Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Anne Chomyn"'
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46473 (2012)
Mitochondrial DNA (mtDNA) is highly polymorphic, and its variations in humans may contribute to individual differences in function. Zhang and colleagues found a strikingly higher frequency of a C150T transition in the D-loop of mtDNA from centenarian
Externí odkaz:
https://doaj.org/article/1e292d017b8343ad9dd5b07e096e329c
Autor:
Anne Chomyn, Sion L. Williams, Carlos T. Moraes, Masami Hashimoto, Marni J. Falk, Sandra R. Bacman, David C. Chan, Susana Peralta
Publikováno v:
Molecular Therapy. 23(10):1592-1599
We have designed mitochondrially targeted transcription activator-like effector nucleases or mitoTALENs to cleave specific sequences in the mitochondrial DNA (mtDNA) with the goal of eliminating mtDNA carrying pathogenic point mutations. To test the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ba5595d7b4debce038b86b3e988e93d
Autor:
Nir Barzilai, Anne Chomyn, Nahoko Iwata, Robert D. Burk, Suzanne M. Leanza, Jin Zhang, Giuseppe Attardi, Jaehyoung Cho, Gil Atzmon
Publikováno v:
Mitochondrion. 7:267-272
Our previous observation that a mitochondrial DNA (mtDNA) homoplasmic C150T transition adjacent to the heavy strand replication origin at position 151 is greatly increased in frequency in Italian centenarians, as compared to the rest of the populatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5c2053d6bccb2b92f410dd57a9eeec0
https://doi.org/10.1016/j.mito.2007.03.001
https://doi.org/10.1016/j.mito.2007.03.001
Autor:
Sabine Hofmann, Giuseppe Attardi, Walter Neupert, Aleksandra Trifunovic, Nils-Göran Larsson, Stéphane Duvezin-Caubet, Matthias F. Bauer, Andreas S. Reichert, Anne Chomyn, Anna Hansson, Ravi Jagasia, Johannes Wagener
Publikováno v:
J. Biol. Chem. 281, 37972 (2006)
Many muscular and neurological disorders are associated with mitochondrial dysfunction and are often accompanied by changes in mitochondrial morphology. Mutations in the gene encoding OPA1, a protein required for fusion of mitochondria, are associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9125938ecd1ca71009a0dede200e42c
https://doi.org/10.1074/jbc.m606059200
https://doi.org/10.1074/jbc.m606059200
Publikováno v:
Journal of Biological Chemistry. 280:26185-26192
Mitochondria undergo continual cycles of fusion and fission, and the balance of these opposing processes regulates mitochondrial morphology. Paradoxically, cells invest many resources to maintain tubular mitochondrial morphology, when reducing both f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0423bb0de44ff9fbed26db2b79a7f3
https://doi.org/10.1074/jbc.m503062200
https://doi.org/10.1074/jbc.m503062200
Autor:
Peiqing Hu, Giuseppe Attardi, Takao Yagi, Anne Chomyn, Xiufeng Song, Yidong Bai, Jian Hong Deng, Jeong Soon Park
Publikováno v:
Annals of the New York Academy of Sciences. 1011:272-283
Mammalian mitochondrial NADH dehydrogenase (complex I) is a multimeric complex consisting of at least 45 subunits, 7 of which are encoded by mitochondrial DNA (mtDNA). The function of these subunits is largely unknown. We have established an efficien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed24feec3386661825914afd243625c
https://doi.org/10.1196/annals.1293.026
https://doi.org/10.1196/annals.1293.026
Autor:
Anne Chomyn, Giuseppe Attardi
Publikováno v:
Biochemical and Biophysical Research Communications. 304:519-529
There is considerable evidence that the oxidative phosphorylation capacity of human mitochondria declines in various tissues with aging. However, the genetic basis of this phenomenon has not yet been clarified. The occurrence of large deletions in mt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c854e36bbc3f5fe7e3ab8cdf6c66912
https://doi.org/10.1016/s0006-291x(03)00625-9
https://doi.org/10.1016/s0006-291x(03)00625-9
Publikováno v:
Journal of Biological Chemistry. 278:1346-1353
We have shown here that the apoptosis inducer staurosporine causes an early decrease in the endogenous respiration rate in intact 143B.TK(-) cells. On the other hand, the activity of cytochrome c oxidase is unchanged for the first 8 h after staurospo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::053ddd36536c8784d0448c23998592d3
https://doi.org/10.1074/jbc.m209269200
https://doi.org/10.1074/jbc.m209269200
Autor:
Anne Chomyn
Publikováno v:
Journal of Bioenergetics and Biomembranes. 33:251-257
Sixteen years ago, we demonstrated, by immunological and biochemical approaches, that seven subunits of complex I are encoded in mitochondrial DNA (mtDNA) and synthesized on mitochondrial ribosomes in mammalian cells. More recently, we carried out a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c20ad15e787dcbfbefe4160b12a5199
https://doi.org/10.1023/a:1010791204961
https://doi.org/10.1023/a:1010791204961
Publikováno v:
Nucleic Acids Research. 27:756-763
Post-transcriptional modifications are characteristic features of tRNAs and have been shown in a number of cases to influence both their structural and functional properties, including structure stabilization, amino-acylation and codon recognition. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b135d4ee570e6dd357eb30969321b59f
https://doi.org/10.1093/nar/27.3.756
https://doi.org/10.1093/nar/27.3.756