Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Anne B. Need"'
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Akademický článek
Glucose metabolic trapping in mouse arteries: nonradioactive assay of atherosclerotic plaque inflammation applicable to drug discovery.
Autor: Richard G Conway, Eyassu Chernet, David C De Rosa, Robert J Benschop, Anne B Need, Emily C Collins, James S Bean, J Michael Kalbfleisch, Mark D Rekhter
Publikováno v: PLoS ONE, Vol 7, Iss 11, p e50349 (2012)
(18)F-Fluorodeoxyglucose (FDG)-positron emission tomography (PET) imaging of atherosclerosis in the clinic is based on preferential accumulation of radioactive glucose analog in atherosclerotic plaques. FDG-PET is challenging in mouse models due to l
Externí odkaz: https://doaj.org/article/f41871f555ec4207b4e3c75e279b22fc
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Approaches for the discovery of novel positron emission tomography radiotracers for brain imaging
Autor: Anne B. Need, Vanessa N. Barth, Nancy Kant, Cynthia Darshini Jesudason
Publikováno v: Clinical and Translational Imaging. 5:265-274
Positron emission tomography (PET) is a widely used imaging technique with many biomedical and drug development applications. The implementation of this technology requires the availability of selective radiotracers with suitable physicochemical char
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cbdc6d67130d034259fb9b3456a632eb
https://doi.org/10.1007/s40336-017-0221-3
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LLY-2707, A Novel Nonsteroidal Glucocorticoid Antagonist That Reduces Atypical Antipsychotic–Associated Weight Gain in Rats
Autor: Anne B. Need, Jesline T. Alexander-Chacko, Donald R. Gehlert, Dana Sindelar, Janice Shaw, Matthew W. Carson, Robert J. Barr, Michael J. Coghlan, Michelle Morin
Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 348:192-201
Weight gain and diabetes have been reported during treatment with atypical antipsychotic drugs (AAPDs). Patients treated with the glucocorticoid receptor antagonist (GRA) and the progesterone receptor antagonist (PRA) mifepristone [estra-4,9-dien-3-o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e0a3bb954856a4db9716ecb2d749835
https://doi.org/10.1124/jpet.113.205864
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Analgesic effects of serotonergic, noradrenergic or dual reuptake inhibitors in the carrageenan test in rats: Evidence for synergism between serotonergic and noradrenergic reuptake inhibition
Autor: Anne B. Need, Carrie K. Jones, Harlan E. Shannon, Brian J. Eastwood
Publikováno v: Neuropharmacology. 51:1172-1180
The efficacy of antidepressant drugs with serotonergic, noradrenergic, or dual reuptake inhibition was evaluated in reversing carrageenan-induced thermal hyperalgesia and mechanical allodynia in rats. Duloxetine (1–30 mg/kg, i.p.), a balanced serot
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f2ff2874c594493500daa25a3114a2b
https://doi.org/10.1016/j.neuropharm.2006.08.005
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Metabotropic Glutamate 5 Receptor Antagonism Is Associated with Antidepressant-Like Effects in Mice
Autor: Anne B. Need, Melvyn Baez, Xia Li, Jeffrey M. Witkin
Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 319:254-259
Antidepressant-like effects of metabotropic glutamate (mGlu)5 receptor antagonists have been reported previously. We now provide definitive identification of mGlu5 receptors as a target for these effects through the combined use of selective antagoni
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::926d5521af2bad1ef9ff4a777a8b62a7
https://doi.org/10.1124/jpet.106.103143
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8
Comparison of rat dopamine D2 receptor occupancy for a series of antipsychotic drugs measured using radiolabeled or nonlabeled raclopride tracer
Autor: Laura J. Martin, Eyassu Chernet, Anne B. Need, Lee A. Phebus, Michelle Morin, Karen S. Rash, Vanessa N. Barth
Publikováno v: Life Sciences. 78:3007-3012
Preclinical brain receptor occupancy measures have heretofore been conducted by quantifying the brain distribution of a radiolabeled tracer ligand using either scintillation spectroscopy or tomographic imaging. For smaller animals like rodents, the m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::925ec0f492c25abb44d27f4e2b7a3b5e
https://doi.org/10.1016/j.lfs.2005.11.031
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Use of LC/MS to assess brain tracer distribution in preclinical, in vivo receptor occupancy studies: Dopamine D2, serotonin 2A and NK-1 receptors as examples
Autor: Vanessa N. Barth, Laura J. Martin, Karen S. Rash, Eyassu Chernet, Dominic L. Li, Lee A. Phebus, Anne B. Need
Publikováno v: Life Sciences. 78:340-346
High performance liquid chromatography combined with either single quad or triple quad mass spectral detectors (LC/MS) was used to measure the brain distribution of receptor occupancy tracers targeting dopamine D2, serotonin 5-HT2A and neurokinin NK-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52924ed5add17de42b1e6555ed9e7426
https://doi.org/10.1016/j.lfs.2005.04.075
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The relationship of in vivo central CB1 receptor occupancy to changes in cortical monoamine release and feeding elicited by CB1 receptor antagonists in rats
Autor: George G. Nomikos, Eyassu Chernet, Brian J. Eastwood, Richard J. Davis, Dana Sindelar, Lee A. Phebus, Anne B. Need, Jesline T. Alexander-Chacko
Publikováno v: Psychopharmacology. 184:26-35
Cannabinoid type 1 (CB(1)) receptor antagonists are reportedly effective in reducing food intake both preclinically and clinically. This may be due in part to their effects on monoamine release in the brain. The level of central CB(1) receptor occupa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b39fa1d9db59439a8fc4e4a1284a1be
https://doi.org/10.1007/s00213-005-0234-x
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