hnRNPA1/UP1 Unfolds KRAS G‑Quadruplexes and Feeds a Regulatory Axis Controlling Gene Expression

Autor: Annalisa Ferino, Julien Marquevielle, Himanshi Choudhary, Giorgio Cinque, Coralie Robert, Anne Bourdoncle, Raffaella Picco, Jean-Louis Mergny, Gilmar F. Salgado, Luigi E. Xodo

Publikováno v: ACS Omega, Vol 6, Iss 49, Pp 34092-34106 (2021)

Externí odkaz: https://doaj.org/article/6d6584fbad484cc3a33b03455540ba6a

Supplementary Figure S3 from RNA Interference Using c-Myc–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models

Autor: Lekha Dinesh Kumar, Alan R. Clarke, K. Swaminathan Iyer, Igor Luzinov, Anne Bourdoncle, Bogdan Zdyrko, Nicole M. Smith, Jedy Jose, Anant B. Patel, Liza E. Alexander, Rekha A. Nair, Meera Raja, Ganesh Mahidhara, Trevor Hay, Syed S. Beevi, Tristan D. Clemons, Vinod K. Verma, Naveen K. Tangudu

Supplementary Figure S3: Toxicity studies of the nanoparticle in different organs.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fa07d4cec77a62ae610653b9cf4b4a8
https://doi.org/10.1158/1535-7163.22502584

Supplementary Table S1 from RNA Interference Using c-Myc–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models

Autor: Lekha Dinesh Kumar, Alan R. Clarke, K. Swaminathan Iyer, Igor Luzinov, Anne Bourdoncle, Bogdan Zdyrko, Nicole M. Smith, Jedy Jose, Anant B. Patel, Liza E. Alexander, Rekha A. Nair, Meera Raja, Ganesh Mahidhara, Trevor Hay, Syed S. Beevi, Tristan D. Clemons, Vinod K. Verma, Naveen K. Tangudu

Supplementary Table S1: Forward and Reverse primers used for quantitative pcr analysis of various genes like c-Myc,p53,GAPDH,NONO and U6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c450a176cc2415546e3f3f4b75a455a
https://doi.org/10.1158/1535-7163.22502569.v1

hnRNPA1/UP1 Unfolds KRAS G-Quadruplexes and Feeds a Regulatory Axis Controlling Gene Expression

Autor: Gilmar F. Salgado, Jean-Louis Mergny, Giorgio Cinque, Coralie Robert, Luigi E. Xodo, Annalisa Ferino, Raffaella Picco, Julien Marquevielle, Anne Bourdoncle, Himanshi Choudhary

Publikováno v: ACS Omega
ACS Omega, ACS Publications, 2021, 6 (49), pp.34092-34106. ⟨10.1021/acsomega.1c05538⟩
ACS Omega, Vol 6, Iss 49, Pp 34092-34106 (2021)

Recent studies have proven that the genetic landscape of pancreatic cancer is dominated by the KRAS oncogene. Its transcription is controlled by a G-rich motif (called 32R) located immediately upstream of the TSS. 32R may fold into a G-quadruplex (G4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf032e5b3d4d5b55e3c214b92d1a1572
http://europepmc.org/articles/PMC8675163

Unexpected Position-Dependent Effects of Ribose G-Quartets in G-Quadruplexes

Autor: Yunqiang Bian, Jun Zhou, Hisae Tateishi-Karimata, Valérie Gabelica, Daisuke Miyoshi, Jean-Louis Mergny, Samir Amrane, Naoki Sugimoto, Dursun Nizam Korkut, Jian Zhang, Wei Wang, Anne Bourdoncle, Frédéric Rosu, Gilmar F. Salgado, Huangxian Ju, Eric Largy

Publikováno v: Journal of the American Chemical Society. 139:7768-7779

To understand the role of ribose G-quartets and how they affect the properties of G-quadruplex structures, we studied three systems in which one, two, three, or four deoxyribose G-quartets were substituted with ribose G-quartets. These systems were a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87854e7d904a61389b369489ae016b84
https://doi.org/10.1021/jacs.7b00648