Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Anne Danks"'
Autor:
Yingzhuo Yan, Guibao Gu, J. A. Vivian, Adia Zhang, Ali Tabatabaei, Laurent Gomez, Yu-wen Li, J. Guy Breitenbucher, Kathleen Aertgeerts, Hao Xu, Anne Danks, Eben Massari, Andrew Morse, Noelle Warren, Trevor Scott
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 370:399-407
Inhibition of phosphodiesterase 2A (PDE2A) has been proposed as a potential approach to enhance cognitive functioning and memory through boosting intracellular cGMP/cAMP and enhancing neuroplasticity in memory-related neural circuitry. Previous precl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d03790391b33c5e0ffef95d90958cef0
https://doi.org/10.1124/jpet.118.255851
https://doi.org/10.1124/jpet.118.255851
Autor:
Kiev S. Ly, Andrew Richard Hudson, Christine Hoffmaster, James T. Limberis, J. Guy Breitenbucher, Richard Barido, De Michael Chung, Yingzhuo Yan, Gary Anderson, Vincent J. Santora, Dany Gitnick, Dong Lee, Brett C. Bookser, Anne Danks, Robert E. Petroski, Graeme Freestone, Varsha Gupta, Clifford Cabebe, Andrew Morse, Michael R. Kennedy, Kristen Sebring, Zachary W. Yoder, Douglas Zook, Marco Peters, Chih-Kun Chai, Joel Renick, Jim Na, Theresa A. Almos, Shouzhen Xia, Ali Tabatabaei, John Nikpur, Samantha Sevidal, Stephine Chow, Mi Chen, Jillian Basinger, Chris L. Bellows, Lindsay Heger, David Neul, Jenny Wen, Brittany Masatsugu, Nicola J. Broadbent, Alan P. Kaplan, Chi Ching Mak
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(14)
A strategy to conformationally restrain a series of GlyT1 inhibitors identified potent analogs that exhibited slowly interconverting rotational isomers. Further studies to address this concern led to a series of azetidine-based inhibitors. Compound 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912579fcc2f963bd82182bdd275301b0
https://pubmed.ncbi.nlm.nih.gov/32527538
https://pubmed.ncbi.nlm.nih.gov/32527538
Autor:
David Neul, Andrew Morse, Joel Renick, Brittany Masatsugu, Chi Ching Mak, James T. Limberis, Dany Gitnick, Zachary W. Yoder, Michael R. Kennedy, Kiev S. Ly, Samantha Sevidal, Richard Barido, Robert E. Petroski, Graeme Freestone, Clifford Cabebe, Jillian Basinger, Vincent J. Santora, Christine Hoffmaster, Chris L. Bellows, Yingzhuo Yan, Mi Chen, De Michael Chung, John Nikpur, Kristen Sebring, Jenny Wen, Ali Tabatabaei, Brett C. Bookser, Theresa A. Almos, Andrew Richard Hudson, J. Guy Breitenbucher, Chih-Kun Chai, Dong Lee, Lindsay Crickard, Anne Danks, Varsha Gupta, Marco Peters, Alan P. Kaplan, Jim Na, Nicola J. Broadbent, Stephine Chow, Douglas Zook
Publikováno v:
Journal of Medicinal Chemistry. 61:6018-6033
We report here the identification and optimization of a novel series of potent GlyT1 inhibitors. A ligand design campaign that utilized known GlyT1 inhibitors as starting points led to the identification of a novel series of pyrrolo[3,4- c]pyrazoles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3769bd94e72c5343ca6a4bb3a9739f64
https://doi.org/10.1021/acs.jmedchem.8b00372
https://doi.org/10.1021/acs.jmedchem.8b00372
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 146:361-368
A robust high-performance liquid chromatography tandem mass spectrometry (LC-MS/MS) assay was developed and qualified for the measurement of cyclic nucleotides (cNTs) in rat brain tissue. Stable isotopically labeled 3',5'-cyclic adenosine-13C5 monoph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32f3024df10682fb4ec61166c5471afe
https://doi.org/10.1016/j.jpba.2017.08.040
https://doi.org/10.1016/j.jpba.2017.08.040
Autor:
Lindsay Crickard, Guibao Gu, Kathe Stauber, Michael Chung, Doug Zook, Trevor Scott, Ali Tabatabaei, Jie Chen, Jef Vivian, Jenny Chen, Vinny Santora, Anne Danks, Yu-wen Li
Publikováno v:
Drug Metabolism and Pharmacokinetics. 34:S67
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb91914f5113ad5b7437fb897cf0d716
https://doi.org/10.1016/j.dmpk.2018.09.230
https://doi.org/10.1016/j.dmpk.2018.09.230
Publikováno v:
Drug Metabolism and Pharmacokinetics. 33:S37
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c92acfeb8b774dd136336236c8af9fa
https://doi.org/10.1016/j.dmpk.2017.11.134
https://doi.org/10.1016/j.dmpk.2017.11.134