Výsledky vyhledávání - "Anne B. Kristensen"

Akademický článek

Protective efficacy of the anti-HIV broadly neutralizing antibody PGT121 in the context of semen exposure

Autor: Matthew S. Parsons, Anne B. Kristensen, Kevin J. Selva, Wen Shi Lee, Thakshila Amarasena, Robyn Esterbauer, Adam K. Wheatley, Benjamin R. Bavinton, Anthony D. Kelleher, Andrew E. Grulich, Georges Khoury, Jennifer A. Juno, Stephen J. Kent

Publikováno v: EBioMedicine, Vol 70, Iss , Pp 103518- (2021)

Background: HIV-1 infections occur following viral exposure at anogenital mucosal surfaces in the presence of semen. Semen contains immunosuppressive and pro-inflammatory factors. Semen from HIV-1-infected donors contains anti-HIV-1 antibodies. We as

Externí odkaz: https://doaj.org/article/dd1e6f70ef79467f9bca32d7896dcc2d

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Akademický článek

High CD26 and Low CD94 Expression Identifies an IL-23 Responsive Vδ2+ T Cell Subset with a MAIT Cell-like Transcriptional Profile

Autor: Kathleen M. Wragg, Hyon-Xhi Tan, Anne B. Kristensen, Catriona V. Nguyen-Robertson, Anthony D. Kelleher, Matthew S. Parsons, Adam K. Wheatley, Stuart P. Berzins, Daniel G. Pellicci, Stephen J. Kent, Jennifer A. Juno

Publikováno v: Cell Reports, Vol 31, Iss 11, Pp 107773- (2020)

Summary: Vδ2+ T cells play a critical role in immunity to micro-organisms and cancer but exhibit substantial heterogeneity in humans. Here, we demonstrate that CD26 and CD94 define transcriptionally, phenotypically, and functionally distinct Vδ2+ T

Externí odkaz: https://doaj.org/article/d7b6ee55cfda4c1b9c137a57e55e6253

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Phenotypic and functional characteristics of highly differentiated CD57+NKG2C+ NK cells in HIV-1-infected individuals

Autor: Anne B Kristensen, Kathleen M Wragg, Hillary A Vanderven, Wen Shi Lee, Julie Silvers, Helen E Kent, Michael D Grant, Anthony D Kelleher, Jennifer A Juno, Stephen J Kent, Matthew S Parsons

Publikováno v: Clinical and Experimental Immunology. 210:163-174

Natural killer (NK) cells are important anti-viral effector cells. The function and phenotype of the NK cells that constitute an individual’s NK cell repertoire can be influenced by ongoing or previous viral infections. Indeed, infection with human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7f8f5b7ee27b38dc25a24910477c2ef
https://doi.org/10.1093/cei/uxac082

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Enhancement of Antibody-Dependent Cellular Cytotoxicity and Phagocytosis in Anti-HIV-1 Human-Bovine Chimeric Broadly Neutralizing Antibodies

Autor: Bruce D. Wines, Matthew S. Parsons, Anne B. Kristensen, Christopher A Gonelli, Behnaz Heydarchi, Jack Edwards, Damian F. J. Purcell, Georges Khoury, Natalia Salazar-Quiroz, P. Mark Hogarth

Publikováno v: J Virol

No prophylactic vaccine has provided robust protection against human immunodeficiency virus type 1 (HIV-1). Vaccine-induced broadly neutralizing antibodies (bNAbs) have not been achieved in humans and most animals; however, cows vaccinated with HIV-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76cf22b8ee70f91dcef329d33abc155b
https://doi.org/10.1128/jvi.00219-21

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High CD26 and Low CD94 Expression Identifies an IL-23 Responsive Vδ2+ T Cell Subset with a MAIT Cell-like Transcriptional Profile

Autor: Matthew S. Parsons, Anthony D. Kelleher, Kathleen M. Wragg, Stephen J. Kent, Hyon-Xhi Tan, Stuart P. Berzins, Daniel G. Pellicci, Adam K. Wheatley, Anne B. Kristensen, Jennifer A Juno, Catriona V. Nguyen-Robertson

Publikováno v: Cell Reports, Vol 31, Iss 11, Pp 107773-(2020)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bb3470e84bdd5c71fa807495186d079
http://www.sciencedirect.com/science/article/pii/S2211124720307531

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Fc-dependent functions are redundant to efficacy of anti-HIV antibody PGT121 in macaques

Autor: Wen Shi Lee, Miles P. Davenport, Adam K. Wheatley, P. Mark Hogarth, Matthew S. Parsons, Stephen J. Kent, Arnold Reynaldi, Anne B. Kristensen, Bruce D. Wines, Thakshila Amarasena, Georges Khoury

Publikováno v: Journal of Clinical Investigation. 129:182-191

A considerable body of evidence suggests that Fc-dependent functions improve the capacity of broadly neutralizing antibodies (BnAbs) to protect against and control HIV-1 infection. This phenomenon, however, has not been formally tested in robust cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93a108508a987acea769619b2f05c6b4
https://doi.org/10.1172/jci122466

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Effect of Combination Antiretroviral Therapy on HIV-1-specific Antibody-Dependent Cellular Cytotoxicity Responses in Subtype B- and Subtype C-Infected Cohorts

Autor: David A. Cooper, Bruce D. Wines, P.M. Hogarth, Janaki Amin, Sean Emery, Vijaya Madhavi, Matthew S. Parsons, Milla R. McLean, Stephen J. Kent, Ashwini Shete, Anthony D. Kelleher, Manisha Ghate, Archana Kulkarni, Wen Shi Lee, Madhuri Thakar, Anne B. Kristensen

Publikováno v: JAIDS Journal of Acquired Immune Deficiency Syndromes. 75:345-353

There is growing interest in immune therapies to clear the latent HIV-1 after combination antiretroviral therapy (cART). There is limited information on the effect of cART on antibody-dependent cellular cytotoxicity (ADCC), and no studies have direct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635ad78fcf111db9710efb61d5e42bbf
https://doi.org/10.1097/qai.0000000000001380

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Modulation of the CCR5 Receptor/Ligand Axis by Seminal Plasma and the Utility of In Vitro versus In Vivo Models

Autor: Kevin J. Selva, Anne B. Kristensen, Anthony D. Kelleher, Stephen J. Kent, Andrew E. Grulich, Benjamin R Bavinton, Wen Shi Lee, Kathleen M. Wragg, Jennifer A Juno, Sharon R Lewin, Renée M. van der Sluis, Matthew S. Parsons

Publikováno v: Journal of Virology. 93

Sexual HIV-1 transmission occurs primarily in the presence of semen. Although data from macaque studies suggest that CCR5+ CD4+ T cells are initial targets for HIV-1 infection, the impact of semen on T cell CCR5 expression and ligand production remai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63a589a51840d0847b1c5eaadf8c044f
https://doi.org/10.1128/jvi.00242-19

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Modulation of the CCR5 Receptor/Ligand Axis by Seminal Plasma and the Utility of

Autor: Jennifer A, Juno, Kathleen M, Wragg, Anne B, Kristensen, Wen Shi, Lee, Kevin J, Selva, Renee M, van der Sluis, Anthony D, Kelleher, Benjamin R, Bavinton, Andrew E, Grulich, Sharon R, Lewin, Stephen J, Kent, Matthew S, Parsons

Publikováno v: Journal of virology. 93(11)

Sexual HIV-1 transmission occurs primarily in the presence of semen. Although data from macaque studies suggest that CCR5(+) CD4(+) T cells are initial targets for HIV-1 infection, the impact of semen on T cell CCR5 expression and ligand production r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::edaa01286df3256f44cad173e5b3d060
https://pubmed.ncbi.nlm.nih.gov/30867307

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