Data from Regulatory T Cells Recruited through CCL22/CCR4 Are Selectively Activated in Lymphoid Infiltrates Surrounding Primary Breast Tumors and Lead to an Adverse Clinical Outcome

Autor: Christine Ménétrier-Caux, Jean-Yves Blay, Christophe Caux, Alain Puisieux, Isabelle Ray-Coquard, Christelle Faure, Nicolas Pasqual, Solène Perez, Daniel Olive, Isabelle Durand, Anne Claire Doffin, Cathy Biota, Vanessa Arfi, Sophie Goddard-Leon, Thomas Bachelot, Nathalie Bendriss-Vermare, Isabelle Treilleux, Michael Gobert

Immunohistochemical analysis of FOXP3 in primary breast tumors showed that a high number of tumor-infiltrating regulatory T cells (Ti-Treg) within lymphoid infiltrates surrounding the tumor was predictive of relapse and death, in contrast to those pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::75a81c0bb131fd9b0fe62eb2076f37b0
https://doi.org/10.1158/0008-5472.c.6499602.v1

Guidelines for visualization and analysis of DC in tissues using multiparameter fluorescence microscopy imaging methods

Autor: Felix Bayerl, David A. Bejarano, Giulia Bertacchi, Anne‐Claire Doffin, Elisa Gobbini, Margaux Hubert, Lijian Li, Philippa Meiser, Anna‐Marie Pedde, Wilfried Posch, Luise Rupp, Andreas Schlitzer, Marc Schmitz, Barbara U. Schraml, Stefan Uderhardt, Jenny Valladeau‐Guilemond, Doris Wilflingseder, Viktoria Zaderer, Jan P. Böttcher

Publikováno v: European Journal of Immunology. :2249923

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb3fe9c57a12ed709792931d9be85eb1
https://doi.org/10.1002/eji.202249923

IFN-III is selectively produced by cDC1 and predicts good clinical outcome in breast cancer

Autor: Jenny Valladeau-Guilemond, Elisa Gobbini, Christophe Sajous, Vincent Ollion, Céline Rodriguez, Olivier Tredan, Margaux Hubert, Isabelle Treilleux, Marc Dalod, Justine Berthet, Bertrand Dubois, Christophe Caux, Janice Kielbassa, Coline Couillault, Anne-Claire Doffin, Thien-Phong Vu Manh, Nathalie Bendriss-Vermare

Publikováno v: Science Immunology
Science Immunology, American Association for the Advancement of Science, 2020, 5 (46), pp.eaav3942. ⟨10.1126/sciimmunol.aav3942⟩
Science Immunology, 2020, 5 (46), pp.eaav3942. ⟨10.1126/sciimmunol.aav3942⟩

International audience; Dendritic cells play a key role in the orchestration of antitumor immune responses. The cDC1 (conventional dendritic cell 1) subset has been shown to be essential for antitumor responses and response to immunotherapy, but its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c2eb7aae4413f6ef5a8f8c0a44d3c42
https://pubmed.ncbi.nlm.nih.gov/32303573

Regulatory T Cells Recruited through CCL22/CCR4 Are Selectively Activated in Lymphoid Infiltrates Surrounding Primary Breast Tumors and Lead to an Adverse Clinical Outcome

Autor: Solène Perez, Sophie Goddard-Léon, Vanessa Arfi, Anne Claire Doffin, Daniel Olive, Isabelle Treilleux, Christelle Faure, Alain Puisieux, Jean-Yves Blay, Isabelle Ray-Coquard, Nathalie Bendriss-Vermare, Christophe Caux, Nicolas Pasqual, Thomas Bachelot, Isabelle Durand, Christine Ménétrier-Caux, Cathy Biota, Michael Gobert

Publikováno v: Cancer Research. 69:2000-2009

Immunohistochemical analysis of FOXP3 in primary breast tumors showed that a high number of tumor-infiltrating regulatory T cells (Ti-Treg) within lymphoid infiltrates surrounding the tumor was predictive of relapse and death, in contrast to those pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f05fbdd479ec52e643d4dbce83e67450
https://doi.org/10.1158/0008-5472.can-08-2360

Human natural killer cells promote cross-presentation of tumor cell-derived antigens by dendritic cells

Autor: Florence, Deauvieau, Vincent, Ollion, Anne-Claire, Doffin, Carole, Achard, Jean-François, Fonteneau, Estelle, Verronese, Isabelle, Durand, Raffaella, Ghittoni, Jacqueline, Marvel, Colette, Dezutter-Dambuyant, Thierry, Walzer, Henri, Vie, Ivan, Perrot, Nadège, Goutagny, Christophe, Caux, Jenny, Valladeau-Guilemond

Publikováno v: International Journal of Cancer
International Journal of Cancer, Wiley, 2015, 136 (5), pp.1085-1094. ⟨10.1002/ijc.29087⟩
International Journal of Cancer, 2015, 136 (5), pp.1085-1094. ⟨10.1002/ijc.29087⟩

International audience; Dendritic cells (DCs) cross-present antigen (Ag) to initiate T-cell immunity against most infections and tumors. Natural killer (NK) cells are innate cytolytic lymphocytes that have emerged as key modulators of multiple DC fun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ce4acf10972f3fc1afaa7001e4c6fc25
https://www.hal.inserm.fr/inserm-02913986/file/ijc.29087.pdf