Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Anne Charlotte Hegelund"'
Autor:
Tine Glendorf, Louise Knudsen, Carsten E Stidsen, Bo F Hansen, Anne Charlotte Hegelund, Anders R Sørensen, Erica Nishimura, Thomas Kjeldsen
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e29198 (2012)
BACKGROUND: Insulin analogues comprising acidic amino acid substitutions at position B10 have previously been shown to display increased mitogenic potencies compared to human insulin and the underlying molecular mechanisms have been subject to much s
Externí odkaz:
https://doaj.org/article/785dcfb71c16461ca83e1abc3e406c8d
Autor:
Kristoffer W. Balling, Brian Lauritzen, Janne Olling, Mads Bjelke, Cecilia Augustsson, Ida Hilden, Anne Charlotte Hegelund, Kristin L. Abel
Publikováno v:
Journal of thrombosis and haemostasis : JTH. 17(3)
Essentials Hemophilia patients on concizumab prophylaxis may need rFVIIa to treat breakthrough bleeds. Effect and safety of concizumab + rFVIIa were tested in vitro and in vivo. Concizumab + rFVIIa had no additive effects on bleeding in hemophilic ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::528632585c3f57299874fefbf22845cf
https://pubmed.ncbi.nlm.nih.gov/30614620
https://pubmed.ncbi.nlm.nih.gov/30614620
Autor:
Kasia E. Cortes, Hong Ji, Anne Charlotte Hegelund, Carl-Magnus Högerkorp, Karen J. Quadrini, Chengsen Xue, Thomas W. Mc Closkey, Susan M. Kennelly
Publikováno v:
Cytometry Part B: Clinical Cytometry. 90:177-190
The C5a/C5a receptor (C5aR) pathway, a key component in the proinflammatory immune response, is an attractive therapeutic target since its dysregulation is implicated in a variety of autoimmune and inflammatory disorders. The objective of the present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cae086df78ca16821899ad2f14a709e
https://doi.org/10.1002/cyto.b.21260
https://doi.org/10.1002/cyto.b.21260
Autor:
Anne Charlotte Hegelund, Toke Folke Christensen, Hong Ji, Ola Sternebring, Lene Alifrangis, Carl-Magnus Högerkorp
Publikováno v:
Cytometry Part B: Clinical Cytometry. 90:220-229
Background Flow cytometry-based receptor occupancy (RO) assessments for pharmacodynamic (PD) response measurements along with drug pharmacokinetic (PK) measurements represent a cornerstone in mechanism based PK/PD modeling of drugs against cell surfa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6080089852861744203a953a9d3910b1
https://doi.org/10.1002/cyto.b.21277
https://doi.org/10.1002/cyto.b.21277
Autor:
Martin B. Oleksiewicz, Jesper Worm, Nils Billestrup, Christine Bonnesen, Bo Falck Hansen, Pernille Bolvig, Anne Lützen, Anne Charlotte Hegelund, Anders Lundby
Publikováno v:
Journal of Applied Toxicology. 35:842-850
There is a medical need for new insulin analogues. Yet, molecular alterations to the insulin molecule can theoretically result in analogues with carcinogenic effects. Preclinical carcinogenicity risk assessment for insulin analogues rests to a large
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95d7abb6b4e528e5d925d000f858961f
https://doi.org/10.1002/jat.3082
https://doi.org/10.1002/jat.3082
Autor:
Anne Charlotte Hegelund, Gitte-Mai Nelander Holm, Marianne B. Jensen, Christine Bonnesen, Martin B. Oleksiewicz, Jonas S. Krabbe, Anders Lundby
Publikováno v:
Journal of Applied Toxicology. 31:329-341
We compared mitogenicity and intracellular signalling by human insulin and the AspB10 (X-10) human insulin analogue in MCF-7 human mammary adenocarcinoma cells. By flow analysis of phosphorylated histone H3 or cell cycle distributions, insulin and X-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c05091a21c04151b84769e1438868e0
https://doi.org/10.1002/jat.1590
https://doi.org/10.1002/jat.1590
Autor:
Lotte, Bjerre Knudsen, Lars Wichmann, Madsen, Søren, Andersen, Kasper, Almholt, Anne S, de Boer, Daniel J, Drucker, Carsten, Gotfredsen, Frederikke Lihme, Egerod, Anne Charlotte, Hegelund, Helene, Jacobsen, Søren Dyring, Jacobsen, Alan C, Moses, Anne-Marie, Mølck, Henriette S, Nielsen, Jette, Nowak, Helene, Solberg, Tu D L, Thi, Milan, Zdravkovic, Ulrik, Moerch
Publikováno v:
Endocrinology. 151:1473-1486
Liraglutide is a glucagon-like peptide-1 (GLP-1) analog developed for type 2 diabetes. Long-term liraglutide exposure in rodents was associated with thyroid C-cell hyperplasia and tumors. Here, we report data supporting a GLP-1 receptor-mediated mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79b3718a29c823e2c2079c2f1b7e568
https://doi.org/10.1210/en.2009-1272
https://doi.org/10.1210/en.2009-1272
Autor:
Ola, Sternebring, Lene, Alifrangis, Toke Folke, Christensen, Hong, Ji, Anne Charlotte, Hegelund, Carl-Magnus, Högerkorp
Publikováno v:
Cytometry. Part B, Clinical cytometry. 90(2)
Flow cytometry-based receptor occupancy (RO) assessments for pharmacodynamic (PD) response measurements along with drug pharmacokinetic (PK) measurements represent a cornerstone in mechanism based PK/PD modeling of drugs against cell surface targets.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::286d0f8e1f8cbf7acb56ee50698bbf34
https://pubmed.ncbi.nlm.nih.gov/26205127
https://pubmed.ncbi.nlm.nih.gov/26205127
Autor:
Torben S. Guldberg, Peter R. Brinck, Inger Thorup, Anne Charlotte Hegelund, Marianne B. Jensen, Ulla K. Thinggaard, Ingrid Sjögren, Henriette S. Nielsen, Lars Fogh Iversen, Martin B. Oleksiewicz, Hanne V. Andersen, Lis Jørgensen
Publikováno v:
Toxicologic Pathology. 33:552-560
Some developmental dual-acting PPARα/γ agonists, such as ragaglitazar, have shown carcinogenic effects in the rodent urinary bladder urothelium after months-years of dosing. We examined early (precancerous) changes in the bladder urothelium of rats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7c61986d6c55074d8bf062939d91022
https://doi.org/10.1080/01926230500214657
https://doi.org/10.1080/01926230500214657
Autor:
Karen J, Quadrini, Anne Charlotte, Hegelund, Kasia E, Cortes, Chengsen, Xue, Susan M, Kennelly, Hong, Ji, Carl-Magnus, Högerkorp, Thomas W, Mc Closkey
Publikováno v:
Cytometry. Part B, Clinical cytometry. 90(2)
The C5a/C5a receptor (C5aR) pathway, a key component in the proinflammatory immune response, is an attractive therapeutic target since its dysregulation is implicated in a variety of autoimmune and inflammatory disorders. The objective of the present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a9b7544227218e35ccb088b1e6023ce8
https://pubmed.ncbi.nlm.nih.gov/26084468
https://pubmed.ncbi.nlm.nih.gov/26084468