Výsledky vyhledávání - "Anne Dekeyne"

Akademický článek

5‐HT6 receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia

Autor: Julie Meffre, Séverine Chaumont‐Dubel, Clotilde Mannoury la Cour, Florence Loiseau, David J. G. Watson, Anne Dekeyne, Martial Séveno, Jean‐Michel Rivet, Florence Gaven, Paul Déléris, Denis Hervé, Kevin C. F. Fone, Joël Bockaert, Mark J. Millan, Philippe Marin

Publikováno v: EMBO Molecular Medicine, Vol 4, Iss 10, Pp 1043-1056 (2012)

Abstract Cognitive deficits in schizophrenia severely compromise quality of life and are poorly controlled by current antipsychotics. While 5‐HT6 receptor blockade holds special promise, molecular substrates underlying their control of cognition re

Externí odkaz: https://doaj.org/article/a0066cfd997d434495adbb9a5a7bd59e

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Comparative Pro-cognitive and Neurochemical Profiles of Glycine Modulatory Site Agonists and Glycine Reuptake Inhibitors in the Rat: Potential Relevance to Cognitive Dysfunction and Its Management

Autor: Millan Mark, Kevin C. F. Fone, Rodolphe Billiras, Alain P. Gobert, Anne Dekeyne, Jean-Michel Rivet, Dorothée Sicard, David J. G. Watson

Publikováno v: Molecular Neurobiology

Frontocortical NMDA receptors are pivotal in regulating cognition and mood, are hypofunctional in schizophrenia, and may contribute to autistic spectrum disorders. Despite extensive interest in agents potentiating activity at the co-agonist glycine m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f74883ba07eb7cf22df51091a6c81478
https://pubmed.ncbi.nlm.nih.gov/31960362

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Dual-acting agents for improving cognition and real-world function in Alzheimer’s disease: Focus on 5-HT6 and D3 receptors as hubs

Autor: David M. Watson, Mauricette Brocco, Kevin C. F. Fone, Anne Dekeyne, Clotilde Mannoury la Cour, Jean-Claude Ortuno, Millan Mark, Alain P. Gobert

Publikováno v: Neuropharmacology. 177:108099

© 2020 Elsevier Ltd To date, there are no interventions that impede the inexorable progression of Alzheimer's disease (AD), and currently-available drugs cholinesterase (AChE) inhibitors and the N-Methyl-D-Aspartate receptor antagonist, memantine, o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1af770005d941744e5545396b4dd1763
https://doi.org/10.1016/j.neuropharm.2020.108099

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S32006, a novel 5-HT2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models

Autor: Amélie Soumier, Trevor Sharp, Mariusz Papp, Mauricette Brocco, Gunnar Flik, Jean-Michel Rivet, Anne Dekeyne, Françoise Lejeune, Thomas I. F. H. Cremers, Alain Gobert, Florence Serres, Millan Mark, Annie Daszuta, Olivier Muller, Clotilde Mannoury la Cour, Gilbert Lavielle

Publikováno v: Psychopharmacology (Berl)
Psychopharmacology (Berl), 2008, 199 (4), pp.549-68

RATIONALE: Serotonin (5-HT)(2C) receptors are implicated in the control of mood, and their blockade is of potential interest for the management of anxiodepressive states. OBJECTIVES: Herein, we characterized the in vitro and in vivo pharmacological p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b939857ddaecc03e4bac8547193eef2
https://ora.ox.ac.uk/objects/uuid:bf9f3d5a-5050-4674-be0f-6a9c9f69b4b2

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5‐HT 6 receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia

Autor: Joël Bockaert, Jean-Michel Rivet, Anne Dekeyne, Julie Meffre, Clotilde Mannoury la Cour, Philippe Marin, David J. G. Watson, Paul Déléris, Denis Hervé, Kevin C. F. Fone, Millan Mark, Florence Loiseau, Martial Séveno, Florence Gaven, Séverine Chaumont-Dubel

Publikováno v: EMBO Molecular Medicine

Cognitive deficits in schizophrenia severely compromise quality of life and are poorly controlled by current antipsychotics. While 5-HT(6) receptor blockade holds special promise, molecular substrates underlying their control of cognition remain uncl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609ae7011f3aad06ae2d1af053444def
https://doi.org/10.1002/emmm.201201410

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S41744, a dual neurokinin (NK)1 receptor antagonist and serotonin (5-HT) reuptake inhibitor with potential antidepressant properties: A comparison to aprepitant (MK869) and paroxetine

Autor: Gunnar Flik, Trynke R. de Jong, Millan Mark, Guillaume de Nanteuil, Anne Dekeyne, Clotilde Mannoury la Cour, Berend Olivier, Françoise Lejeune, Thomas I. F. H. Cremers, Mauricette Brocco, Jean-Michel Rivet, Alain Gobert, Benjamin Di Cara

Publikováno v: European Neuropsychopharmacology. 20:599-621

Though neurokinin(1) (NK(1)) receptors are implicated in depressed states and their treatment, selective antagonists have disappointed in clinical trials. Accordingly, we designed a novel ligand, S41744 (2-piperazin-1-yl-indan-2-carboxylic-acid-(3-ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eea0ece5c5e6d40a00b6660c3fa215b7
https://doi.org/10.1016/j.euroneuro.2010.04.003

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Neurokinin1 Antagonists Potentiate Antidepressant Properties of Serotonin Reuptake Inhibitors, Yet Blunt Their Anxiogenic Actions: A Neurochemical, Electrophysiological, and Behavioral Characterization

Autor: Gaëlle Bouchez, Benjamin Di Cara, Robert L. Gannon, Anne Dekeyne, Mauricette Brocco, Millan Mark, Françoise Lejeune, Alain P. Gobert

Publikováno v: Neuropsychopharmacology. 34:1039-1056

Though neurokinin(1) (NK(1)) receptor antagonists are active in experimental models of depression, clinical efficacy has proven disappointing. This encourages interest in association of NK(1) receptor blockade with inhibition of serotonin (5-HT) reup

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed50d208064b436e20187c545b7fd8d9
https://doi.org/10.1038/npp.2008.176

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Cellular and behavioural profile of the novel, selective neurokinin1 receptor antagonist, vestipitant: A comparison to other agents

Autor: Clotilde Mannoury la Cour, Manuelle Touzard, Trynke R. deJong, Mauricette Brocco, Sylvie Girardon, Anne Dekeyne, Guillaume de Nanteuil, Millan Mark, Sylvie Veiga, Berend Olivier

Publikováno v: European Neuropsychopharmacology. 18:729-750

This study characterized the novel neurokinin (NK)(1) antagonist, vestipitant, under clinical evaluation for treatment of anxiety and depression. Vestipitant possessed high affinity for human NK(1) receptors (pK(i), 9.4), and potently blocked Substan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d91a2a01dec513d4b432eee13e1fca6c
https://doi.org/10.1016/j.euroneuro.2008.06.002

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S33138 (N-[4-[2-[(3aS,9bR)-8-cyano-1,3a,4,9b-tetrahydro[1] benzopyrano[3,4-c]pyrrol-2(3H)-yl)-ethyl]phenyl-acetamide), a Preferential Dopamine D3 versus D2 Receptor Antagonist and Potential Antipsychotic Agent: III. Actions in Models of Therapeutic Activity and Induction of Side Effects

Autor: Rodolphe Billiras, Thomas I. F. H. Cremers, Mauricette Brocco, Jean-Michel Rivet, Gunnar Flik, Florence Loiseau, Anne Dekeyne, Dorothée Sicard, Millan Mark, Alain P. Gobert

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 324:1212-1226

In contrast to clinically available antipsychotics, the novel benzopyranopyrrolidine derivative, S33138 (N-[4-[2-[(3aS,9bR)-8-cyano-1,3a,4,9b-tetrahydro[1]benzopyrano[3,4-c]pyrrol-2(3H)-yl)-ethyl]phenyl-acetamide), behaves as a preferential antagonis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::26841ebe93f945f6e3e570783e38fbc1
https://doi.org/10.1124/jpet.107.134536

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