Výsledky vyhledávání - "Anne Birgitte Undén"

Non-melanoma skin cancer: pathogenesis and mechanisms

Autor: Anne Birgitte Undén, Matthias Lauth, Rune Toftgård

Publikováno v: Drug Discovery Today: Disease Mechanisms. 1:267-272

Non-melanoma skin cancers (NMSCs) constitute the major fraction of tumours encountered in the Western world. Currently, no mechanism-based treatments exist for either of the major tumour types, basal cell carcinoma and squamous cell carcinoma. Yet, r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b55689e77eb8cd74f9a4a12187c33d9
https://doi.org/10.1016/j.ddmec.2004.09.005

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Role for ELOVL3 and Fatty Acid Chain Length in Development of Hair and Skin Function

Autor: Per Flodby, Rune Toftgård, Mario R. Capecchi, Anders Jacobsson, Petr Tvrdik, Peter M. Elias, Anne Birgitte Undén, Abolfazl Asadi, Walter H. Holleran, Andreas Jakobsson, Lars Norlén, Rolf Westerberg, Jan Erik Månsson

Publikováno v: Journal of Biological Chemistry. 279:5621-5629

Very little is known about the in vivo regulation of mammalian fatty acid chain elongation enzymes as well as the role of specific fatty acid chain length in cellular responses and developmental processes. Here, we report that the Elovl3 gene product

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a2bdb1e454eba7e0673efba2d200429
https://doi.org/10.1074/jbc.m310529200

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Deregulation of the hedgehog signalling pathway: a possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma development

Autor: Rune Toftgård, Carl Johan Malm, Anne Birgitte Undén, Lars-Gunnar Kindblom, Jeanne M. Meis-Kindblom, Ulrica Tostar

Publikováno v: The Journal of pathology. 208(1)

The naevoid basal cell carcinoma syndrome (NBCCS) is caused by mutations in the hedgehog receptor PTCH gene. It is characterized by developmental defects and a predisposition to the development of certain tumours, such as basal cell carcinoma, medull

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::147ca2a3520a172dd596dcce38de4fdd
https://pubmed.ncbi.nlm.nih.gov/16294371

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Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1

Autor: Anne Birgitte Undén, Rune Toftgård, Nikhil S. Chari, Sangjun Lee, Timothy J. McDonnell, Kevin B. Spurgers, Rebecca L. H. Bigelow, Dennis R. Roop

Publikováno v: The Journal of biological chemistry. 279(2)

Basal cell carcinomas (BCCs) express high levels of the antiapoptotic proto-oncogene, bcl-2, and we have shown that bcl-2 contributes to the malignant phenotype in a transgenic mouse model. The basis of bcl-2 transcriptional regulation in keratinocyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b33678b77c36b406cac40c3520c5659
https://pubmed.ncbi.nlm.nih.gov/14555646

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Alternative first exons of PTCH1 are differentially regulated in vivo and may confer different functions to the PTCH1 protein

Autor: Darren Krause, Anne Birgitte Undén, Rune Toftgård, Priit Kogerman, Fahimeh Rahnama, Peter G. Zaphiropoulos, Lembi Kogerman

Publikováno v: Oncogene. 21(39)

The PTCH1 gene is a human tumour suppressor gene frequently mutated in basal cell carcinoma (BCC) and several other tumour types. It encodes a receptor for soluble factors of the hedgehog family. Binding of hedgehog to the receptor relieves its inhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a168070ba9b505cbf613feb5eac4a3ea
https://pubmed.ncbi.nlm.nih.gov/12203113

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PATCHED and p53 gene alterations in sporadic and hereditary basal cell cancer

Autor: Åsa Persson, Fredrik Pontén, Gao Ling, Gijs B. Afink, Rune Toftgård, Cecilia Williams, Afshin Ahmadian, Joakim Lundeberg, Anne Birgitte Undén, Mathias Uhlén

Publikováno v: Oncogene, 20(53), 7770-7778. Nature Publishing Group
Karolinska Institutet

It is widely accepted that disruption of the hedgehog-patched pathway is a key event in development of basal cell cancer. In addition to patched gene alterations, p53 gene mutations are also frequent in basal cell cancer. We determined loss of hetero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29acaf7b8c6ece6835dce12c82ec4294
https://pure.amc.nl/en/publications/patched-and-p53-gene-alterations-in-sporadic-and-hereditary-basal-cell-cancer(590786d5-81a9-4db5-9db6-d709041e57d2).html

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Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1

Autor: Rune Toftgård, Peter G. Zaphiropoulos, Thomas Grimm, Lembi Kogerman, Darren Krause, Anne Birgitte Undén, Priit Kogerman, Bengt Sandstedt

Publikováno v: Nature cell biology. 1(5)

Sonic hedgehog, Patched and Gli are components of a mammalian signalling pathway that has been conserved during evolution and which has a central role in the control of pattern formation and cellular proliferation during development. Here we identify

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4d03a3f56247bef9b0fa2fd21a5c8a
https://pubmed.ncbi.nlm.nih.gov/10559945

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The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas

Autor: Mae R. Gailani, Peter G. Zaphiropoulos, Douglas E. Brash, M Ståhle-Bäckdahl, C. Pressman, M Glynn, Anne Birgitte Undén, Rune Toftgård, David J. Leffell, Allen E. Bale, Michael Dean

Publikováno v: Karolinska Institutet

Basal cell carcinoma (BCC) is the most common cancer in humans. The majority of sporadic BCCs have allele loss on chromosome 9q22 implying that inactivation of a tumour suppressor in this region is an important step in BCC formation. The gene for nev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63fbd0fb66ef5e3023bc9fa7b3bd6fd2
https://pubmed.ncbi.nlm.nih.gov/8782809

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Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome

Publikováno v: Karolinska Institutet

The nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant disorder characterized by multiple basal cell carcinomas (BCCs), pits of the palms and soles, jaw keratocysts, a variety of other tumors, and developmental abnormalities. NBCCS

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