Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Anne C Bay-Jensen"'
Autor:
Yi He, Qinlong Zheng, MengMeng Jiang, Shu Sun, Thorbjørn G Christiansen, Moustapha Kassem, Morten A Karsdal, Anne C Bay-Jensen
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0122700 (2015)
The specific degradation of type II collagen and aggrecan by matrix metalloproteinase (MMP)-9, -13 and ADAMTS-4 and -5 (aggrecanase-1 and -2) in the cartilage matrix is a critical step in pathology of osteoarthritis (OA). The aims of this study were:
Externí odkaz:
https://doaj.org/article/a014bfe1612d4022a385ae852778930c
Autor:
Oliver Distler, Britta Maurer, Suzana Jordan, Carina Mihai, Rucsandra Dobrota, Mike Becker, Morten Asser Karsdal, Nicoletta Del Papa, Anne Sofie Siebuhr, Anne-C Bay-Jensen, Pernille Juhl
Publikováno v:
RMD Open, Vol 10, Iss 2 (2024)
Objective Clinical observation suggests that vascular activation and autoimmunity precede remodelling of the extracellular matrix (ECM) in systemic sclerosis (SSc). We challenge this paradigm by hypothesising that ECM biomarkers are already disturbed
Externí odkaz:
https://doaj.org/article/634f22d560e5462fbaa97c1abf5bfba8
Autor:
Anne C Bay-Jensen, Stephanie Wichuk, Inger Byrjalsen, Diana J Leeming, Nathalie Morency, Claus Christiansen, Morten A Karsdal, Walter P Maksymowych
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54504 (2013)
Inflammation driven connective tissue turnover is key in rheumatic diseases, such as ankylosing spondylitis (AS). Few biomarkers are available for measuring disease prognosis or the efficacy of interventions applied in these tissue-related conditions
Externí odkaz:
https://doaj.org/article/64dda34ff78d40f98825d67c9a3e2d50
Autor:
Anne Gitte Loft, Inge Juul Sørensen, Mikkel Østergaard, Susanne J Pedersen, Morten Asser Karsdal, Ole Rintek Madsen, Anne-C Bay-Jensen, Peder Frederiksen, Signe Holm Nielsen, Helena Port, Frederik Christiansen, Sengul Seven
Publikováno v:
RMD Open, Vol 10, Iss 1 (2024)
Objective To explore the potential of a panel of ECM remodelling markers as endotyping tools for axial spondyloarthritis (axSpA) by separating patients into subtypes and investigate how they differ among each other in disease activity scores and resp
Externí odkaz:
https://doaj.org/article/e93364d1901648c3841a9b940360238c
Autor:
Anne C. Bay-Jensen, Mukundan Attur, Jonathan Samuels, Christian S. Thudium, Steven B. Abramson, Morten A. Karsdal
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 5, Iss 3, Pp 100379- (2023)
Background: The lack of disease modifying drugs in Osteoarthritis (OA) may be attributed to the difficulty in robust response based on patient-reported outcomes (PROs) linked to drug mechanism of action. Joint tissue turnover biomarkers are associate
Externí odkaz:
https://doaj.org/article/2f013bd017994433b08da053806363eb
Autor:
Signe Holm Nielsen, Shu Sun, Anne C. Bay-Jensen, Morten Karsdal, Inge Juul Sørensen, Ulrich Weber, Anne Gitte Loft, Gina Kollerup, Gorm Thamsborg, Ole Rintek Madsen, Jakob Møller, Mikkel Østergaard, Susanne Juhl Pedersen
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-10 (2022)
Abstract Background/purpose In axial spondyloarthritis (axSpA) inflammation of the sacroiliac joints and spine is associated with local extracellular matrix (ECM) remodeling of affected tissues. We aimed to investigate the association of ECM metaboli
Externí odkaz:
https://doaj.org/article/d418a3f4babb4d4ba9b8a17bd2d5c1a6
Autor:
Yunyun Luo, Jonathan Samuels, Svetlana Krasnokutsky, Inger Byrjalsen, Virginia B. Kraus, Yi He, Morten A. Karsdal, Steven B. Abramson, Mukundan Attur, Anne C. Bay-Jensen
Publikováno v:
Journal of Orthopaedics and Traumatology, Vol 22, Iss 1, Pp 1-11 (2021)
Abstract Background Osteoarthritis (OA) is a disease with multiple endotypes. A hallmark of OA is loss of cartilage; however, it is evident that the rate of cartilage loss differs among patients, which may partly be attributed to differential capacit
Externí odkaz:
https://doaj.org/article/fe780c80254c4b1aad37ba8138ac360d
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-12 (2021)
Abstract Objective Associations between rheumatoid arthritis (RA) and effect of treatment at the tissue levels are poorly understood. We investigated the scope of released extracellular matrix (ECM) metabolites as a consequence of tissue remodelling
Externí odkaz:
https://doaj.org/article/779cb02ef8624772b8d828596c7106d0
Autor:
Fabienne R. Kloosterman, Anne-Fleur Zwagemaker, Anne C. Bay-Jensen, Marjon H. Cnossen, Marieke J.H.A. Kruip, Frank W.G. Leebeek, Robert Hemke, Mario Maas, Karin Fijnvandraat, Samantha C. Gouw, Michiel Coppens
Publikováno v:
Journal of Thrombosis and Haemostasis. Wiley-Blackwell
Kloosterman, F R, Zwagemaker, A-F, Bay-Jensen, A C, Cnossen, M H, Kruip, M J H A, Leebeek, F W G, Hemke, R, Maas, M, Fijnvandraat, K, Gouw, S C & Coppens, M 2023, ' Poor correlation between biomarkers and MRI-detected joint damage in a cross-sectional study of persons with nonsevere hemophilia A (DYNAMO study) ', Journal of Thrombosis and Haemostasis, vol. 21, no. 7, pp. 1813-1823 . https://doi.org/10.1016/j.jtha.2023.03.030
Kloosterman, F R, Zwagemaker, A-F, Bay-Jensen, A C, Cnossen, M H, Kruip, M J H A, Leebeek, F W G, Hemke, R, Maas, M, Fijnvandraat, K, Gouw, S C & Coppens, M 2023, ' Poor correlation between biomarkers and MRI-detected joint damage in a cross-sectional study of persons with nonsevere hemophilia A (DYNAMO study) ', Journal of Thrombosis and Haemostasis, vol. 21, no. 7, pp. 1813-1823 . https://doi.org/10.1016/j.jtha.2023.03.030
Background: Persons with nonsevere hemophilia A (NSHA) experience less frequent joint bleeding than persons with severe hemophilia A, but may still develop joint damage. Biomarkers of cartilage and synovial remodeling can reflect ongoing pathologic p
Autor:
Patryk J. Drobinski, Neel I. Nissen, Dovile Sinkeviciute, Nicholas Willumsen, Morten A. Karsdal, Anne C. Bay-Jensen
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 321 (2022)
Protein citrullination and degradation by matrix metalloproteinases (MMP) plays a central role in the pathology of rheumatoid arthritis (RA). Autoantibodies are known to target citrullinated vimentin. The aim of this study was to investigate the rela
Externí odkaz:
https://doaj.org/article/cd8e98af83d8460680f868424c9a7f65