Diacylglycerol kinase and phospholipase D inhibitors alter the cellular lipidome and endosomal sorting towards the Golgi apparatus

Autor: Michal A. Surma, Anne Berit Dyve Lingelem, Simona Kavaliauskiene, Tore Skotland, Christian Klose, Ruth Halsne, Tove Irene Klokk, Kirsten Sandvig

Publikováno v: Cellular and Molecular Life Sciences

The membrane lipids diacylglycerol (DAG) and phosphatidic acid (PA) are important second messengers that can regulate membrane transport by recruiting proteins to the membrane and by altering biophysical membrane properties. DAG and PA are involved i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02713700c22f2e4b68fed1f61a2d35b9
https://doi.org/10.1007/s00018-020-03551-6

Geldanamycin Enhances Retrograde Transport of Shiga Toxin in HEp-2 Cells.

Autor: Anne Berit Dyve Lingelem, Ieva Ailte Hjelseth, Roger Simm, Maria Lyngaas Torgersen, Kirsten Sandvig

Publikováno v: PLoS ONE, Vol 10, Iss 5, p e0129214 (2015)

The heat shock protein 90 (Hsp90) inhibitor geldanamycin (GA) has been shown to alter endosomal sorting, diverting cargo destined for the recycling pathway into the lysosomal pathway. Here we investigated whether GA also affects the sorting of cargo

Externí odkaz: https://doaj.org/article/80cd133425514fad8f5723b268de9d9d

Mass spectrometry-based measurements of cyclic adenosine monophosphate in cells, simplified using reversed phase liquid chromatography with a polar characterized stationary phase

Autor: Tsjokajev, Ahmad, Røberg-Larsen, Hanne, Wilson, Steven Ray Haakon, Anne Berit Dyve, Lingelem, Skotland, Tore, Sandvig, Kirsten, Lundanes, Elsa

Publikováno v: Tsjokajev, Ahmad Røberg-Larsen, Hanne Wilson, Steven Ray Haakon Anne Berit Dyve, Lingelem Skotland, Tore Sandvig, Kirsten Lundanes, Elsa . Mass spectrometry-based measurements of cyclic adenosine monophosphate in cells, simplified using reversed phase liquid chromatography with a polar characterized stationary phase. Jo
Jo

Externí odkaz: http://hdl.handle.net/10852/84011
https://www.duo.uio.no/bitstream/handle/10852/84011/4/1-s2.0-S1570023220308898-main.pdf

Novel actions of 2-deoxy-D-glucose: protection against Shiga toxins and changes in cellular lipids

Autor: Tore Skotland, Kim Ekroos, Helena Simolin, Maria Lyngaas Torgersen, Tuulia Sylvänne, Tove Irene Klokk, Roger Simm, Simona Kavaliauskiene, Kirsten Sandvig, Anne Berit Dyve Lingelem

Publikováno v: Biochemical Journal. 470:23-37

2-Deoxy-D-glucose (2DG) is a structural analogue of glucose with well-established applications as an inhibitor of glycolysis and N-glycosylation. Importantly, 2DG has been shown to improve the efficacy of several cancer chemotherapeutic agents in viv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c120e89f46a5b405d3894d8c03fb4e77
https://doi.org/10.1042/bj20141562

Protection against Shiga Toxins

Autor: Kirsten Sandvig, Simona Kavaliauskiene, Tore Skotland, Anne Berit Dyve Lingelem

Publikováno v: Toxins, Vol 9, Iss 2, p 44 (2017)
Toxins

Shiga toxins consist of an A-moiety and five B-moieties able to bind the neutral glycosphingolipid globotriaosylceramide (Gb3) on the cell surface. To intoxicate cells efficiently, the toxin A-moiety has to be cleaved by furin and transported retrogr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3fc08c0325b287a5c727563b17ed1d4
http://hdl.handle.net/10852/61209