Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Anne Bothmer"'
Autor:
Georgia Giannoukos, Dawn M. Ciulla, Eugenio Marco, Hayat S. Abdulkerim, Luis A. Barrera, Anne Bothmer, Vidya Dhanapal, Sebastian W. Gloskowski, Hariharan Jayaram, Morgan L. Maeder, Maxwell N. Skor, Tongyao Wang, Vic E. Myer, Christopher J. Wilson
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-10 (2018)
Abstract Background Understanding the diversity of repair outcomes after introducing a genomic cut is essential for realizing the therapeutic potential of genomic editing technologies. Targeted PCR amplification combined with Next Generation Sequenci
Externí odkaz:
https://doaj.org/article/85150464620e4b6d8346790e56c87003
Autor:
Anne Bothmer, Tanushree Phadke, Luis A. Barrera, Carrie M Margulies, Christina S. Lee, Frank Buquicchio, Sean Moss, Hayat S. Abdulkerim, William Selleck, Hariharan Jayaram, Vic E. Myer, Cecilia Cotta-Ramusino
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
CRISPR-Cas9 has rapidly become a common molecular biology tool for modifying genomes and has been modified to generate single-strand nicks as well as double-strand breaks. Here the authors explore the DNA repair pathways activated by the different va
Externí odkaz:
https://doaj.org/article/0e7ab32becea4c83bb655f0d5113f731
Autor:
Arito Yamane, Davide F. Robbiani, Wolfgang Resch, Anne Bothmer, Hirotaka Nakahashi, Thiago Oliveira, Philipp C. Rommel, Eric J. Brown, Andre Nussenzweig, Michel C. Nussenzweig, Rafael Casellas
Publikováno v:
Cell Reports, Vol 3, Iss 1, Pp 138-147 (2013)
Activation-induced cytidine deaminase (AID) promotes chromosomal translocations by inducing DNA double-strand breaks (DSBs) at immunoglobulin (Ig) genes and oncogenes in the G1 phase. RPA is a single-stranded DNA (ssDNA)-binding protein that associat
Externí odkaz:
https://doaj.org/article/aaf8f984f0064196a3769b21974613df
Autor:
Cecilia Cotta-Ramusino, Hayat S Abdulkerim, Eugenio Marco, Frank Buquicchio, Cecilia Fernández, John A. Zuris, Lucas Cohen, Ramya Viswanathan, Kenneth W Gareau, Anne Bothmer, Vic E. Myer
Publikováno v:
The CRISPR Journal. 3:177-187
Multiplexed genome editing with DNA endonucleases has broad application, including for cellular therapies, but chromosomal translocations, natural byproducts of inducing simultaneous genomic breaks, have not been explored in detail. Here we apply var
Autor:
Danny Simpson, Cecilia Cotta-Ramusino, Dian Yang, Jia Ling, Ann Cirincione, Anne Bothmer, Jun Yan, Jeffrey A. Hussmann, Britt Adamson, Jonathan S. Weissman, Albert Xu, Purnima Ravisankar
SUMMARYCells repair DNA double-strand breaks (DSBs) through a complex set of pathways that are critical for maintaining genomic integrity. Here we present Repair-seq, a high-throughput screening approach that measures the effects of thousands of gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::221acd3f95996489cc21170957983674
https://doi.org/10.1101/2021.06.14.448344
https://doi.org/10.1101/2021.06.14.448344
Autor:
Britt Adamson, Albert Xu, Jonathan S. Weissman, Jia Ling, Purnima Ravisankar, Cecilia Cotta-Ramusino, Anne Bothmer, Danny Simpson, Dian Yang, Jeffrey A. Hussmann, Ann Cirincione, Jun Yan
Publikováno v:
Cell
Cells repair DNA double-strand breaks (DSBs) through a complex set of pathways critical for maintaining genomic integrity. To systematically map these pathways, we developed a high-throughput screening approach called Repair-seq that measures the eff
Autor:
Luis A. Barrera, Hayat S Abdulkerim, Frank Buquicchio, Hariharan Jayaram, Carrie M Margulies, Tanushree Phadke, Christina S. Lee, Anne Bothmer, William Selleck, Sean Moss, Vic E. Myer, Cecilia Cotta-Ramusino
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Nature Communications
Nature Communications
The CRISPR–Cas9 system provides a versatile toolkit for genome engineering that can introduce various DNA lesions at specific genomic locations. However, a better understanding of the nature of these lesions and the repair pathways engaged is criti
Autor:
Maria Paola Martelli, Modi Safra, Aldo Mele, Daphna Nachmani, Olivier Bluteau, Ke Cheng, Tom Vulliamy, Dietmar Bothmer, Silvia Grisendi, Assaf C. Bester, Jonathan D. Lee, John G. Clohessy, Olga Pozdnyakova, Emanuele Monteleone, Inderjeet Dokal, Lucio Luzzatto, Keisuke Ito, Robert B. Darnell, Brunangelo Falini, Schraga Schwartz, Caitlin A. Mitchell, Alison Guzzetti, Lourdes M. Mendez, Jean Soulier, Yang Zhang, Anne Bothmer, Paolo Sportoletti, Pier Paolo Pandolfi
Publikováno v:
Nature Genetics
Nature genetics
Nature genetics
RNA modifications are emerging as key determinants of gene expression. However, compelling genetic demonstrations of their relevance to human disease are lacking. Here, we link ribosomal RNA 2'-O-methylation (2'-O-Me) to the etiology of dyskeratosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5bce9af06111dfd64a3ac79aa33964f
Autor:
Vic E. Myer, Wilson Cj, Anne Bothmer, Eugenio Marco, Deepak Reyon, Fernandez Ca, Morgan L. Maeder, Luis A. Barrera, Cecilia Cotta-Ramusino, George M. Church, Cox Gf, Jayaram H, Timothy Fennell, Albright Cf
The recent correspondence to the Editor of Nature Methods by Schaefer et. al. has garnered significant attention since its publication as a result of its strong conclusions contradicting numerous publications in the field using similar analytical app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de4bbbeb861514dc16a4adc4ab304b5
Autor:
Hariharan Jayaram, Christine D. Wilson, Eugenio Marco, Deepak Reyon, Cecilia Fernández, Charles F Albright, Cecilia Cotta-Ramusino, Luis A. Barrera, Vic E. Myer, Morgan L. Maeder, Timothy Fennell, George M. Church, Gerald F. Cox, Anne Bothmer
Publikováno v:
Nature Methods. 15:236-237