Zobrazeno 1 - 10
of 207
pro vyhledávání: '"Anne A Knowlton"'
Autor:
HyunTae V Hwang, Darlene Thuy Tran, Michelle Nicole Rebuffatti, Chin-Shang Li, Anne A Knowlton
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190374 (2018)
Previously, quercetin has been reported to be a senolytic, a drug that selectively removes senescent cells, in HUVECs. However, we found neither quercetin nor Q3G was effective as a senolytic for adult human endothelial cells.
Externí odkaz:
https://doaj.org/article/711a739bc8bb433dbde9f6dce9346a20
Publikováno v:
Am J Physiol Heart Circ Physiol
Exosomes are a subtype of extracellular vesicles. They range from 30 to 150 nm in diameter and originate from intraluminal vesicles. Exosomes were first identified as the mechanism for releasing unnecessary molecules from reticulocytes as they mature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffe63842b2dbb31dacff18224735bd93
https://doi.org/10.1152/ajpheart.00075.2020
https://doi.org/10.1152/ajpheart.00075.2020
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70719 (2013)
Inflammation is a key element in many cardiovascular diseases. Both estrogen loss, caused by menopause, and aging have inflammatory consequences. Epoxyeicosatrienoic acids (EETs) are anti-inflammatory molecules synthesized by various cytochrome P450
Externí odkaz:
https://doaj.org/article/8520dc3d24a64317af40b2fa3eda9ffe
Autor:
C. Enrique Guerrero-Beltrán, Iván Alfredo Mijares-Rojas, Indumathi Krishnan-Sivadoss, Guillermo Torre-Amione, Anne A Knowlton, Ramiro A. Villarreal-Leal
Publikováno v:
Medicinal research reviews. 41(1)
Cardiovascular diseases (CVDs) are the result of complex pathophysiological processes in the tissues comprising the heart and blood vessels. Inflammation is the main culprit for the development of cardiovascular dysfunction, and it may be traced to c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d2fd6230b21c151ca7c641c7412288
https://pubmed.ncbi.nlm.nih.gov/32808366
https://pubmed.ncbi.nlm.nih.gov/32808366
Publikováno v:
Autoimmune Diseases, Vol 2012 (2012)
The diabetes-atherosclerosis relationship remains to be fully defined. Repeated prolonged hyperglycemia, increased ROS production and endothelial dysfunction are important factors. One theory is that increased blood levels of heat shock protein (HSP)
Externí odkaz:
https://doaj.org/article/5d794f6de7b940dd8c2237192bbc5272
Autor:
Anne A Knowlton, Adam J. Poe
Publikováno v:
Essays in Biochemistry. 62:193-204
Exosomes have become an important player in intercellular signaling. These lipid microvesicles can stably transfer miRNA, protein, and other molecules between cells and circulate throughout the body. Exosomes are released by almost all cell types and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5c2bebd0ef96ba9df59bb8c4946b8c0
https://doi.org/10.1042/ebc20170081
https://doi.org/10.1042/ebc20170081
Autor:
Wenying Wang, Sassan Rafizadeh, Seojin Park, Hannah A. Ledford, Ebenezer N. Yamoah, Zheng Zhang, Anne A Knowlton, Xiao-Dong Zhang, Ling Lu, Victor C. Lau, Hyo Jeong Kim, Wilson Xu, Nipavan Chiamvimonvat
Publikováno v:
The Journal of Physiology. 595:2271-2284
The normal function of ion channels depends critically on the precise subcellular localization and the number of channel proteins on the cell surface membrane. Small-conductance, Ca2+-activated K+ channels (SK, KCa2) are expressed in human atrial myo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63d85eed5b5fe2c038b2fac0a7a2cfef
https://doi.org/10.1113/jp272942
https://doi.org/10.1113/jp272942
Autor:
Chin-Shang Li, Anne A Knowlton, Aldrin V. Gomes, Michelle Nicole Rebuffatti, Hyun Tae V. Hwang, Yun Lin, Lily Lee, Darlene Thuy Tran
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 316(2)
The heat shock response is an important cytoprotective mechanism for protein homeostasis and is an essential protective response to cellular stress and injury. Studies on changes in the heat shock response with aging have been mixed with regard to wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac05abd10bdafb8fa90db387c26e8390
https://pubmed.ncbi.nlm.nih.gov/30499713
https://pubmed.ncbi.nlm.nih.gov/30499713
Publikováno v:
Cell stress & chaperones, vol 20, iss 3
Extracellular (ex) HSP60 is increasingly recognized as an agent of cell injury. Previously, we reported that low endotoxin exHSP60 causes cardiac myocyte apoptosis. Our findings supported a role for Toll-like receptor (TLR) 4 in HSP60 mediated apopto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9f8ddadb666f46cafac3547792e09fc
https://doi.org/10.1007/s12192-015-0577-0
https://doi.org/10.1007/s12192-015-0577-0
Autor:
Padmini Sirish, Nipavan Chiamvimonvat, Ebenezer N. Yamoah, Zheng Zhang, Valeriy Timofeyev, Xiao-Dong Zhang, Ling Lu, Ryan L. Woltz, Ning Li, Anne A Knowlton
Publikováno v:
Journal of Biological Chemistry. 290:4663-4676
Cav1.3 L-type Ca(2+) channel is known to be highly expressed in neurons and neuroendocrine cells. However, we have previously demonstrated that the Cav1.3 channel is also expressed in atria and pacemaking cells in the heart. The significance of the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b687dc9999d093759573eed93870592
https://doi.org/10.1074/jbc.m114.586883
https://doi.org/10.1074/jbc.m114.586883