Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Anne E, Hagen"'
Autor:
Dennis Hyek, Jinshan Chen, R. Scott Obach, Melissa Wagenaar, Mark W. Bundesmann, Asser Bassyouni, Jeremy T. Starr, Maria S. Brown, Stephen Jenkinson, Manjinder S. Lall, Gregory Ciszewski, James Bradow, Gregory S. Walker, Senliang Pan, Douglas K. Spracklin, Bo Liu, Neal W. Sach, Daniel J Smaltz, Anne E. Hagen, Usa Reilly
Publikováno v:
Journal of Medicinal Chemistry. 63:7268-7292
An experimental approach is described for late-stage lead diversification of frontrunner drug candidates using nanomole-scale amounts of lead compounds for structure-activity relationship development. The process utilizes C-H bond activation methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a4f2cd830cd5ca3994e400969ad8fd2
https://doi.org/10.1021/acs.jmedchem.0c00483
https://doi.org/10.1021/acs.jmedchem.0c00483
Autor:
Manjinder S, Lall, Asser, Bassyouni, James, Bradow, Maria, Brown, Mark, Bundesmann, Jinshan, Chen, Gregory, Ciszewski, Anne E, Hagen, Dennis, Hyek, Stephen, Jenkinson, Bo, Liu, R Scott, Obach, Senliang, Pan, Usa, Reilly, Neal, Sach, Daniel J, Smaltz, Douglas K, Spracklin, Jeremy, Starr, Melissa, Wagenaar, Gregory S, Walker
Publikováno v:
Journal of medicinal chemistry. 63(13)
An experimental approach is described for late-stage lead diversification of frontrunner drug candidates using nanomole-scale amounts of lead compounds for structure-activity relationship development. The process utilizes C-H bond activation methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::64847a20d7e927f5644c919f79db1de5
https://pubmed.ncbi.nlm.nih.gov/32462865
https://pubmed.ncbi.nlm.nih.gov/32462865
Publikováno v:
Rapid Communications in Mass Spectrometry. 24:2109-2121
A simple procedure is described to identify acyl-glucuronides by coupled liquid chromatography/mass spectrometry after derivatization to a hydroxamic acid with hydroxylamine. The reaction specificity obviates the need for isolation of the acyl-glucur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab8cc3706a8408e4dd62d4bfffc6f921
https://doi.org/10.1002/rcm.4621
https://doi.org/10.1002/rcm.4621
Publikováno v:
Rapid communications in mass spectrometry : RCM. 24(14)
A simple procedure is described to identify acyl-glucuronides by coupled liquid chromatography/mass spectrometry after derivatization to a hydroxamic acid with hydroxylamine. The reaction specificity obviates the need for isolation of the acyl-glucur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::21fba3452f520166e9ee118607eb4409
https://pubmed.ncbi.nlm.nih.gov/20552710
https://pubmed.ncbi.nlm.nih.gov/20552710
Autor:
Mark Edward Flanagan, Anne E. Hagen, Yue Shen, Dennis Girard, Barbara J. Kamicker, Lou Chupak, Steven M. Finegan, Takushi Kaneko, Usa Reilly, Bryan Li, Timothy J. Strelevitz, R. Scott Obach, Richard A. Buzon, Gregory G. Stone, Karl Granskog, John Schafer, Joanna P. Wolkowski, Thuy-Trinh Nguyen, Mark C. Noe, Donn G. Wishka, Michael J. Falcone, John P. O'Donnell, Thomas J. Dougherty, David A. Whipple, Ivy Medina, Magee Thomas Victor, Joel R. Hardink, Jianmin Sun, Michael D. Huband, Jennifer L. Liras, Sharon L. Ripp, Kathleen A. Farley, Michael J. Knickerbocker, Andrea Marra, A. Tait-Kamradt, Joseph Penzien, Daniel W. Widlicka, Alfin D. N. Vaz
Publikováno v:
Journal of medicinal chemistry. 52(23)
Respiratory tract bacterial strains are becoming increasingly resistant to currently marketed macrolide antibiotics. The current alternative telithromycin (1) from the newer ketolide class of macrolides addresses resistance but is hampered by serious
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35f9468b29a17cd7d16cc76cd44d63f5
https://pubmed.ncbi.nlm.nih.gov/19775168
https://pubmed.ncbi.nlm.nih.gov/19775168
Autor:
Thomas V. Magee, Sharon L. Ripp, Bryan Li, Richard A. Buzon, Lou Chupak, Thomas J. Dougherty, Steven M. Finegan, Dennis Girard, Anne E. Hagen, Michael J. Falcone, Kathleen A. Farley, Karl Granskog, Joel R. Hardink, Michael D. Huband, Barbara J. Kamicker, Takushi Kaneko, Michael J. Knickerbocker, Jennifer L. Liras, Andrea Marra, Ivy Medina
Publikováno v:
Journal of Medicinal Chemistry; Dec2009, Vol. 52 Issue 23, p7446-7457, 12p