Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Anne Colombero"'
Autor:
Kevin Gaida, Xuxia Zhang, Robin Elliott, Benxian Liu, Andrea Itano, Cynthia Park, Justin K. Murray, Colin V. Gegg, Jennifer Aral, Les P. Miranda, Joseph G. McGivern, Hongyan Li, Anne Colombero, E. Allen Sickmier, Kevin Salyers, Michael Stenkilsson, Jonathan Werner, Steven Yu, Mark J. Rose, John K. Sullivan, Yi-Xin Qian, Peter Miu, Kristin L. Andrews
Publikováno v:
Journal of Medicinal Chemistry. 58:6784-6802
To realize the medicinal potential of peptide toxins, naturally occurring disulfide-rich peptides, as ion channel antagonists, more efficient pharmaceutical optimization technologies must be developed. Here, we show that the therapeutic properties of
Autor:
Irina Solovyev, John M. Delaney, Sanjay D. Khare, Shi-Yuan Meng, Anne Colombero, James J. S. Treanor, Susan McCabe, Robin Elliott, William J. Boyle, Gang Yu, Xing-Zhong Xia, Michael J. Kelley, Giorgio Senaldi, Judy Wang, Kent Miner, Frances Lee, Nessa Hawkins, Marina Stolina, Jane Guo, Lars Eyde Theill, Hailing Hsu, Tom Boone
Publikováno v:
The Journal of Experimental Medicine
We and others recently reported tumor necrosis factor (TNF) and apoptosis ligand–related leukocyte-expressed ligand 1 (TALL-1) as a novel member of the TNF ligand family that is functionally involved in B cell proliferation. Transgenic mice overexp
Autor:
Hailing Hsu, Gary Elliott, Michael Bass, Ildiko Sarosi, Emma Timms, Ling Wang, Michael J. Kelley, Casey Capparelli, David L. Lacey, Robin Elliott, Sheila Scully, Laura Chiu, Xing-Zhong Xia, Hong-Lin Tan, Grant Shimamoto, Irina Solovyev, Sean Morony, William J. Boyle, Anne Colombero, Colin R. Dunstan, Tabitha Black
Publikováno v:
Proceedings of the National Academy of Sciences. 96:3540-3545
A receptor that mediates osteoprotegerin ligand (OPGL)-induced osteoclast differentiation and activation has been identified via genomic analysis of a primary osteoclast precursor cell cDNA library and is identical to the tumor necrosis factor recept
Autor:
Nessa Hawkins, Anne Colombero, Colin R. Dunstan, John M. Delaney, Steve Kaufman, Tim Burgess, S. Scully, E. Davy, Victoria Shalhoub, Robin Elliott, Giorgio Senaldi, Hailing Hsu, Jane Guo, John K. Sullivan, Hong-Lin Tan, Gary Elliott, Michael J. Kelley, Ildiko Sarosi, William J. Boyle, C. Capparelli, Emma Timms, David L. Lacey, Alana Eli, Yi-xin Qian
Publikováno v:
Cell. 93:165-176
The ligand for osteoprotegerin has been identified, and it is a TNF-related cytokine that replaces the requirement for stromal cells, vitamin D3, and glucocorticoids in the coculture model of in vitro osteoclastogenesis. OPG ligand (OPGL) binds to a
Autor:
William J. Boyle, Michael J. Kelley, Anne Colombero, Hailing Hsu, Robin Elliott, Irina Solovyev
Publikováno v:
Journal of Biological Chemistry. 272:13471-13474
Members of tumor necrosis factor receptor (TNFR) family signal largely through interactions with death domain proteins and TRAF proteins. Here we report the identification of a novel TNFR family member ATAR. Human and mouse ATAR contain 283 and 276 a
Autor:
Richard A. Lindberg, Gary M. Fox, Robin Elliott, Ming Zhang, Vann P. Parker, Brian Varnum, Anne Colombero, James D. Skrine, Yosef Yarden, Geraldine Trail, William J. Boyle, Tony Hunter, Timothy D. Bartley, Robert J. Toso, Andrew A. Welcher, Paige Holst, Elsa Fernandez, Brenda Guthrie, Robert W. Hunt, Hsieng Sen Lu
Publikováno v:
Nature. 368(6471)
A protein ligand for the ECK receptor protein-tyrosine kinase has been isolated by using the extracellular domain (ECK-X) of the receptor as an affinity reagent. Initially, concentrated cell culture supernatants were screened for receptor binding act
Autor:
Hung Q. Nguyen, P Derby, Anne Colombero, Michael J. Kelley, N. Bucay, Dave Hill, L Renshaw-Gegg, William J. Boyle, Grant Shimamoto, W Pattison, S Sander, Colin R. Dunstan, R Lüthy, Patricia Shehan Campbell, David L. Lacey, William S. Simonet, John K. Sullivan, T.M Hughes, Geraldine Trail, Ming-Shi Chang, Margaret L. DeRose, S Wooden, Gwyneth Van, L Bennett, John E. Tarpley, Richard Lee, Robin Elliott, E. Davy, Tom Boone, Hong-Lin Tan
Publikováno v:
Scopus-Elsevier
A novel secreted glycoprotein that regulates bone resorption has been identified. The protein, termed Osteoprotegerin (OPG), is a novel member of the TNF receptor superfamily. In vivo, hepatic expression of OPG in transgenic mice results in a profoun