrated SNP genotyping, sequencing and transcriptomics from tumours and low-passage patient-derived cells. Pre
Externí odkaz:
https://doaj.org/article/f4c03b22d13e4a60887cc31103bca100
Autor:
Stefano Grosso, Alberto Marini, Katarina Gyuraszova, Johan Vande Voorde, Aristeidis Sfakianos, Gavin D. Garland, Angela Rubio Tenor, Ryan Mordue, Tanya Chernova, Nobu Morone, Marco Sereno, Claire P. Smith, Leah Officer, Pooyeh Farahmand, Claire Rooney, David Sumpton, Madhumita Das, Ana Teodósio, Catherine Ficken, Maria Guerra Martin, Ruth V. Spriggs, Xiao-Ming Sun, Martin Bushell, Owen J. Sansom, Daniel Murphy, Marion MacFarlane, John P. C. Le Quesne, Anne E. Willis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Treating malignant pleural mesothelioma (MpM) is challenging due to a lack of druggable genes, but other molecular features could be clinically useful. Here the authors profile mRNA translation dysregulation in MpM cell lines using polysome profiling
Externí odkaz:
https://doaj.org/article/7e118ded480445418fbb52706c703037
Autor:
Pehuén Pereyra Gerber, Lidia M Duncan, Edward Jd Greenwood, Sara Marelli, Adi Naamati, Ana Teixeira-Silva, Thomas Wm Crozier, Ildar Gabaev, Jun R Zhan, Thomas E Mulroney, Emily C Horner, Rainer Doffinger, Anne E Willis, James Ed Thaventhiran, Anna V Protasio, Nicholas J Matheson
Publikováno v:
PLoS Pathogens, Vol 18, Iss 2, p e1010265 (2022)
Efforts to define serological correlates of protection against COVID-19 have been hampered by the lack of a simple, scalable, standardised assay for SARS-CoV-2 infection and antibody neutralisation. Plaque assays remain the gold standard, but are imp
Externí odkaz:
https://doaj.org/article/fc58511d567e4f39b8fc1cbccd1ce0b6