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Akademický článek

PR3 and elastase alter PAR1 signaling and trigger vWF release via a calcium-independent mechanism from glomerular endothelial cells.

Autor: Samantha P Tull, Anne Bevins, Sahithi Jyothsna Kuravi, Simon C Satchell, Bahjat Al-Ani, Stephen P Young, Lorraine Harper, Julie M Williams, George Ed Rainger, Caroline O S Savage

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e43916 (2012)

Neutrophil proteases, proteinase-3 (PR3) and elastase play key roles in glomerular endothelial cell (GEC) injury during glomerulonephritis. Endothelial protease-activated receptors (PARs) are potential serine protease targets in glomerulonephritis. W

Externí odkaz: https://doaj.org/article/a2e295cee5e945f693e5615d7542b4eb

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Neutrophil serine proteases mediate inflammatory cell recruitment by glomerular endothelium and progression towards dysfunction

Autor: Julie M. Williams, G. Ed Rainger, Lorraine Harper, Simon C. Satchell, Caroline O. S. Savage, Samantha Tull, Anne Bevins, Sahithi J. Kuravi

Publikováno v: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 27(12)

Background. Neutrophil recruitment into glomerular tissues and reduced capillary wall integrity has been implicated in the development of vasculitic glomerulonephritis (VGN). This study investigated the stages and mechanisms through which neutrophil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b33514ca53d91b04a25f915755e3fee6
https://pubmed.ncbi.nlm.nih.gov/22785107

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PR3 and elastase alter PAR1 signaling and trigger vWF release via a calcium-independent mechanism from glomerular endothelial cells

Autor: Lorraine Harper, Anne Bevins, Julie M. Williams, George Rainger, Bahjat Al-Ani, Stephen P. Young, Simon C. Satchell, Sahithi J. Kuravi, Caroline O. S. Savage, Samantha Tull

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e43916 (2012)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ac7ed97d3a230fa3ffa7effd4d6f2c2
http://europepmc.org/articles/PMC3430624?pdf=render

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An International Study of High Cut-off Hemodialysis for the Management of Myeloma Kidney

Autor: Graham P. Mead, Anne Bevins, Mark Cook, Colin A. Hutchison

Publikováno v: Blood. 118:3974-3974

Abstract 3974 Background: An early reduction in serum free light chains (FLC) improves outcomes for patients with myeloma kidney. The purpose of this study was to assess how high cut-off (HCO) dialysers are being used internationally to achieve this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0933cf831493652f4656220bec03158a
https://doi.org/10.1182/blood.v118.21.3974.3974

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