Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Anne Marie Jørgensen"'
Autor:
Anne Marie Jørgensen, Sid Topiol
Publikováno v:
Chemical Biology & Drug Design. 72:265-272
The potential mechanisms for driving a ligand to and through a transporter are examined for the leucine transporter using the recently published X-ray structure. Through analyses with computational methods, including investigation of electrostatic pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94d77c53e662c4f9b3bc1ed9b6427971
https://doi.org/10.1111/j.1747-0285.2008.00707.x
https://doi.org/10.1111/j.1747-0285.2008.00707.x
Autor:
Kristian Strømgaard, Jonas N. N. Eildal, Jacob Andersen, Anders S. Kristensen, Benny Bang-Andersen, Anne Marie Jørgensen, Morten Jørgensen
Publikováno v:
Journal of Medicinal Chemistry. 51:3045-3048
Citalopram and talopram are structurally closely related, but they have very distinct pharmacological profiles as selective inhibitors of the serotonin and norepinephrine transporters, respectively. A systematic structure-activity relationship study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56877ef5185c5b1d8744d7e64407c376
https://doi.org/10.1021/jm701602g
https://doi.org/10.1021/jm701602g
Publikováno v:
QSAR & Combinatorial Science. 25:221-234
A new similarity measure and structural clustering method has been developed in which each structure is fragmented into ring systems, linkers, and side chains, and where the similarity between structures forms a weighted sum of the similarities betwe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4dcf3a7fd7bea4f4bd408e22f664ce26
https://doi.org/10.1002/qsar.200510157
https://doi.org/10.1002/qsar.200510157
Publikováno v:
Journal of Chemical Information and Computer Sciences. 41:338-345
A novel method for assessing structural diversity is presented. Maximum common subgraph identity is used as the measure of similarity between two chemical structures. A conditional probability treatment of simmilarity distributions for libraries of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee0bd5f480a9f36bb051b01304fcac06
https://doi.org/10.1021/ci000111h
https://doi.org/10.1021/ci000111h
Autor:
Anne Marie Jørgensen, Henrik Gesmar, Ulla Badsberg, Lise-Lotte Jespersen, Jens Ulstrup, Jan M. Hammerstad, Jens J. Led
Publikováno v:
Biochemistry. 35:7021-7031
The three-dimensional solution structure of plastocyanin from Anabaena variabilis (A.v.PCu) has been determined by nuclear magnetic resonance spectroscopy. Sixty structures were calculated by distance geometry from 1141 distance restraints and 46 dih
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19814c113daceed6861f9da1cf344bd0
https://doi.org/10.1021/bi960621y
https://doi.org/10.1021/bi960621y
Autor:
Kristian Strømgaard, Flemming Jørgensen, Benny Bang-Andersen, Kasper B. Hansen, Anne Marie Jørgensen, Jacob Andersen, Lars Folke Olsen, Jan Egebjerg, Olivier Taboureau, Anders S. Kristensen
Publikováno v:
The Journal of biological chemistry. 285(3)
The serotonin transporter (SERT) regulates extracellular levels of the neurotransmitter serotonin (5-hydroxytryptamine) in the brain by facilitating uptake of released 5-hydroxytryptamine into neuronal cells. SERT is the target for widely used antide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f682d200909e1d4558c6eac197f237b0
https://pubmed.ncbi.nlm.nih.gov/19892699
https://pubmed.ncbi.nlm.nih.gov/19892699
Autor:
David Lloyd, Dilip K. Rai, Günther H.J. Peters, Andrew J. S. Knox, D. Clive Williams, Mary J. Meegan, Desmond Corrigan, Stephen Butler, John J. Keating, Suzanne M. Cloonan, Anne Marie Jørgensen
The discovery that some serotonin reuptake transporter (SERT) ligands have the potential to act as pro-apoptotic agents in the treatment of cancer adds greatly to their diverse pharmacological application. 4-Methylthioamphetamine (MTA) is a selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c5c9407a4cae422094d639e7b81bc09
https://hdl.handle.net/1959.8/159978
https://hdl.handle.net/1959.8/159978
Autor:
Klaus Peter Bogeso, Anne Marie Jørgensen, Günther H.J. Peters, Lena Tagmose, Anne Marie M. Jørgensen
Publikováno v:
ChemMedChem. 2(6)
We have performed molecular dynamics simulations of a homology model of the human serotonin transporter (hSERT) in a membrane environment and in complex with either the natural substrate 5-HT or the selective serotonin reuptake inhibitor escitalopram
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca668b0d5f1fdaf0e4a852551eaf499d
https://pubmed.ncbi.nlm.nih.gov/17436258
https://pubmed.ncbi.nlm.nih.gov/17436258
Autor:
Sid Topiol, Anne Marie Jørgensen, Lena Tagmose, Michael Sabio, Anne Marie M. Jørgensen, Klaus Peter Bogeso, Klaus Gundertofte, Günther H.J. Peters
Publikováno v:
ChemMedChem. 2(6)
The serotonin transporter (SERT) is one of the neurotransmitter transporters that plays a critical role in the regulation of endogenous amine concentrations and therefore is an important target for therapeutic agents affecting the central nervous sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a76871460386e64c515aeacd7f39bdd5
https://pubmed.ncbi.nlm.nih.gov/17405130
https://pubmed.ncbi.nlm.nih.gov/17405130
Publikováno v:
Physical chemistry chemical physics : PCCP. 7(19)
The temperature-dependent dynamics of the fully reduced and fully oxidized forms of Pseudomonas stutzeri cytochrome c4 have been studied by Mössbauer spectroscopy. Prior to the dynamic analysis, an efficient labelling strategy has been developed for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f98cd7925ca606ee98754f565a235c
https://pubmed.ncbi.nlm.nih.gov/16273148
https://pubmed.ncbi.nlm.nih.gov/16273148