Stimulation of Slack K+ Channels Alters Mass at the Plasma Membrane by Triggering Dissociation of a Phosphatase-Regulatory Complex

Autor: Matthew R. Fleming, Maile R. Brown, Jack Kronengold, Yalan Zhang, David P. Jenkins, Gulia Barcia, Rima Nabbout, Anne E. Bausch, Peter Ruth, Robert Lukowski, Dhasakumar S. Navaratnam, Leonard K. Kaczmarek

Publikováno v: Cell Reports, Vol 16, Iss 9, Pp 2281-2288 (2016)

Human mutations in the cytoplasmic C-terminal domain of Slack sodium-activated potassium (KNa) channels result in childhood epilepsy with severe intellectual disability. Slack currents can be increased by pharmacological activators or by phosphorylat

Externí odkaz: https://doaj.org/article/2cfbf9c489e94d12aaac50269099564c

The Na+-activated K+ channel Slack contributes to synaptic development and plasticity

Autor: Felix Hoffmann, David Skrabak, Peter Ruth, Marius Ueffing, Thomas Pham, Rebekka Ehinger, Anne E. Bausch, Robert Lukowski, Philipp Eckert, Jiaqi Yin, Karsten Boldt, Lucas Matt, Miriam Gisevius

Publikováno v: Cellular and Molecular Life Sciences. 78:7569-7587

Human mutations of the Na+-activated K+ channel Slack (KCNT1) are associated with epilepsy and intellectual disability. Accordingly, Slack knockout mice (Slack−/−) exhibit cognitive flexibility deficits in distinct behavioral tasks. So far, howev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c64e96ee39ceda6fb80a084139a2cd8c
https://doi.org/10.1007/s00018-021-03953-0

Slack K

Autor: Rebekka, Ehinger, Anna, Kuret, Lucas, Matt, Nadine, Frank, Katharina, Wild, Clement, Kabagema-Bilan, Helmut, Bischof, Roland, Malli, Peter, Ruth, Anne E, Bausch, Robert, Lukowski

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 35(5)

The neuronal Na

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a5055eebacac4da60c6bca1fbb533b4b
https://pubmed.ncbi.nlm.nih.gov/33817875

Accessory heterozygous mutations in cone photoreceptor CNGA3 exacerbate CNG channel–associated retinopathy

Autor: Richard G. Weleber, Robert Lukowski, M. W. Seeliger, Christina Brennenstuhl, Anne E. Bausch, Xiangang Zong, Sascha Venturelli, John R. Heckenlively, Vithiyanjali Sothilingam, Stylianos Michalakis, Susanne C. Beck, Günther Rudolph, Naoyuki Tanimoto, Ulrich Kellner, Peggy Reuter, Anja K. Mayer, Ditta Zobor, Susanne Kohl, Bernd Wissinger, Gesa Astrid Hahn, Britta Baumann, Paul A. Sieving, Xi-Qin Ding, Nicole Weisschuh, Christian P. Hamel, Martin Biel, Robert K. Koenekoop, Peter Ruth, Peter Charbel Issa, Timm Krätzig, Gesine Huber, Elvir Becirovic, Markus Burkard, Katrin Junger

Publikováno v: The Journal of clinical investigation, vol 128, iss 12
Journal of Clinical Investigation
Journal of Clinical Investigation, American Society for Clinical Investigation, 2018, 128 (12), pp.5663--5675. ⟨10.1172/JCI96098⟩

International audience; Mutations in CNGA3 and CNGB3, the genes encoding the subunits of the tetrameric cone photoreceptor cyclic nucleotide–gated ion channel, cause achromatopsia, a congenital retinal disorder characterized by loss of cone functio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::470e7ba4f9a01dd349b61665c4c93838
https://doi.org/10.1172/jci96098

Loss of Sodium-Activated Potassium Channel Slack and FMRP Differentially Affect Social Behavior in Mice

Autor: Rebekka Ehinger, Patrick Zerfass, Anne E. Bausch, Julia Straubinger, Yvette Nann, Robert Lukowski

Publikováno v: Neuroscience. 384

The sodium-activated potassium channel Slack (Slo2.2) is widely expressed in central and peripheral neurons where it is supposed to shape firing properties important for neuronal excitability. Slack activity is enhanced by interaction with the Fragil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed7be3ef7a9e416ba4517116cdb14514
https://pubmed.ncbi.nlm.nih.gov/29859980