Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Anne Brinkø"'
Autor:
Annie Lambert, Ola Blixt, Anne Brinkø, Christian Risinger, Cyrille Grandjean, Henrik H. Jensen
Publikováno v:
Organic Letters
Organic Letters, American Chemical Society, 2019, 21 (18), pp.7544-7548. ⟨10.1021/acs.orglett.9b02811⟩
Brinkø, A, Risinger, C, Lambert, A, Blixt, O, Grandjean, C & Jensen, H H 2019, ' Combining Click Reactions for the One-Pot Synthesis of Modular Biomolecule Mimetics ', Organic Letters, vol. 21, no. 18, pp. 7544-7548 . https://doi.org/10.1021/acs.orglett.9b02811
Organic Letters, American Chemical Society, 2019, 21 (18), pp.7544-7548. ⟨10.1021/acs.orglett.9b02811⟩
Brinkø, A, Risinger, C, Lambert, A, Blixt, O, Grandjean, C & Jensen, H H 2019, ' Combining Click Reactions for the One-Pot Synthesis of Modular Biomolecule Mimetics ', Organic Letters, vol. 21, no. 18, pp. 7544-7548 . https://doi.org/10.1021/acs.orglett.9b02811
Here, we report on the first combined one-pot use of the two so-called "click reactions": the thiol-ene coupling and the copper-catalyzed alkyne-azide cycloaddition. These reactions were employed in an alternating and one-pot fashion to combine appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26fc4759a6ee3c4d5da0e5b5263e59e3
https://doi.org/10.1021/acs.orglett.9b02811
https://doi.org/10.1021/acs.orglett.9b02811
Publikováno v:
Marqvorsen, M H S, Brinkø, A & Jensen, H H 2020, ' On the electron withdrawing nature of ethers in glycosylation chemistry ', Carbohydrate Research, vol. 487, 107886 . https://doi.org/10.1016/j.carres.2019.107886
The present paper is a commentary on the electronic effects that protecting groups exert on glycosylation chemistry. Specifically, its purpose is to rectify the misguided use of the term electron donating benzyl groups, which hardly makes sense in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::110a1fec2fa70b0a7d114427478c0995
https://pure.au.dk/portal/da/publications/on-the-electron-withdrawing-nature-of-ethers-in-glycosylation-chemistry(9ce8141d-c6ac-45c0-b617-20f03309d929).html
https://pure.au.dk/portal/da/publications/on-the-electron-withdrawing-nature-of-ethers-in-glycosylation-chemistry(9ce8141d-c6ac-45c0-b617-20f03309d929).html
Autor:
Heidi Koldsø, Anders Kolind, Maja Thim Larsen, Steffen Sinning, Louise M. Besenbacher, Henrik H. Jensen, Anne Brinkø, Birgit Schiøtt
Publikováno v:
Brinkø, A, Larsen, M T, Koldsø, H, Besenbacher, L M, Kolind, A, Schiøtt, B, Sinning, S & Jensen, H H 2016, ' Synthesis and inhibitory evaluation of 3-linked imipramines for the exploration of the S2 site of the human serotonin transporter ', Bioorganic & Medicinal Chemistry, vol. 24, pp. 2725-2738 . https://doi.org/10.1016/j.bmc.2016.04.039
The human serotonin transporter is the primary target of several antidepressant drugs, and the importance of a primary, high affinity binding site (S1) for antidepressant binding is well documented. The existence of a lower affinity, secondary bindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73ec83f0fec776e6d849fefa6d16ba99
https://doi.org/10.1016/j.bmc.2016.04.039
https://doi.org/10.1016/j.bmc.2016.04.039
Autor:
Anne Brinkø, Christinne Hedberg, Atsushi Kato, Daisuke Ide, Ida M B Knudsen, Espen Eikeland, Henrik H. Jensen, Lucy Kate Ladefoged
Publikováno v:
Knudsen, I M B, Hedberg, C, Ladefoged, L K, Ide, D, Brinkø, A, Eikeland, E Z, Kato, A & Jensen, H H 2018, ' Divergent synthesis of new α-glucosidase inhibitors obtained through a vinyl Grignard-mediated carbocyclisation ', Organic & Biomolecular Chemistry, vol. 16, no. 34, pp. 6250-6261 . https://doi.org/10.1039/c8ob01433g
Four new α-glucosidase inhibitors have been synthesised through 5-8 synthetic steps from a common synthetic intermediate obtained through a recently developed carbocyclisation. The compounds were designed as hybrids of the known glucosidase inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab46c22e907a7539c8a1689e0a6f42c6
https://pubmed.ncbi.nlm.nih.gov/30110037
https://pubmed.ncbi.nlm.nih.gov/30110037
Autor:
Louise J. Walport, Martin Münzel, Anne Brinkø, Gareth W. Langley, Richard J. Hopkinson, Christopher J. Schofield
Publikováno v:
Langley, G W, Brinkø, A, Münzel, M, Walport, L J, Schofield, C J & Hopkinson, R J 2016, ' Analysis of JmjC Demethylase-Catalyzed Demethylation Using Geometrically-Constrained Lysine Analogues ', A C S Chemical Biology, vol. 11, no. 3, pp. 755-762 . https://doi.org/10.1021/acschembio.5b00738
The dynamic post-translational modifications of histones play important roles in the regulation of transcription in animals. The demethylation of N(ε)-methyl lysine residues in the N-terminal tail of histone H3 is catalyzed by demethylases, of which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4a10f97908db3cc858e0882713cef90
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Autor:
Henrik H. Jensen, Steffen Sinning, D. Clive Williams, Sandra A. Bright, Maja Thim Larsen, Anne Brinkø
Publikováno v:
Bright, S A, Brinkø, A, Larsen, M T, Sinning, S, Williams, D C & Jensen, H H 2013, ' Basic N-interlinked imipramines show apoptotic activity against malignant cells including Burkitt's lymphoma ', Bioorganic & Medicinal Chemistry Letters, vol. 23, no. 5, pp. 1220-4 . https://doi.org/10.1016/j.bmcl.2013.01.020
We here report the synthesis of ethylene glycol N-interlinked imipramine dimers of various lengths from the tricyclic antidepressant desipramine via an amide coupling reaction followed by reduction with lithium aluminium hydride. The target molecules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c6111a08fa670d7040b4e0413038c3
https://pure.au.dk/portal/da/publications/basic-ninterlinked-imipramines-show-apoptotic-activity-against-malignant-cells-including-burkitts-lymphoma(066dbd30-8114-4053-b63d-bbd90d61283e).html
https://pure.au.dk/portal/da/publications/basic-ninterlinked-imipramines-show-apoptotic-activity-against-malignant-cells-including-burkitts-lymphoma(066dbd30-8114-4053-b63d-bbd90d61283e).html