Výsledky vyhledávání

Akademický článek

Environmentally Friendly Expeditious One-Pot Electrochemical Synthesis of Bis-Catechol-Thioether Metabolites of Ecstasy: in vitro Neurotoxic Effects in the Rat Hippocampus

Autor: Anne Felim, Anne Neudörffer, François P. Monnet and Martine Largeron

Publikováno v: International Journal of Electrochemical Science, Vol 3, Iss 3, Pp 266-281 (2008)

A straightforward one-pot electrochemical synthesis of bis-catechol-thioether metabolites of MDMA (ecstasy), 2,5-bis(glutathion-S-yl)-N-methyl-a-methyldopamine and 2,5-bis(N-acetylcystein-S-yl)-N-methyl-a-methyldopamine, in acceptable yields and high

Externí odkaz: https://doaj.org/article/e33c50d25cac4fb8839f0f8417d638cd

Zobrazit plný text záznamu

Synthesis and in Vitro Cytotoxicity Profile of the R-Enantiomer of 3,4-Dihydroxymethamphetamine (R-(−)-HHMA): Comparison with Related Catecholamines

Autor: Anne Felim, José-Enrique O'Connor, Martine Largeron, Manuel Blanco, Guadalupe Herrera, Anne Neudörffer

Publikováno v: Chemical Research in Toxicology
Chemical Research in Toxicology, American Chemical Society, 2010, 23 (1), pp.211-219. ⟨10.1021/tx9003374⟩

(+/-)-3,4-Methylenedioxymethamphetamine (MDMA, also known as "ecstasy") is a chiral drug that is essentially metabolized in humans through O-demethylenation into 3,4-dihydroxymethamphetamine (HHMA). There has recently been a resurgence of interest in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7893e149b9d5b1f22fc34077494ca7a
https://doi.org/10.1021/tx9003374

Zobrazit plný text záznamu

Further Studies on the Role of Metabolites in (±)-3,4-Methylenedioxymethamphetamine-Induced Serotonergic Neurotoxicity

Autor: George A. Ricaurte, Martine Largeron, Una D. McCann, Frank T. Peters, Jie Yuan, Hans H. Maurer, Anne Felim, Melanie Mueller, Anne Neudorffer

Publikováno v: Drug Metabolism and Disposition
Drug Metabolism and Disposition, American Society for Pharmacology and Experimental Therapeutics (ASPET), 2009, 37 (10), pp.2079-2086. ⟨10.1124/dmd.109.028340⟩

The mechanism by which the recreational drug (+/-)-3,4-methylenedioxymethamphetamine (MDMA) destroys brain serotonin (5-HT) axon terminals is not understood. Recent studies have implicated MDMA metabolites, but their precise role remains unclear. To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ba3d50690c570406e52c9b0f4aee08c
https://doi.org/10.1124/dmd.109.028340

Zobrazit plný text záznamu

Bacterial Plate Assays and Electrochemical Methods: An Efficient Tandem for Evaluating the Ability of Catechol−Thioether Metabolites of MDMA ('Ecstasy') to Induce Toxic Effects through Redox-Cycling

Autor: Anne Felim, Guadalupe Herrera, Manuel Blanco, Amparo Urios, Anne Neudorffer, Martine Largeron

Publikováno v: Chemical Research in Toxicology
Chemical Research in Toxicology, American Chemical Society, 2007, 20 (4), pp.685-693. ⟨10.1021/tx6003584⟩
CHEMICAL RESEARCH IN TOXICOLOGY
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
instname
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)

Several catechol-thioether metabolites of MDMA (ecstasy), three monoadducts, 5-(glutathion-S-yl)-N-methyl-alpha-methyldopamine (1), 5-(N-acetylcystein-S-yl)-N-methyl-alpha-methyldopamine (2), and 5-(cystein-S-yl)-N-methyl-alpha-methyldopamine (3), an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f1abe65655d7319422e649501f58d0b
https://doi.org/10.1021/tx6003584

Zobrazit plný text záznamu

Improved method for the iodine(III)-mediated preparation of aryl sulfonimidates

Autor: Max Malacria, Courtney R. Phillips, Dominique Leca, Louis Fensterbank, Anna L. Vagstad, Aurélie Toussaint, Anne Felim, and Emmanuel Lacôte

Publikováno v: Organic letters. 8(2)

[reaction: see text] One-pot hypervalent iodine-mediated oxidations of arylsulfinamides to arylsulfonimidates is reported. Contrary to the case of alkylsulfinamides, use of iodosobenzene was not satisfactory. The reaction worked best with diacetoxyio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9906aa5f76945e68234cbccbca6fe4e4
https://pubmed.ncbi.nlm.nih.gov/16408909

Zobrazit plný text záznamu

Histological Characteristics Of Hepatitis C-Associated B-Cell Non-Hodgkin Lymphomas. Results Of The French Lympho-C ANRS HC-13 Multicentric Study Of 133 Patients

Publikováno v: Blood. 122:3005-3005

Introduction HCV infection is associated with the development of B-cell non Hodgkin lymphomas (NHL), preferentially of marginal zone lymphomas (MZL) and diffuse large B-cell lymphomas (DLBCL) subtypes. Other subtypes of B-cell NHL are rare. HCV-relat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::620203e61f46fa3ecc0b29f013e3c4ec
https://doi.org/10.1182/blood.v122.21.3005.3005

Zobrazit plný text záznamu

Akademický článek

Synthesis and in Vitro Cytotoxicity Profile of the R-Enantiomer of 3,4-Dihydroxymethamphetamine (R-(â)-HHMA): Comparison with Related Catecholamines.

Autor: Anne Felim, Guadalupe Herrera, Anne NeudoÌrffer, Manuel Blanco, JoseÌ-Enrique OâConnor, Martine Largeron

Publikováno v: Chemical Research in Toxicology; Jan2010, Vol. 23 Issue 1, p211-219, 9p

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání