Overexpression of NOX2 Exacerbates AngII-Mediated Cardiac Dysfunction and Metabolic Remodelling

Autor: Synne S. Hansen, Tina M. Pedersen, Julie Marin, Neoma T. Boardman, Ajay M. Shah, Ellen Aasum, Anne D. Hafstad

Publikováno v: Antioxidants, Vol 11, Iss 1, p 143 (2022)

The present study aimed to examine the effects of low doses of angiotensin II (AngII) on cardiac function, myocardial substrate utilization, energetics, and mitochondrial function in C57Bl/6J mice and in a transgenic mouse model with cardiomyocyte sp

Externí odkaz: https://doaj.org/article/a8cc8b62aa584c88b7bb9c53c348cdab

Myocardial NADPH oxidase-4 regulates the physiological response to acute exercise

Autor: Matthew Hancock, Anne D Hafstad, Adam A Nabeebaccus, Norman Catibog, Angela Logan, Ioannis Smyrnias, Synne S Hansen, Johanna Lanner, Katrin Schröder, Michael P Murphy, Ajay M Shah, Min Zhang

Publikováno v: eLife, Vol 7 (2018)

Regular exercise has widespread health benefits. Fundamental to these beneficial effects is the ability of the heart to intermittently and substantially increase its performance without incurring damage, but the underlying homeostatic mechanisms are

Externí odkaz: https://doaj.org/article/d60ddf91fb1e44da9f85f227b2832b85

NADPH Oxidase 2 Mediates Myocardial Oxygen Wasting in Obesity

Autor: Anne D. Hafstad, Synne S. Hansen, Jim Lund, Celio X. C. Santos, Neoma T. Boardman, Ajay M. Shah, Ellen Aasum

Publikováno v: Antioxidants, Vol 9, Iss 2, p 171 (2020)

Obesity and diabetes are independent risk factors for cardiovascular diseases, and they are associated with the development of a specific cardiomyopathy with elevated myocardial oxygen consumption (MVO2) and impaired cardiac efficiency. Although the

Externí odkaz: https://doaj.org/article/1fb90a1ebc844e6baaf60edeff69b121

Nox4 regulates InsP3 receptor‐dependent Ca2+ release into mitochondria to promote cell survival

Autor: Matteo Beretta, Tsung-Ping Su, Aram Revazian, Katrin Streckfuß-Bömeke, Kai B. Betteridge, Maddy Parsons, Christopher C.J. Miller, Katrin Schröder, Vsevolod V. Belousov, Ajay M. Shah, Roland A. Fleck, Chris Molenaar, Anne D. Hafstad, Celio Xc. Santos, James H. Doroshow

Publikováno v: Beretta, M, Santos, C X, Molenaar, C, Hafstad, A D, Miller, C C, Revazian, A, Betteridge, K, Schröder, K, Streckfuß-Bömeke, K, Doroshow, J H, Fleck, R A, Su, T-P, Belousov, V V, Parsons, M & Shah, A M 2020, ' Nox4 regulates InsP3 receptor-dependent Ca2+ release into mitochondria to promote cell survival ', The EMBO journal, vol. 39, no. 19, e103530 . https://doi.org/10.15252/embj.2019103530, https://doi.org/10.15252/embj.2019103530

Cells subjected to environmental stresses undergo regulated cell death (RCD) when homeostatic programs fail to maintain viability. A major mechanism of RCD is the excessive calcium loading of mitochondria and consequent triggering of the mitochondria

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2428414e153146144d20d3bed459da8f
https://kclpure.kcl.ac.uk/en/publications/b1dadedb-a236-4e62-98b9-f52f75dffab6

NADPH oxidase 2 mediates myocardial oxygen wasting in obesity

Autor: Jim Lund, Ajay M. Shah, Celio X.C. Santos, Synne Simonsen Hansen, Anne D. Hafstad, Neoma T. Boardman, Ellen Aasum

Publikováno v: Antioxidants
Volume 9
Issue 2
Antioxidants, Vol 9, Iss 2, p 171 (2020)

Obesity and diabetes are independent risk factors for cardiovascular diseases, and they are associated with the development of a specific cardiomyopathy with elevated myocardial oxygen consumption (MVO2) and impaired cardiac efficiency. Although the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f18188559e5352107c47c28001b01fd6
https://hdl.handle.net/10037/20596