Výsledky vyhledávání

Can the genetic factors influence the treatment of systemic hypertension? The case of the renin-angiotensin-aldosterone system

Autor: Pierre Corvol, Xavier Jeunemaitre, Florent Soubrier, Anne Charru

Publikováno v: The American Journal of Cardiology. 70:D14-D20

The hereditary nature of familial hypertension has been clearly established by a number of clinical studies. About 30% of the blood pressure variance can be attributed to genetic factors. As a consequence, the relative risk for developing coronary ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5885184783c318d95cdae8a08b55ac9
https://doi.org/10.1016/0002-9149(92)90267-3

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LIST OF CONTRIBUTORS

Autor: Adriano Aguzzi, Tamara Alliston, Ali Arslan, Indrani C. Bagchi, Milan K. Bagchi, C. Wayne Bardin, Craig L. Best, Julie A. Blendy, Martha M. Bosma, Eugene P. Brandon, Robert E. Braun, D.D. Brown, Nail Burnashev, Jean S. Campbell, Nicholas A. Cataldo, Kevin J. Catt, Pierre Chambon, Anne Charru, J.H. Check, Mitchell I. Chemin, Khoi Chu, James H. Clark, Jeffrey W. Clemens, Timothy J. Cole, Orla M. Conneely, Pierre Corvol, Tamás Csikós, Mark Danielsen, Ying Qing Ding, Carl Djerassi, B. Eliceiri, Adria A. Elskus, Satish A. Eraly, Mark A. Fajardo, Susan L. Fitzpatrick, Victor Y. Fujimoto, J.D. Furlow, Dana Gaddy-Kurten, Ruth Ganss, Frederick W. George, Kirstin A. Gerhold, Paul A. Godfrey, Jonathan D. Graves, Lee M. Graves, L. Earl Gray, Joseph A. Hill, Bertil Hille, Lyann R. Hodgskin, Edith Hummler, David L. Hurley, Rejean L. Idzerda, Robert B. Jaffe, Amy M. Jensen, Xavier Jeunemaitre, A. Kanamori, William R. Kelce, Hansjorg Keller, Paul A. Kelly, John Kirkland, Georg Köhr, Yuri Kotelevtsev, Edwin G. Krebs, David J. Kulik, Thomas Kuner, Agnès Larcher, Mark A. Lawson, Keesook Lee, Diana Lefèbvre, Joanna M. Makris, Shaila Mani, Kelly E. Mayo, G. Stanley McKnight, Jeffrey A. Medin, Pamela L. Mellon, Emily Monosson, Lluis Montoliu, Hannah Monyer, Jaqueline K. Morris, Patricia L. Morris, Lata Murthy, Lynne V. Nazareth, Susan B. Nunez, Bert W. O'Malley, Yoshihiro Okuda, Keiko Ozato, Kathleen Creed Page, Carol J. Phelps, Ming Qi, Jason O. Rahal, Marilyn B. Renfree, Stéphane Richard, JoAnne S. Richards, Mario I. Romero, Elliott M. Ross, Florence Rozen, Radmila Runic, Peter N. Schlegel, Wolfgang Schmid, William T. Schrader, Jill M. Schumacher, Günter Schütz, Neena B. Schwartz, R. Schwartzman, Peter H. Seeburg, James Segars, Rony Seger, B.S. Shanis, Jean Sirois, Carolyn Smith, Florent Soubrier, Rolf Sprengel, George Stancel, Stanko S. Stojilkovic, Steven T. Suhr, Joyce Tay, Vilmos Thomazy, E. Brad Thompson, Philippe Touraine, Amy Tse, Frederick W. Tse, Kunihiro Tsuchida, Wylie Vale, Walter Wahli, Ken Wang, Z. Wang, Nancy L. Weigel, David B. Whyte, Jean D. Wilson, Patrick W. Wojtkiewicz, Shimin Zhang, Hans H. Zingg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0215c608a9fa0d1028ce46fe227d8621
https://doi.org/10.1016/b978-0-12-571150-0.50003-2

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Role of the Renin–Angiotensin System in Blood Pressure Regulation and in Human Hypertension: New Insights from Molecular Genetics

Autor: Anne Charru, Florent Soubrier, Yuri Kotelevtsev, Pierre Corvol, Xavier Jeunemaitre

Publisher Summary This chapter discusses the recent progress made in the molecular genetics of the renin–angiotensin system genes with a special emphasis on human hypertension. The renin–angiotensin system consists of four main proteins: (1) reni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f4ba8b43677d57f4e034ba04e9cc1529
https://doi.org/10.1016/b978-0-12-571150-0.50017-2

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Lack of evidence for linkage of the endothelial cell nitric oxide synthase gene to essential hypertension

Autor: Florent Soubrier, Anne Charru, Xavier Jeunemaitre, Pierre Corvol, Sophie Nadaud, Alain Bonnardeaux

Publikováno v: Circulation. 91(1)

Background The basal release of nitric oxide by the endothelium plays an important role in regulating blood flow and pressure and mediates most of the endothelium-dependent vasodilation. Impairment of nitric oxide production by specific inhibitors in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b6a76240832cf9130b9fb804b26a01f
https://pubmed.ncbi.nlm.nih.gov/7528648

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Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension

Autor: Isabelle Féry, Florent Soubrier, Eric Clauser, Xavier Jeunemaitre, François Cambien, Laurence Tiret, Anne Charru, Pierre Corvol, Alain Bonnardeaux, Eleanor Davies

Publikováno v: Hypertension (Dallas, Tex. : 1979). 24(1)

We conducted the present study to determine whether the angiotensin II type I receptor (AT1) gene might be implicated in human essential hypertension by using case-control and linkage studies. The entire coding and 3' untranslated regions of the AT1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0d66a91b6931f6d682c62c7175019dc
https://pubmed.ncbi.nlm.nih.gov/8021009

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HYPERGENE: a clinical and genetic database for genetic analysis of human hypertension

Autor: Gilles Chatellier, Anne Charru, Florent Soubrier, Xavier Jeunemaitre, Pierre Corvol

Publikováno v: Journal of hypertension. Supplement : official journal of the International Society of Hypertension. 12(7)

Objective Genetic studies of essential human hypertension require the recording and management of numerous data concerning multiple hypertensive families. The present paper describes a new family database, HYPERGENE, and demonstrates its potential us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40c7e84db4b7445e6bb54910bbe89050
https://pubmed.ncbi.nlm.nih.gov/7769503

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Molecular basis of human hypertension: role of angiotensinogen

Autor: Florent Soubrier, Roger R. Williams, Steven C. Hunt, Richard P. Lifton, Jean Marc Lalouel, Yuri Kotelevtsev, Paul N. Hopkins, Christopher S. Williams, Pierre Corvol, Anne Charru, Xavier Jeunemaitre

Publikováno v: Cell. 71(1)

Essential hypertension is a common human disease believed to result from the interplay of multiple genetic and environmental determinants. In genetic studies of two large panels of hypertensive sibships from widely separated geographical areas, we ob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fee4503b2451d7923651943d931b3214
https://pubmed.ncbi.nlm.nih.gov/1394429

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Sib pair linkage analysis of renin gene haplotypes in human essential hypertension

Autor: Anne Charru, Anne-Marie Houot, B Rigat, Xavier Jeunemaitre, Pierre Corvol, Florent Soubrier

Publikováno v: Human genetics. 88(3)

Although essential arterial hypertension is believed to have a strong genetic predisposition, the gene(s) responsible are unknown. The mechanisms underlying the regulation of blood pressure and experimental studies place the renin gene among the main

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8269e3ac7a8f8a24f97d40fde16c2e7
https://pubmed.ncbi.nlm.nih.gov/1346386

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