The role of T‐type calcium channels in elderly human vascular function: A pilot randomized controlled trial

Autor: Ulrik Winning Iepsen, Andreas R. Hjortdal, Anne D. Thuesen, Stine H. Finsen, Pernille B. L. Hansen, Stefan P. Mortensen

Publikováno v: Experimental Physiology, Vol 109, Iss 5, Pp 779-790 (2024)

Abstract Endothelial dysfunction develops with age and may precede cardiovascular disease. Animal data suggest that T‐type calcium channels play an important role in endothelial function, but data from humans are lacking. This study included 15 hea

Externí odkaz: https://doaj.org/article/870e04f7bb914426afc02258afe07bc7

Albuminuria is associated with an increased prostasin in urine while aldosterone has no direct effect on urine and kidney tissue abundance of prostasin

Autor: Birgül Kurt, Mette Staehr, Pernille B. Lærkegaard Hansen, Gitte R. Hinrichs, Claus Bistrup, Boye L. Jensen, Christina Stolzenburg Oxlund, Per Svenningsen, Mie R. Hansen, Ilona Schwarzensteiner, Ib Abildgaard Jacobsen, Anja Toft, Anne D Thuesen

Publikováno v: Stolzenburg Oxlund, C, Kurt, B, Schwarzensteiner, I, Hansen, M R, Stæhr, M, Svenningsen, P, Jacobsen, I A, Hansen, P B, Thuesen, A D, Toft, A, Hinrichs, G R, Bistrup, C & Jensen, B L 2017, ' Albuminuria is associated with an increased prostasin in urine while aldosterone has no direct effect on urine and kidney tissue abundance of prostasin ', Pfluegers Archiv, vol. 469, no. 5-6, pp. 655–667 . https://doi.org/10.1007/s00424-017-1938-6

The proteinase prostasin is a candidate mediator for aldosterone-driven proteolytic activation of the epithelial sodium channel (ENaC). It was hypothesized that the aldosterone-mineralocorticoid receptor (MR) pathway stimulates prostasin abundance in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6235fd863d3e55514ccd4f982e378325
https://doi.org/10.1007/s00424-017-1938-6

Deficiency of T-type Ca

Autor: Anne D, Thuesen, Stine H, Finsen, Louise L, Rasmussen, Ditte C, Andersen, Boye L, Jensen, Pernille B L, Hansen

Publikováno v: American journal of physiology. Renal physiology. 317(2)

T-type Ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::03cbd495337dd84e422a342bb9d9c7ff
https://pubmed.ncbi.nlm.nih.gov/31042060

Differential effect of T-type voltage-gated Ca2+ channel disruption on renal plasma flow and glomerular filtration rate in vivo

Autor: Pernille Lund Hansen, Anne D Thuesen, Majken Cardel, Henrik J. Andersen, Anja Toft, Peter Bie, Boye L. Jensen, Niels Marcussen, Walter S

Publikováno v: Thuesen, A D, Andersen, H, Cardel, M, Toft, A, Walter, S, Marcussen, N, Jensen, B L, Bie, P & Hansen, P B L 2014, ' Differential effect of T-type voltage-gated Ca 2+ channel disruption on renal plasma flow and glomerular filtration rate in vivo ', American Journal of Physiology: Renal Physiology, vol. 307, no. 4, pp. F445-F452 . https://doi.org/10.1152/ajprenal.00016.2014

Voltage-gated Ca2+ (Cav) channels play an essential role in the regulation of renal blood flow and glomerular filtration rate (GFR). Because T-type Cav channels are differentially expressed in pre- and postglomerular vessels, it was hypothesized that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaaad1afbc2d7caf5eab973374e0be56
https://doi.org/10.1152/ajprenal.00016.2014

P/Q-type and T-type voltage-gated calcium channels are involved in the contraction of mammary and brain blood vessels from hypertensive patients

Autor: Ole Skøtt, Frantz Rom Poulsen, Jane Stubbe, Anne D Thuesen, Lotte Rasmussen, Kristina S. Lyngsø, Lars Melholt Rasmussen, Pernille B. Lærkegaard Hansen, Christian Bonde Pedersen

Publikováno v: Thuesen, A D, Lyngsø, K S, Rasmussen, L, Stubbe, J, Skøtt, O, Rom Poulsen, F, Pedersen, C B, Rasmussen, L M & Hansen, P B L 2017, ' P/Q-type and T-type voltage-gated calcium channels are involved in the contraction of mammary and brain blood vessels from hypertensive patients ', Acta Physiologica, vol. 219, no. 3, pp. 642–653 . https://doi.org/10.1111/apha.12732

AIM: Calcium channel blockers are widely used in cardiovascular diseases. Besides L-type channels, T- and P/Q-type calcium channels are involved in the contraction of human renal blood vessels. It was hypothesized that T- and P/Q-type channels are in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4985cd90192094a1651d020aa64173f6
https://pubmed.ncbi.nlm.nih.gov/27273014