3-Weeks of Exercise Training Increases Ischemic-Tolerance in Hearts From High-Fat Diet Fed Mice

Autor: Neoma T. Boardman, Line Rossvoll, Jim Lund, Anne D. Hafstad, Ellen Aasum

Publikováno v: Frontiers in Physiology, Vol 10 (2019)

Physical activity is an efficient strategy to delay development of obesity and insulin resistance, and thus the progression of obesity/diabetes-related cardiomyopathy. In support of this, experimental studies using animal models of obesity show that

Externí odkaz: https://doaj.org/article/72232bbd2e954c75a757159cbd9fcfeb

Myocardial NADPH oxidase-4 regulates the physiological response to acute exercise

Autor: Matthew Hancock, Anne D Hafstad, Adam A Nabeebaccus, Norman Catibog, Angela Logan, Ioannis Smyrnias, Synne S Hansen, Johanna Lanner, Katrin Schröder, Michael P Murphy, Ajay M Shah, Min Zhang

Publikováno v: eLife, Vol 7 (2018)

Regular exercise has widespread health benefits. Fundamental to these beneficial effects is the ability of the heart to intermittently and substantially increase its performance without incurring damage, but the underlying homeostatic mechanisms are

Externí odkaz: https://doaj.org/article/d60ddf91fb1e44da9f85f227b2832b85

Nox4 regulates InsP3 receptor‐dependent Ca2+ release into mitochondria to promote cell survival

Autor: Matteo Beretta, Tsung-Ping Su, Aram Revazian, Katrin Streckfuß-Bömeke, Kai B. Betteridge, Maddy Parsons, Christopher C.J. Miller, Katrin Schröder, Vsevolod V. Belousov, Ajay M. Shah, Roland A. Fleck, Chris Molenaar, Anne D. Hafstad, Celio Xc. Santos, James H. Doroshow

Publikováno v: Beretta, M, Santos, C X, Molenaar, C, Hafstad, A D, Miller, C C, Revazian, A, Betteridge, K, Schröder, K, Streckfuß-Bömeke, K, Doroshow, J H, Fleck, R A, Su, T-P, Belousov, V V, Parsons, M & Shah, A M 2020, ' Nox4 regulates InsP3 receptor-dependent Ca2+ release into mitochondria to promote cell survival ', The EMBO journal, vol. 39, no. 19, e103530 . https://doi.org/10.15252/embj.2019103530, https://doi.org/10.15252/embj.2019103530

Cells subjected to environmental stresses undergo regulated cell death (RCD) when homeostatic programs fail to maintain viability. A major mechanism of RCD is the excessive calcium loading of mitochondria and consequent triggering of the mitochondria

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2428414e153146144d20d3bed459da8f
https://kclpure.kcl.ac.uk/en/publications/b1dadedb-a236-4e62-98b9-f52f75dffab6

NADPH oxidase 2 mediates myocardial oxygen wasting in obesity

Autor: Jim Lund, Ajay M. Shah, Celio X.C. Santos, Synne Simonsen Hansen, Anne D. Hafstad, Neoma T. Boardman, Ellen Aasum

Publikováno v: Antioxidants
Volume 9
Issue 2
Antioxidants, Vol 9, Iss 2, p 171 (2020)

Obesity and diabetes are independent risk factors for cardiovascular diseases, and they are associated with the development of a specific cardiomyopathy with elevated myocardial oxygen consumption (MVO2) and impaired cardiac efficiency. Although the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f18188559e5352107c47c28001b01fd6
https://hdl.handle.net/10037/20596

Nox4 regulates InsP

Autor: Matteo, Beretta, Celio Xc, Santos, Chris, Molenaar, Anne D, Hafstad, Chris Cj, Miller, Aram, Revazian, Kai, Betteridge, Katrin, Schröder, Katrin, Streckfuß-Bömeke, James H, Doroshow, Roland A, Fleck, Tsung-Ping, Su, Vsevolod V, Belousov, Maddy, Parsons, Ajay M, Shah

Publikováno v: The EMBO journal. 39(19)

Cells subjected to environmental stresses undergo regulated cell death (RCD) when homeostatic programs fail to maintain viability. A major mechanism of RCD is the excessive calcium loading of mitochondria and consequent triggering of the mitochondria

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f7fffd4f76ca9cd7ba686fbfa7511d0f
https://pubmed.ncbi.nlm.nih.gov/33581406